Category: 75833-38-4

Electric Literature of 75833-38-4, Adding some certain compound to certain chemical reactions, such as: 75833-38-4, name is 2-Chloropyrimidine-4-carbonitrile,molecular formula is C5H2ClN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 75833-38-4.

General procedure: (2S)-N-(1-((3,3-difluorocyclobutyl)carbamoyl)-2,3-dihydro-1H-inden-1-yl)-N- (5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide (100 mg, 0.21 mmol), 2-chloroisonicotinonitrile( 29 mg, 0.21 mmol), Cs2CO3( 137 mg, 0.42 mmol), Pd2(dba)3(19 mg, 0.021 mmol) and Xant-Phos(24 mg, 0.042 mmol) was stirred under N2 at 90oC overnight. After filtration, the filtrate was concentrated in vacuo and the residue was purified by Pre-HPLC(base) to obtain two diastereoisomers as (S)-1-(4-cyanopyridin-2-yl)-N-((S)-1-((3,3-difluorocyclobutyl) carbamoyl)-2,3-dihydro-1H-inden-1-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide (1b, 10 mg, 9% yield) and (S)-1-(4-cyanopyridin-2-yl) -N-((R)-1-((3,3-difluorocyclobutyl) carbamoyl)-2,3-dihydro-1H-inden-1-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2- carboxamide as white solid(1b?, 12 mg10% yield).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 75833-38-4, 2-Chloropyrimidine-4-carbonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zheng, Qiangang; Tang, Shuai; Fu, Xianlei; Chen, Ziqi; Ye, Yan; Lan, Xiaojing; Jiang, Lei; Huang, Ying; Ding, Jian; Geng, Meiyu; Huang, Min; Wan, Huixin; Bioorganic and Medicinal Chemistry Letters; vol. 27; 23; (2017); p. 5262 – 5266;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 75833-38-4, name is 2-Chloropyrimidine-4-carbonitrile. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C5H2ClN3

Reference Example 107 tert-Butyl [methyl(6-cyano-2-pyrimidinyl)amino]acetate 2-Chloro-6-cyanopyrimidine (1.45 g, 10.4 mmol), sarcosine tert-butyl ester hydrochloric acid (1.89 g, 10.4 mmol) and triethylamine (1.60 ml, 11.4 mmol) were added to DMF (30 ml), and the mixture was stirred at room temperature for 18 hrs.. The reaction mixture was combined with ethyl acetate and water.. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate.. The solvent was evaporated to give the titled compound (1.99 g, 77 %) as pale yellow crystals.1H-NMR (CDCl3) delta: 1.47 (9H, s), 3.24 (3H, d, J = 5.5 Hz), 4.22 (2H, d, J = 8.7 Hz), 6.80 (1H, d, J = 4.7 Hz), 8.43-8.51 (1H, m). IR(-KBr): 2237, 1736, 1574, 1537, 1410, 1365, 1226, 1153, 1033, 815 cm-1.

With the rapid development of chemical substances, we look forward to future research findings about 75833-38-4.

Reference:
Patent; Takeda Chemical Industries, Ltd.; EP1424336; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 75833-38-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 75833-38-4 as follows.

To 2-chloropyrimidine-4-carbonitrile [2.5 g, prepared by the procedure of Daves et. al. (J. Het. Chem. 1964, 1, 130-132)] in EtOH (250 ml) under N2 was added Boc2O (7.3 g). After the mixture was briefly placed under high vacuum and flushed with N2, 10% Pd/C (219 mg) was added. H2 was bubbled though the mixture (using balloon pressure with a needle outlet) as it stirred 4.2 h at RT. After filtration through Celite, addition of 1.0 g additional Boc2O, and concentration, the residue was purified by silica gel chromatography (5:1 – 4:1 hexanes/EtOAc) to obtain N-Boc-(2-chloropyrimidin-4-yl)-methylamine.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,75833-38-4, its application will become more common.

Reference:
Patent; Amgen Inc.; US2003/225106; (2003); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 75833-38-4, Adding some certain compound to certain chemical reactions, such as: 75833-38-4, name is 2-Chloropyrimidine-4-carbonitrile,molecular formula is C5H2ClN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 75833-38-4.

EXAMPLE 15 To a stirred solution of 3.0 g (21.5 mmole) of 2-chloro-4-cyanopyrimidine in 50 ml of ethanol was added 3.75 g (43 mmole) of morpholine. After stirring for 1.5 hours at about 20 C., the precipitate was separated by filtration, and washed with ethanol to provide yellow solid 4-cyano-2-(4-morpholino)pyrimidine. The structural assignment was confirmed by infrared and nuclear magnetic resonance spectral analyses.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 75833-38-4, 2-Chloropyrimidine-4-carbonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Riker Laboratories, Inc.; US4478835; (1984); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 75833-38-4, 2-Chloropyrimidine-4-carbonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 75833-38-4, blongs to pyrimidines compound. name: 2-Chloropyrimidine-4-carbonitrile

2-Chloropyrimidine-4-carbonitrile (22.42 mg, 0.161 mmol), Na2C03 (134 muEpsilon, 0.268 mmol), (S)-3-(4-(6-amino-5-(4,4,5,5-tetramethyl- l,3,2-dioxaborolan-2- yl)pyridin-3-yl)phenyl)-5,5-dimethyl-4-phenyloxazolidin-2-one (65mg, 0.134 mmol), and dichloro(l,l-bis(diphenylphosphinoferrocene))palladium(II) (10.94 mg, 0.013 mmol) were combined in dioxane (268 mu) and stirred at 100C in a microwave oven for 1 hour. LC-MS indicated good conversion to desired product. After cooling to room temperature, the reaction mixture was absorbed onto a plug of silica gel and purified by chromatography through a Redi-Sep pre-packed silica gel column (12 g), eluting with a gradient of 0 % to 10 % MeOH in DCM, to provide (S)-2-(2-amino-5-(4- (5,5-dimethyl-2-oxo-4-phenyloxazolidin-3-yl)phenyl)pyridin-3-yl)pyrimidine-4- carbonitrile as yellow solid. NMR (500 MHz, DMSO-d6) delta 10.56 (s, 1H), 8.83 (d, J = 4.70 Hz, 1H), 8.59 (d, J= 2.67 Hz, 1H), 8.13 (d, J= 8.44 Hz, 1H), 8.06 (dd, J= 2.14, 6.30 Hz, 1H), 7.66 (d, J= 8.66 Hz, 2H), 7.58 (d, J= 8.87 Hz, 2H), 7.49 (d, J= 4.49 Hz, 1H), 7.35 – 7.42 (m, 2H), 7.23 – 7.35 (m, 3H), 5.49 (s, 1H), 1.66 (s, 3H), 0.92 (s, 3H). m/z (ESI) 463.8 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,75833-38-4, its application will become more common.

Reference:
Patent; AMGEN INC.; BREGMAN, Howard; BUCHANAN, John, L.; CHAKKA, Nagasree; DIMAURO, Erin; GUNAYDIN, Hakan; GUZMAN PEREZ, Angel; HUA, Zihao; HUANG, Hongbing; HUANG, Xin; MARTIN, Matthew, W.; PATEL, Vinod; WO2013/134079; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 75833-38-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 75833-38-4, name is 2-Chloropyrimidine-4-carbonitrile. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 2-chloropyrirnidine-4-carbonitrile (900 mg, 6.45 mmol) in dioxane (8 mL)/water (2 mL) was added K2C03 (2.20 g, 16.12 mmol), Pd(dppf)Cl2 (1.0 g, 1.29 mmol) and 4,4,5, 5-tetramethyl-2-vinyl-l,3,2-dioxaborolane (1.5 g, 9.67 mmol). The resulting mixture was stirred at 90 C overnight. After cooling to RT, the mixture was diluted with water (10 mL) and extracted with EtOAc (30 mL x 3). The combined organic layers were washed with brine, dried over Na2SC>4, filtered, and concentrated in vacuo. The residue was purified by silica gel chromatography column (9% EtOAc in petroleum ether) to give the title compound as a solid. LRMS m/z (Mu+Eta) 132.1 found, 132.1 required.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 75833-38-4, 2-Chloropyrimidine-4-carbonitrile.

Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott, D.; LIVERTON, Nigel; LUO, Yunfu; (85 pag.)WO2016/100156; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 75833-38-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.75833-38-4, name is 2-Chloropyrimidine-4-carbonitrile, molecular formula is C5H2ClN3, molecular weight is 139.54, as common compound, the synthetic route is as follows.

A solution of 2-chloropyrimidine-4-carbonitrile (163 mg, 1.17 mmol), 2-amino-1-(piperidin-1-yl)ethanone hydrochloride (240 mg, 1.34 mmol) and DIPEA (0.510 mL, 2.92 mmol) in acetonitrile (2 mL) was stirred at 100 C for 16 hr. The reaction mixture was partitioned between ethyl acetate (20 mL) and water (20 mL), and the organic layer was washed with water (20 mL). The aqueous was back-extracted with ethyl acetate (2 x 10 mL) and the combined organic layers were dried through a hydrophobic frit and evaporated to dryness. The crude product was purified by silica chromatography (0-50 % (3:1 ethyl acetate:ethanol + 1 %triethylamine)/cyclohexane). Appropriate fractions were evaporated to dryness to afford 2-((2-oxo-2-(piperidin-1-yl)ethyl)amino)pyrimidine-4-carbonitrile (240 mg, 0.978 mmol, 84 % yield) as a yellow solid. LCMS (High pH, ES+): tR = 0.80 min, [M+H+ 246.2. 1H NMR (400 MHz, CDCl3) delta 1.52 – 1.76 (m, 6 H), 3.42 (t, J = 5.1 Hz, 2 H), 3.54 – 3.67 (m, 2 H), 4.16 (d, J = 4.0 Hz, 2 H), 6.67 (br. s., 1 H), 6.85 (d, J = 4.5 Hz, 1 H), 8.47 (d, J = 4.8 Hz, 1 H). 13C NMR (101 MHz, CDCl3) delta 24.4, 25.4, 26.2, 43.0, 43.2, 45.5, 113.5, 116.1, 141.3, 160.1, 161.6, 165.9. numax (neat): 3347, 2935, 2854, 1643, 1579, 1547, 1529, 1481, 1440, 1403, 1339, 1255, 1233, 1200, 1134, 1077, 1008, 855, 805, 734 cm-1. HRMS: (C12H16N5O) [M+H]+ requires 246.1349, found [M+H]+ 246.1342.

The chemical industry reduces the impact on the environment during synthesis 75833-38-4, I believe this compound will play a more active role in future production and life.

Reference:
Article; Law, Robert P.; Ukuser, Sabri; Tape, Daniel T.; Talbot, Eric P. A.; Synthesis; vol. 49; 16; (2017); p. 3775 – 3793;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia