Category: 76044-36-5

Synthetic Route of 76044-36-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 76044-36-5, name is 5-Chloro-[1,2,4]triazolo[1,5-c]pyrimidine, molecular formula is C5H3ClN4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 5-choro-[I,2,4]triazoo[l,5-c]pyrimidine (120 mg, 776 mhio) in DMA (3.88 mL) was added (35,4;S)-3-methyl~2-oxa~8~azaspiro[4.5]decan-4-amine his hydrochloride (277 mg, 1.16 mmol) and DIPEA (675 m]_, 3.88 mmol). The reaction mixture was stirred in a capped vial at 90 C for 1 h. The resulting mixture was concentrated under reduced pressure and the crude residue was carried onto the next step without any further purification. LCMS (ESI): m/z: [M + H] calculated for C ui fuNA). 289.2; found 289.3.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 76044-36-5, 5-Chloro-[1,2,4]triazolo[1,5-c]pyrimidine.

Reference:
Patent; REVOLUTION MEDICINES, INC.; KOLTUN, Elena S.; AAY, Naing N.; BUCKL, Andreas; MELLEM, Kevin T.; BLANK, Brian R.; PITZEN, Jennifer; WANG, Gang; JOGALEKAR, Ashutosh S.; WON, Walter S.; TZITZILONIS, Christos; LI, Jie Jack; GILL, Adrian Liam; CREGG, James Joseph; (207 pag.)WO2019/118909; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 76044-36-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.76044-36-5, name is 5-Chloro-[1,2,4]triazolo[1,5-c]pyrimidine, molecular formula is C5H3ClN4, molecular weight is 154.56, as common compound, the synthetic route is as follows.

A solution of 155 mg (1 mmol) of 5-chloro[l,2,4]triazolo[l,5-c]pyrimidine [D. J. Brownand K. Shinozuka, Aust. J. Chem., 33., 1147 (1980)] in 6 mL of dry ethanol was added gradually to avigorously stirred solution of 198 mg (204 mg, 4 mmol) of hydrazine monohydrate in 2 mL of dryethanol. A white precipitate separated during the addition. After 1.5 h, the solid was collected on afilter. It was suspended in 2 mL of concentrated ammonium hydroxide and agitated for a few minutes.The solid was then collected on a filter and washed with some additional concentrated ammoniumhydroxide, then with some ethanol, and finally with a large volume of diethyl ether. After drying, thetitle compound was obtained as a white solid, mp 245-246 C (decomposition). LC-MS 151 (M+l).

Statistics shows that 76044-36-5 is playing an increasingly important role. we look forward to future research findings about 5-Chloro-[1,2,4]triazolo[1,5-c]pyrimidine.

Reference:
Patent; MERCK & CO., INC.; WO2006/23750; (2006); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia