Category: 769-42-6

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 769-42-6, name is 1,3-Dimethylbarbituric acid. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 769-42-6

General procedure: A mixture of isatin (1 mmol), malononitrile (1 mmol) and dimedone (1 mmol) was stirred at room temperature in the presence of SnO2 nanoparticles and 2 mL of EtOH. The reaction progress was monitored by TLC (n-hexane/ethyl acetate, 2:1 ratio). After that, the resulted mixture (containing the solid product and nano catalyst) was dissolvedin acetone and filtered for separation of the catalyst. Finally, the product 5a was obtained after evaporation of acetone and for further purification recrystallized from EtOH.

With the rapid development of chemical substances, we look forward to future research findings about 769-42-6.

Reference:
Article; Moradi, Leila; Ataei, Zeynab; Zahraei, Zohreh; Journal of the Iranian Chemical Society; vol. 16; 6; (2019); p. 1273 – 1281;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 769-42-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 769-42-6, name is 1,3-Dimethylbarbituric acid, molecular formula is C6H8N2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A mixture of 1.1 mmol aromatic aldehyde, 0.144 g 2 (1 mmol), 0.156 g 3 (1 mmol), and 0.01 g ZnO NPs (10 mol%) in a round bottom flask was heated in an oil bath at 110 C for 20-35 min. During the reflux the reaction was monitored by TLC (eluent: n-hexane: ethyl acetate, 1:1). After completion of the reaction the mixture was cooled to room temperature, then the reaction mixture was dissolved in dichloromethane and stirred for 5 min. The suspended solution was filtered and then heterogeneous nanocatalyst was recovered. Then solvent was evaporated and the solid was recrystallized from methanol to afford the pure product 4.

According to the analysis of related databases, 769-42-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Mohaqeq, Mahboubeh; Safaei-Ghomi, Javad; Monatshefte fur Chemie; vol. 146; 9; (2015); p. 1581 – 1586;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 769-42-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 769-42-6 as follows.

General procedure: To a mixture of aldehyde (1.1 mmol), beta-naphthol(1.0 mmol), and 1,3-dimethylbarbutyric acid (1.0 mmol),3 mol% of ZrOCl2/nano-TiO2 were added as the catalyst,and the mixture was stirred for an appropriate time at 100C in an oil bath. After completion of the reaction, indicatedby TLC, the reaction mixture was dissolved in the appropriatevolume of hot ethanol, stirred for 5 min, filtered,and the heterogeneous catalyst recovered. Solution withproduct was concentrated and recrystallized from ethanolto get pure compound.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,769-42-6, its application will become more common.

Reference:
Article; Mohaqeq, Mahboubeh; Safaei-Ghomi, Javad; Shahbazi-Alavi, Hossein; Acta Chimica Slovenica; vol. 62; 4; (2015); p. 967 – 972;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 769-42-6, 1,3-Dimethylbarbituric acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines

General procedure: To a solution of L-proline-melamine complex (3 mol%) in DMSO (2 mL) was added dimedone 0.025 mg (0.178 mmol), malononitrile (1 equiv) and benzaldehyde / isatin (1 equiv) and stirred at room temperature for 1-20 min. After completion of the reaction (monitored by TLC), ethyl acetate was added stirring and continued for another 5 min. The precipitate formed was filtered. Evaporation of solvent gave the crude product which was recrystallized using ethanol to give the pure compound.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,769-42-6, 1,3-Dimethylbarbituric acid, and friends who are interested can also refer to it.

Reference:
Article; Nagaraju, Sakkani; Paplal, Banoth; Sathish, Kota; Giri, Santanab; Kashinath, Dhurke; Tetrahedron Letters; vol. 58; 44; (2017); p. 4200 – 4204;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 769-42-6, 1,3-Dimethylbarbituric acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines

General procedure: A mixture of 1,3-dimethylbarbituric acid 1 (2 mmol) with an aromatic aldehyde 2a-2i (1 mmol), ammonium acetate 3 (1.2 mmol) and Fe 3 O 4 nanoparticles (0.075 g) in EtOH-H 2 O (2.5 : 2.5 mL) was refluxed for 20-35 min. The reaction was monitored by TLC. Upon completion of the process, the catalyst was separated using an external magnet. The reaction mixture was cooled down to room temperature. The crude product was filtered off and crystallized from ethanol to give compounds 5a-5f and 4g-4i in high yields. The isolated catalyst was washed with hot ethanol, dried at 60C under vacuum for 1 h and reused in the following similar experiments. The synthesized earlier products 4g-4i were characterized by IR and 1 H NMR spectra and their melting points were close to those of authentic samples [29, 30].

At the same time, in my other blogs, there are other synthetic methods of this type of compound,769-42-6, 1,3-Dimethylbarbituric acid, and friends who are interested can also refer to it.

Reference:
Article; Fattahi; Davoodnia; Pordel; Russian Journal of General Chemistry; vol. 87; 4; (2017); p. 863 – 867;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 769-42-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.769-42-6, name is 1,3-Dimethylbarbituric acid, molecular formula is C6H8N2O3, molecular weight is 156.1393, as common compound, the synthetic route is as follows.

To a solution of 1,3-dimethylbarbituric acid (3.90 grams, 25.0 mmol) in 100 mL hot H2O was added a solution of benzaldehyde (2.65 grams, 25.0 mmol) in EtOH (20 mL). The resultant mixture was stirred vigorously while heating at reflux. After 5 hours, the mixture was allowed to cool to room temperature, and the precipitate was collected via filtration, washing with additional water. After drying overnight, this provided 5-benzylidene-l,3-dimethylpyrimidine-2,4,6-trione (5.90 grams, 97% yield) as a pale yellow solid.

Statistics shows that 769-42-6 is playing an increasingly important role. we look forward to future research findings about 1,3-Dimethylbarbituric acid.

Reference:
Patent; 3M INNOVATIVE PROPERTIES COMPANY; MOSER, William H.; TOWNSEND, Erik M.; THOMPSON, Zachary J.; CARUSO DAILEY, Mary M.; KROPP, Michael A.; (46 pag.)WO2019/152187; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 769-42-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 769-42-6, name is 1,3-Dimethylbarbituric acid, molecular formula is C6H8N2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

1,3-dimethylbarbituric acid (compound SM1) (7 kg, 44.9mmo1) dissolved in 120 kg phosphorus oxychloride (POCl3). To it, slowly drop water (2.2 kg, 22mo1). After dropping. slowly heating to reflux 6 hours; HPLC monitoring, after the reaction, the temperature, the reaction liquid slowly poured into a large amount of ice water (100L), then 50L dichloromethane extraction two times, the combined organic phase, saturated salt water washing (20L), anhydrous sodium sulfate drying, filtering, concentrating the organic phase, dried under vacuum to get yellow solid 7.2 kg, SM2 is the compound, yield 92.3%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 769-42-6, 1,3-Dimethylbarbituric acid.

Reference:
Patent; Shanghai Baiteyin Pharmaceutical Technology Co., Ltd.; Zhu Yiping; Sun Lianhua; (7 pag.)CN103755705; (2017); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia