Category: 74840-38-3

Budesinsky, Zdenek published the artcileOn the synthesis of 4- and 5-pyrimidinyldiphenyl-(1-imidazolyl)methanes and their antifungal activity, Formula: C8H9BrN2O2S, the main research area is pyrimidinyldiphenylmethane imidazolyl; imidazolylpyrimidinyldiphenylmethane; fungicide imidazolylpyrimidinyldiphenylmethane; Grignard reaction pyrimidinecarboxylate.

The title compounds I (R1 = Me, SMe; R2 = Cl, Br; R3 = 1-imidazolyl) and II (R3 = 1-imidazolyl) were prepared by treating the corresponding pyrimidinyldiphenylmethanols I (R1 and R2 = as above, R3 = OH) (III) and II (R3 = OH) (IV) with thionylbisimidazole prepared in situ from SOCl2 and imidazole in MeCN solution III and IV were obtained by the Grignard reaction from the appropriately substituted Et pyrimidinecarboxylates and PhMgBr but Et 4-methyl-2-methylthio-5-pyrimidinecarboxylate gave with PhMgBr Et 1,6-dihydro-4-methyl-2-methylthio-6-phenyl-5-pyrimidinecarboxylate. 5-Bromo-2-methylthiopyrimidine failed to give Grignard’s reagent with Mg but reacted with EtMgBr yielding 5-bromo-3,4-dihydro-4-ethyl-2-methylthiopyrimidine. Three I and II were tested against Saccharomyces pasterianus, Trichophyton mentagrophytes, Candida albicans, and Aspergillus niger and showed weaker antifungal activities compared with clotrimazole.

Collection of Czechoslovak Chemical Communications published new progress about Fungicides. 74840-38-3 belongs to class pyrimidines, name is Ethyl 5-bromo-2-(methylthio)pyrimidine-4-carboxylate, and the molecular formula is C8H9BrN2O2S, Formula: C8H9BrN2O2S.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Riadi, Yassine published the artcileMicrowave Irradiation-Mediated Synthesis of New Substituted Pyridopyrimidines via the Suzuki-Miyaura Coupling Reaction and Biological Evaluation, Safety of Ethyl 5-bromo-2-(methylthio)pyrimidine-4-carboxylate, the main research area is pyridopyrimidine preparation antibacterial.

An eco-friendly, effective and easy route to synthesize substituted pyridopyrimidines I [Ar = Ph, 3-MeC6H4, 4-pyridyl, etc.] was reported starting from 4-methylsulfanylpyrido[3,2-d]pyrimidines that undergo a SuzukiMiyaura coupling reaction under microwave irradiation Initially, the chlorinated intermediate was prepared from the available chem. reagents. The prepared compounds were effectively synthesized by reacting the chlorinated intermediate with versatile boronic acids. The resulting products were tested for their antimicrobial efficiency against different microbes. In this way, three synthesized derivatives were found to be active against the studied bacterial strains. Unfortunately, the derivatives were found to be inactive against the studied fungus.

Polycyclic Aromatic Compounds published new progress about Antibacterial agents. 74840-38-3 belongs to class pyrimidines, name is Ethyl 5-bromo-2-(methylthio)pyrimidine-4-carboxylate, and the molecular formula is C8H9BrN2O2S, Safety of Ethyl 5-bromo-2-(methylthio)pyrimidine-4-carboxylate.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Regan, Collin F. published the artcileA facile synthesis of 5-halopyrimidine-4-carboxylic acid esters via a Minisci reaction, SDS of cas: 74840-38-3, the main research area is Minisci homolytic alkoxycarbonylation halopyrimidine; bromopyrimidinecarboxylate; pyrimidine halo Minisci homolytic alkoxycarbonylation.

This paper reports the synthesis of various 5-halopyrimidine-4-carboxylic acid esters via the Minisci homolytic alkoxycarbonylation of 5-halopyrimidines. The reaction was found to be highly regioselective, allowing the one-step synthesis of useful amounts (>10 g) of Et 5-bromopyrimidine-4-carboxylate where other methods proved difficult. Et 5-bromopyrimidine-4-carboxylate was used for the preparation of potent CK2 inhibitors including CX-5011. This work represents an interesting application of radical chem. for the preparation of pharmacol. active mols.

Synlett published new progress about Alkoxycarbonylation (Minisci homolytic). 74840-38-3 belongs to class pyrimidines, name is Ethyl 5-bromo-2-(methylthio)pyrimidine-4-carboxylate, and the molecular formula is C8H9BrN2O2S, SDS of cas: 74840-38-3.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 74840-38-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 74840-38-3 as follows.

A solution of 5-bromo-2-methylthio-pyrimidine-4-carboxylic acid ethyl ester (100 mg, 0.36 mmol ; prepared from 5-bromo-2-methylthio-pyrimidine-4-carboxylic acid according to Coll. Czech. Chem. Commun. 1980, 45(2), 539) in dichloromethane (5 ml) was stirred at 0 C. under argon atmosphere and a solution of 3-chloroperbenzoic acid (178 mg, 0.72 mmol) in dichloromethane (5 ml) was added slowly. After continuous stirring for 30 min and warming-up to r.t., stirring was continued for another 6 h. The reaction mixture was partitioned between dichloromethane and sodium bicarbonate (saturated aqueous solution) and extracted. The organic phase was washed with water, dried and the solvent was evaporated. The product was obtained after purification by silica gel chromatography using a heptane /ethyl acetate gradient as colorless waxy solid (86 mg, 77%). MS: M=309.0 (M+H)+

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,74840-38-3, its application will become more common.

Reference:
Patent; Bleicher, Konrad; Flohr, Alexander; Groebke Zbinden, Katrin; Gruber, Felix; Koerner, Matthias; Kuhn, Bernd; Peters, Jens-Uwe; Sarmiento, Rosa Maria Rodriguez; US2011/306589; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 74840-38-3, name is Ethyl 5-bromo-2-(methylthio)pyrimidine-4-carboxylate. A new synthetic method of this compound is introduced below., Recommanded Product: Ethyl 5-bromo-2-(methylthio)pyrimidine-4-carboxylate

Step 2: 5-Bromo-2-(2-methoxy-ethylamino)-pyrimidine-4-carboxylic acid ethyl ester2-Methoxyethylamine (0.278 ml, 3.2 mmol) was added at room temperature to a solution of 5- bromo-2-methanesulfonyl-pyrimidine-4-carboxylic acid ethyl ester (0.2 g, 0.65 mmol) in dichloromethane (5 ml). Stirring was continued at 45 C for 2 hours. The solvent was evaporated and the crude product was purified by silica gel chromatography using an ethyl acetate/heptane eluent to yield the title compound as colorless oil (0.175 g, 89 %).MS: M = 304.2 (M+H)+

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 74840-38-3, Ethyl 5-bromo-2-(methylthio)pyrimidine-4-carboxylate.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; BLEICHER, Konrad; FLOHR, Alexander; GROEBKE ZBINDEN, Katrin; KOERNER, Matthias; KUHN, Bernd; PETERS, Jens-Uwe; RODRIGUEZ SARMIENTO, Rosa Maria; VIEIRA, Eric; WO2011/89132; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia