Category: 739364-95-5

Electric Literature of 739364-95-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.739364-95-5, name is 2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid, molecular formula is C8H7N3O2, molecular weight is 177.16, as common compound, the synthetic route is as follows.

Compound of formula (1) (30 g) and N-hydroxysuccinimide (19.5 g)It was suspended in 200 mL of dichloromethane and a mixture of EDCI (36 g) in dichloromethane was added portionwise on an ice bath.The mixture was stirred at room temperature for 8 hours. Filtered to obtain 40 g of O-2,5-dicarbonylpyrrolyl-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxylate (I-1) as a white solid.Yield 86%.

The chemical industry reduces the impact on the environment during synthesis 739364-95-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Chenxin Pharmaceutical Co., Ltd.; Shanghai Pharmaceutical Industry Institute; Li Jianqi; Ni Feng; Zhang Yi; Zhang Shuxin; Zhang Jin; Wu Xiabing; Du Zhenxin; Lu Xiulian; (9 pag.)CN104974160; (2017); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 739364-95-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.739364-95-5, name is 2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid, molecular formula is C8H7N3O2, molecular weight is 177.16, as common compound, the synthetic route is as follows.

DPPA (0.5 mL, 2.31 mmol) and Et3N (1.2 mL, 8.3 mmol) were added at rt to a stirred solution of l-4b (300 mg, 1.69 mmol) in 1,4-dioxane (10 mL). The resulting reaction mixture was stirred at rt for 50 min, then l-3b (500 mg, 2.57 mmol) was added and the reaction mixture was stirred at 100 C for 2 h. When TLC indicated consumption of starting material the reaction mixture was cooled to rt, diluted in water (50 mL) and extracted with EtOAc (2 x 100 mL). The combined organic layers were washed with brine (50 mL), dried (Na2S04), filtered and concentrated. The crude material was purified by CombiFlash (silica gel) eluted with 8% MeOH in DCM. Fractions containing compound were combined and concentrated and the resulting solid was triturated in MeCN (2 x 5 mL) followed by trituration in EtOH (15 mL). and dried which gave the title compound (100 mg, 15%) as a solid. LCMS (ES+) m/z 369.20 [M+H]+.

The chemical industry reduces the impact on the environment during synthesis 739364-95-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; MEDIVIR AKTIEBOLAG; ERSMARK, Karolina; KARLSTROeM, Sofia; KLASSON, Bjoern; LUNDGREN, Stina; ROSENQUIST, Asa; SALVADOR ODEN, Lourdes; (155 pag.)WO2018/226150; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 739364-95-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 739364-95-5, name is 2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.

(Intermediate Example 111) 2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid (2-amino-2-methylpropyl)amide 2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid (0.18 g) was suspended in dichloromethane (5 ml), and N,N-dimethylformamide (1 drop) was added thereto. The mixture was cooled to 0C, and a solution of oxalyl chloride (10 mul) in dichloromethane (3 ml) was added dropwise thereto over 10 minutes, and the mixture was stirred as such for 1 hour at 0C. Thereafter, the mixture was stirred for 5 hours at room temperature to prepare the corresponding acid chloride. 2-Amino-2-methylpropylamine (0.11 g) was dissolved in dichloromethane, and triethylamine (0.33 ml) was added thereto and cooled to -78C. The prepared acid chloride solution was added dropwise thereto over 30 minutes and stirred as such for 30 minutes. The temperature of the mixture was increased to room temperature, and the mixture was stirred for 1 hour at room temperature. Water was added thereto, and the aqueous phase was acidified by 2 N hydrochloric acid. After washing with chloroform, the aqueous phase was alkalinized by 5 N sodium hydroxide solution and extracted with chloroform. The organic phase was washed with a saturated saline solution and dried over sodium sulfate anhydrous. The product was concentrated under reduced pressure to give the title compound (0.14 g, Y.: 56%) as yellow crystals. ESI/MS (m/z): 248 (M+H)+.

According to the analysis of related databases, 739364-95-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SANWA KAGAKU KENKYUSHO CO., LTD.; EP1595866; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 739364-95-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 739364-95-5, name is 2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid. A new synthetic method of this compound is introduced below.

(Intermediate Example 113) 2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid (4-amino-4-methylpentyl)amide 2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid (177 mg) was suspended in tetrahydrofuran (5 ml), and N,N-dimethylformamide (1 drop) was added thereto. Oxalyl chloride (100 mul) was added thereto with ice cooling, and the mixture was stirred for 30 minutes at room temperature. The mixture was cooled again on ice, and 4-methyl-1,4-pentane< >diamine (116 mul) and triethylamine (0.21 ml) were added thereto and stirred overnight at room temperature. By adding water and 2 N hydrochloric acid, the reaction mixture was acidified, followed by washing with chloroform. The aqueous phase was alkalinized by 5 N sodium hydroxide solution, extracted with chloroform, and the extract was dried over sodium sulfate anhydrous. The product was concentrated under reduced pressure to give the title compound (151 mg, Y.: 55%) as pale yellow crystals. 1H NMR; (CDCl3) delta (ppm): 1.1 (6H, s), 1.7 (4H, m), 2.5 (3H, s), 3.4 (2H, dd), 6.5 (1H, s), 8.4 (1H, brs), 8.7 (1H, d), 9.1 (1H, d). ESI/MS (m/z): 276 (M+H)+, 274 (M-H)-.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,739364-95-5, its application will become more common.

Reference:
Patent; SANWA KAGAKU KENKYUSHO CO., LTD.; EP1595866; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia