Category: 74638-76-9

Cowden, William B. published the artcileCan nitrogen-15 NMR be used to determine the site of N-oxidation of pyrimidine-2,4-diamine?, Related Products of pyrimidines, the publication is Australian Journal of Chemistry (1981), 34(7), 1539-43, database is CAplus.

An examination of the products of N-oxidation of pyrimidine-2,4-diamine demonstrated that ¹⁵N spectroscopy is an unreliable technique for the determination of the site of N-oxidation The ¹⁵N shifts caused by N-oxidation were small and downfield and of no diagnostic value.

Australian Journal of Chemistry published new progress about 74638-76-9. 74638-76-9 belongs to pyrimidines, auxiliary class Pyrimidine, name is 2,4-Diaminopyrimidine-3-oxide, and the molecular formula is C4H6N4O, Related Products of pyrimidines.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Staedeli, Werner published the artcileNitrogen-15 spectroscopy. Part 5. Nitrogen-15 NMR studies of aminopyridines, aminopyrimidines and of some diazine N-oxides, Formula: C4H6N4O, the publication is Helvetica Chimica Acta (1980), 63(2), 504-22, database is CAplus.

¹⁵N NMR spectra were obtained in neutral and acidic media for mono- and diaminopyridines, and mono-, di-, and triaminopyrimidines. Ring N shifts are discussed in terms of β-, χ-, and δ-substituent effects of amino and alkyl groups. Protonation states in trifluoroacetic acid and FSO₃H solution and protonation effects on the ¹⁵N NMR spectra are determined A linear correlation is observed between amino substituent effects on the ring N-atom in aminopyridines and the corresponding ¹³C values in aminobenzenes, and, similarly, between ¹⁵N values in aminopyrimidines and ¹³C values in aminopyridines. One-bond ¹⁵N-H coupling constants for aminopyridines and aminopyrimidines are discussed in terms of conjugative interaction between NH₂ groups and the ring system.

Helvetica Chimica Acta published new progress about 74638-76-9. 74638-76-9 belongs to pyrimidines, auxiliary class Pyrimidine, name is 2,4-Diaminopyrimidine-3-oxide, and the molecular formula is C11H24O3, Formula: C4H6N4O.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Harisha, S. published the artcileClinical trials of water based compositions of active hair growth stimulants in the treatment of alopecia, Computed Properties of 74638-76-9, the publication is European Journal of Biomedical and Pharmaceutical Sciences (2014), 1(3), 284-305, database is CAplus.

Background: Androgenic Alopecia (AGA): Androgenic alopecia (also known as Androgenetic alopecia or Alopecia androgenetica), in male humans in particular this condition is also commonly known as male pattern baldness, hereditary alopecia and simply common baldness. Pathophysiol.: Androgenetic alopecia is a genetically determined disorder and is progressive through the gradual conversion of thick terminal hairs with fine, miniaturized hairs that are eventually lost. Patients with this disorder usually have a typical patterned distribution of hair loss. In Androgenetic alopecia, Studies have indicated a self-renewal of the hair follicle via keratinocyte stem cells located at the area of the bulge of the hair follicle. In addition, a series of studies using mice has indicated that interfollicular keratinocyte stem cells could generate de novo hair follicles in adult mouse skin. These regenerated hair follicles cycled through stages of telogen to anagen. However, these transitions between bulge and epidermal keratinocytes have not been seen yet in human studies. Another report has indicated that mice lacking in functional vitamin D receptors develop a functional first coat of hair, but lack the cyclic regeneration of hair follicles leading to the development alopecia. Whether these findings will lead to a new area of exploration into the cause of Androgenetic alopecia in humans is unknown at this time. Primary objective: To evaluate the Efficacy of topical application of study drug for the treatment of mild to moderate Androgenic Alopecia in Male Patients. Secondary objective: To evaluate the safety of topical application of study drug for the treatment of mild to moderate Androgenic Alopecia in Male Patients. Methods: Subjects were enrolled as per the inclusion and exclusion criteria. All the subjects were then randomized in to 5 different groups. Drug A= FD/SBF/MX-40* Drug B- FD/SBF/PY-39* Drug C- FD/WBF/MX-36* Drug D- FD/WBF/PY-37* Drug E- FD/WBF/KX-38* *Study samples provided by “Kumar Organic Products,Research Center Private Limited”.

European Journal of Biomedical and Pharmaceutical Sciences published new progress about 74638-76-9. 74638-76-9 belongs to pyrimidines, auxiliary class Pyrimidine, name is 2,4-Diaminopyrimidine-3-oxide, and the molecular formula is C4H6N4O, Computed Properties of 74638-76-9.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Siddiraju, S. published the artcileStability indicating RP-HPLC method development and validation for the simultaneous determination of aminexil and minoxidil in pharmaceutical dosage form, Application of 2,4-Diaminopyrimidine-3-oxide, the publication is Annales Pharmaceutiques Francaises (2015), 73(2), 114-122, database is CAplus and MEDLINE.

The objective of the present work is to develop stability indicating high-performance liquid chromatog. method for the simultaneous determination of aminexil and minoxidil in pharmaceutical dosage form. The chromatog. separation was achieved with BDS Hypersil C₁₈ column (250 mm × 4.6 mm × 5 μ) as stationary phase and phosphate buffer and acetonitrile (78:22) as mobile phase. The method was employed by using a flow rate of 1.1 mL/min kept at 30 °C. The detection wavelength was kept at 238 nm by using photo-diode array detector. The retention times of the aminexil and minoxidil were found to be 2.3 min and 3.9 min, resp. The method developed was validated in accordance with ICH guidelines with respect to the stability indicating capacity of the method including system suitability, accuracy, precision, linearity, range, limit of detection, limit of quantification and robustness. The linearity responses of aminexil and minoxidil were found to be in the concentration ranges of 18.75-112.5 μg/mL and 25-150 μg/mL, resp. The LOD and LOQ values for aminexil were found to be 0.31 and 0.92 μg/mL and minoxidil were found to be 0.03 and 0.10 μg/mL resp. The percentage recoveries for both the drugs were found in the range of 98-101%. This method is accurate, precise and sensitive; hence, it can be employed for routine quality control of aminexil and minoxidil in pharmaceutical industries and drug testing laboratories

Annales Pharmaceutiques Francaises published new progress about 74638-76-9. 74638-76-9 belongs to pyrimidines, auxiliary class Pyrimidine, name is 2,4-Diaminopyrimidine-3-oxide, and the molecular formula is C7H7IN2O, Application of 2,4-Diaminopyrimidine-3-oxide.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia