Category: 74356-36-8

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.74356-36-8, name is 2,4-Dimethyl-pyrimidine-5-carboxylic acid, molecular formula is C7H8N2O2, molecular weight is 152.1506, as common compound, the synthetic route is as follows.Quality Control of 2,4-Dimethyl-pyrimidine-5-carboxylic acid

110 mg (0.72 mmol) of 2,4-dimethyl-pyrimidine-5-carboxylic acid and 215 mg (0.57 mmol) of O-(benzotriazol-1-yl)N,N,N’,N’-tetramethyluronium-hexa-fluorophosphate are dissolved in 4 mL of N,N-dimethylformamide and 62 muL (0.57 mmol) of 4-methyl-morpholine are added. The mixture is stirred for 10 min and a solution of 170 mg (0.47 mmol) [(R)-1-piperidin-4-yl-2-(2,4,5-trifluoro-phenyl)-ethyl]-carbamic acid tert-butyl ester and 102 muL (0.57 mmol) of di-iso-propylethylamine in 4 mL of N,N-dimethylformamide is added. The reaction mixture is stirred for 2 h at room temperature, and diluted with ethyl acetate. The organic layer is washed with brine, saturated sodium bicarbonate solution and brine, dried with sodium sulfate, filtered and concentrated in vacuo to yield the title compound. LC/MS (I) (5-95%, 5 min): rt 3.89 min; m/z 437, 493 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,74356-36-8, 2,4-Dimethyl-pyrimidine-5-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; Santhera Pharmaceuticals (Schweiz) AG; BIOVITRUM AB; EP2019099; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 74356-36-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 74356-36-8, name is 2,4-Dimethyl-pyrimidine-5-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.

The compound of Reference Example 56 (253mg, 1.00mmol) and 2,4-dimethylpyrimidine-5-carboxylic acid (152mg, 1.00mmol) and 1-hydroxybenzotriazole (135mg, 1.00mmol) and 1-(3 dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (230 mg, 1.20 mmol) and triethylamine (418muL, 3.00mmol) and a mixture of N,N-dimethylformamide (2 mL) was stirred at room temperature for 16 hours. Thereafter, the reaction mixture was purified by directly preparative high-performance liquid column chromatography. Then the obtained product (157mg, 0.50mmol) in tetrahydrofuran (5.0 mL) lithium aluminum hydride (56.9mg, 1.50mmol) of was added at 10 C. After 16 hours with stirring at 10C , the water and 10% sodium hydroxide solution was added, the precipitate was removed by Celite filtration, and the filtrate was concentrated. The resulting concentrated residue was purified by preparative high-performance liquid column chromatography, to give the title compound (4%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 74356-36-8, 2,4-Dimethyl-pyrimidine-5-carboxylic acid.

Reference:
Patent; SUMITOMO DAINIPPON PHARMA COMPANY LIMITED; YOSHINAGA, HIDEFUMI; URUNO, YOSHIHARU; NAGATA, HIDETAKA; HASHIMOTO, MASAKAZU; KATO, TARO; (82 pag.)JP2016/108326; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 74356-36-8, name is 2,4-Dimethyl-pyrimidine-5-carboxylic acid. A new synthetic method of this compound is introduced below., COA of Formula: C7H8N2O2

Reference Example 78 2,4-dimethylpyrimidine 2,4-Dimethyl-5-pyrimidinecarboxylic acid was heated at 160C for 4 hrs. The reaction mixture was distilled under atmospheric pressure to give the title compound (17 g, yield 49%). boiling point 152-153C. 1H-NMR(CDCl3)delta: 2.50 (3H, s), 2.70 (3H, s), 6.98 (1H, d, J= 5.1Hz), 8.49 (1H, d, J= 5.1Hz).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 74356-36-8, 2,4-Dimethyl-pyrimidine-5-carboxylic acid.

Reference:
Patent; Takeda Chemical Industries, Ltd.; EP1364949; (2003); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 74356-36-8 , The common heterocyclic compound, 74356-36-8, name is 2,4-Dimethyl-pyrimidine-5-carboxylic acid, molecular formula is C7H8N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Reference Example L 78 2,4-dimethylpyrimidine 2,4-Dimethyl-5-pyrimidinecarboxylic acid was heated at 160C for 4 hrs. The reaction mixture was distilled under atmospheric pressure to give the title compound (17 g, yield 49%). b.p.: 152-153C. 1H-NMR(CDCl3)delta: 2.50 (3H, s), 2.70 (3H, s), 6.98 (1H, d, J= 5.1Hz), 8.49 (1H, d, J= 5.1Hz).

The synthetic route of 74356-36-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Takeda Chemical Industries, Ltd.; EP1402900; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia