Category: 7355-55-7

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7355-55-7, name is 2-Amino-3,7-dihydropyrrolo[2,3-d]pyrimidin-4-one. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 2-Amino-3,7-dihydropyrrolo[2,3-d]pyrimidin-4-one

The G005 (10. 0g, 66. 6mmol) was added to lOOmLPOCl3, refluxed for 2h, the solvent spin After cooling to room temperature, the reaction was added to 120mL of ice water, and the solid was filtered, and the filtrate was washed with aqueous ammonia solution to pH = 2, and the ice bath and the precipitate As 2h after filtration, the solid was filtered and washed first with ice water 10mL, 30mL second ice was washed with ether, was drained after 8. 7g, 78% yield .

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Reference:
Patent; SHANGHAIJIAO TONG UNIVERSITY; EASTCHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY; SHEN, YUMEI; TANG, DAONIAN; SHAO, ZHIFENG; GONG, BING; LIU, YAZHI; WU, XINYAN; ZHAO, XIAODONG; LI, XIAOWEI; WEI, XIAOFEI; HU, YU; (21 pag.)CN103819523; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 7355-55-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7355-55-7, name is 2-Amino-3,7-dihydropyrrolo[2,3-d]pyrimidin-4-one. This compound has unique chemical properties. The synthetic route is as follows.

2-Amino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one (1.5 g, 0.01 mol) at room temperatureIodine (5.1 g, 0.02 mol) was dissolved in ethanol/water (2:1, 100 mL) and heated to reflux for 2 h.The precipitate was cooled and precipitated, and the precipitate was filtered, washed with 1N sodium thiosulfate solution (2×30 mL) and water (2×50 mL).After drying, 2-amino-6-iodo-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one was obtained.

According to the analysis of related databases, 7355-55-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Hebei Medical University; Wang Lei; Liu Yi; Zhang Congying; Gao Tianfeng; Zheng Qianqian; (37 pag.)CN110078735; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 7355-55-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7355-55-7, name is 2-Amino-3,7-dihydropyrrolo[2,3-d]pyrimidin-4-one. This compound has unique chemical properties. The synthetic route is as follows.

Step 1. Creation of the heterocycle (FIG. 3). To a solution of 2,4-diamino-6-hydroxypyrimidine (1, 25.2 g) in DMF (480 mL) and water (80 mL) was added sodium acetate (27.2 g). The resulting yellow solution was stirred for 1 h. To the solution was added chloroacetaldehyde (50% solution, 25.4 mL) and the mixture was stirred at rt for 2 days. The volatiles were removed in vacuo and the residue was mixed with methanol (70 mL) and stored at rt overnight. The resulting solid was filtered. The solid was mixed with methanol (150 mL) and heated at 60 C. for 10 min and cooled to rt overnight. The resulting solid was filtered and dried. The yield of 2 was 15 g to 19 g. (0032) A mixture of 7-deazaguanine (14.2 g) and dimethylaniline (6 mL) in POCl3 (200 mL) was refluxed for 3 h (bath temp. 130 C.). After cooling to rt, volatiles were removed by distillation (bath temp 60 C.). The residue was mixed with water (2300 mL) and neutralized with ammonium hydroxide until complete precipitation of solid (pH4). The resulting precipitate was filtered and further purified by column chromatography (silica, MC_MeOH=10:1) to give 3.6 g (21.4 mmol, 23%) of solid (FIG. 3).

According to the analysis of related databases, 7355-55-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Benner, Steven A; Kim, Hyo-Joong; (15 pag.)US10059735; (2018); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 7355-55-7 ,Some common heterocyclic compound, 7355-55-7, molecular formula is C6H6N4O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example IB4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine A suspension of Example 1A (25 g, 0.16 mol) in POCI3 (250 ml) was heated under reflux for 3 hours. After cooling to room temperature, excess of POCI3 was removed under vacuum. Ice water (250 ml) was added and the resulting solid was filtered off. The pH of the filtrate was adjusted to pH = 2 with aqueous ammonia. After leaving the precipitate in an ice bath, the mixture was filtered off, and was washed with cold water (25 ml) and cold ether (25 ml) consecutively. The solid was dried under vacuum to give the title compound. MS (ESI) (+) m/z 169.7 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7355-55-7, its application will become more common.

Reference:
Patent; ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; VAN CAMP, Jennifer; XU, Xiangdong; OSUMA, Augustine, Toby; GREGG, Robert; LONGENECKER, Kenton, L.; WO2012/45195; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 7355-55-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 7355-55-7 as follows.

A 50 cm3 round-bottomed flask containing a stirring bar was charged with 2- amino-3W-pyrrolo[2,3-d]pyrimidin-4(7A )-one (2.00 g, 13.33 mmol). The flask was fitted with a septum and placed under an Ar atmosphere. Freshly distilled pyridine (20.00 cm3) was added via syringe and the resulting suspension cooled on ice. The solution was allowed to equilibrate at this temperature (ca. 5 min) and then octanoyl chloride (6.80 cm3, 39.99 mmol) was added dropwise. The resulting suspension was heated at 85 C for 30 min. After cooling to room temperature 6.5% ethanolic ammonia (60 cm3) was added and the resulting suspension stirred at room temperature overnight. The precipitate of product was removed via vacuum filtration and washed with ethanol followed by diethyl ether to yield the desired product (2.56 g, 70%) pure as a yellow solid, m.p. > 300 C (decomposition). Procedure based on Akimoto et al. 1986 and Akimoto et al. 1988. deltaEta (400 MHz, DMSO-de): 0.86 (3H, t, J 5.1), 1.26 (8H, m), 1.58 (2H, app. quintet), 2.01 (1H, br s, NH), 2.43 (2H, t, J 5.1), 6.40 (1H, d, J 2.0), 7.01 (1H, d, J 2.0), 11.43 (1H, br s, NH), 11.67 (1H, br s, NH) HRMS (m/z ESI ) : Found : 275.1517 ([M-H]” C14H 19N4O2; Requires: 275.1508)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7355-55-7, its application will become more common.

Reference:
Patent; THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN; SOUTHERN, John, Michael; CONNON, Stephen, J.; (37 pag.)WO2016/50804; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia