Category: 7752-72-9

Synthetic Route of 7752-72-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7752-72-9, name is 5-Chloro-6-methylpyrimidin-4(3H)-one, molecular formula is C5H5ClN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: POCl3 (100 mL) was added dropwise to a solution of M-2 (0.36 mol)in toluene (150 mL), the mixture was refluxed for 3-5 h. The reactionmixture was concentrated under reduced pressure to remove tolueneand extra POCl3, and then poured into ice water. The water phase wasextracted with ethyl acetate (3 × 50 mL), the emerged organic phasewas successively washed with saturated sodium bicarbonate, dried overanhydrous magnesium sulfate, filtered and then concentrated underreduced pressure. The residue was purified through silica column togive M-3 as yellow liquid.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 7752-72-9, 5-Chloro-6-methylpyrimidin-4(3H)-one.

Reference:
Article; Guan, Aiying; Wang, Mingan; Chen, Wei; Yang, Fan; Yang, Jinlong; Zhao, Yu; Li, Zhinian; Liu, Changling; Journal of Fluorine Chemistry; vol. 201; (2017); p. 49 – 54;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 7752-72-9 ,Some common heterocyclic compound, 7752-72-9, molecular formula is C5H5ClN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

50 ml of POCl3 was added dropwise to a solution of 14.5 g (0.1 mol) of 4-hydroxyl-5-chloro-6-methylpyrimidine in 50 mL of toluene, the mixture was refluxed for 5-7 h after addition. After the reaction was over by Thin-Layer Chromatography monitoring, the reaction mixture was concentrated under reduced pressure to remove toluene and extra POCl3, and then poured into ice water. The water phase was extracted with ethyl acetate (3*50 mL), the organic phases were merged, dried over anhydrous magnesium sulfate, filtered and then concentrated under reduced pressure. The residue was purified through silica column (ethyl acetate/petroleum ether=1:5, as an eluent) to give14.43 g as yellow liquid with yield of 88.5%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7752-72-9, its application will become more common.

Reference:
Patent; Shenyang Sinochem Agrochemicals R&D Co., Ltd.; Liu, Changling; Guan, Aiying; Wang, Junfeng; Sun, Xufeng; Li, Zhinian; Zhang, Jinbo; Ban, Lanfeng; Ma, Sen; Lan, Jie; Xia, Xiaoli; Yang, Jinlong; (65 pag.)US2018/141961; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7752-72-9, name is 5-Chloro-6-methylpyrimidin-4(3H)-one. This compound has unique chemical properties. The synthetic route is as follows. name: 5-Chloro-6-methylpyrimidin-4(3H)-one

14.5g (0.1mol) 4- hydroxy-5-chloro-6-methylpyrimidine dissolved in 50ml of toluene, was added dropwise with stirring to the reaction flask 50ml phosphorus oxychloride, after dropwise addition the reaction heated at reflux for 5-7 hours, TLC monitored after completion of the reaction. Toluene was evaporated under reduced pressure and excess phosphorus oxychloride, with stirring the reaction was poured into ice water, the aqueous phase was extracted with ethyl acetate (3 × 50ml), the combined organic phase was dried over anhydrous magnesium sulfate, filtered, and dissolved. The residue was purified by column chromatography (eluent, ethyl acetate and petroleum ether (boiling range 60-90 deg. C), the volume ratio of 1: 4) was isolated as a yellow liquid 14.43g, yield 88.5%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 7752-72-9, 5-Chloro-6-methylpyrimidin-4(3H)-one.

Reference:
Patent; Sinochem Agrochemicals R & D Co., Ltd.; Guan, Aiying; Yang, Fan; Wang, Junfeng; Chen, Wei; Fan, Xiaoxi; Wang, Xiuli; Chen, Xuanming; Li, Keke; Li, Zhinian; Liu, Zhangling; (73 pag.)CN105732585; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 7752-72-9, 5-Chloro-6-methylpyrimidin-4(3H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 5-Chloro-6-methylpyrimidin-4(3H)-one, blongs to pyrimidines compound. Application In Synthesis of 5-Chloro-6-methylpyrimidin-4(3H)-one

2) The Preparation of Intermediate 4,5-dichloro-6-methylpyrimidine 50 ml of POCl3 was added dropwise to a solution of 14.5 g (0.1 mol) of 4-hydroxyl-5-chloro-6-methylpyrimidine in 50 mL of toluene, the mixture was refluxed for 5-7 h after addition. After the reaction was over by Thin-Layer Chromatography monitoring, the reaction mixture was concentrated under reduced pressure to remove toluene and extra POCl3, and then poured into ice water. The water phase was extracted with ethyl acetate (3*50 ml), the organic phases were emerged, dried over anhydrous magnesium sulfate, filtered and then concentrated under reduced pressure. The residue was purified through silica column to give 14.43 g as yellow liquid with yield of 88.5%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,7752-72-9, 5-Chloro-6-methylpyrimidin-4(3H)-one, and friends who are interested can also refer to it.

Reference:
Patent; SINOCHEM CORPORATION; Liu, Changling; Guan, Aiying; Lan, Jie; Wang, Lizeng; Wang, Bin; Zhu, Minna; Sun, Qin; Ren, Weijing; Feng, Cong; Ren, Lanhui; Chai, Baoshan; Li, Zhinian; US2015/225378; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7752-72-9, name is 5-Chloro-6-methylpyrimidin-4(3H)-one, the common compound, a new synthetic route is introduced below. Product Details of 7752-72-9

2) Preparation of 4,5-dichloro-6-methylpyrimidineThe 14.5g (0.1mol) 4-hydroxy-5-chloro-6-methylpyrimidine dissolved in 50ml of toluene, was added dropwise with stirring to the reaction flask 50ml of phosphorus oxychloride dropwise at reflux temperature the reaction completion 5-7 hours after, TLC monitored the reaction is complete. The toluene was evaporated under reduced pressure and an excess of phosphorus oxychloride, while stirring the reaction was poured into ice water, the aqueous phase was extracted with (3 ¡Á 50ml) and extracted with ethyl acetate, the combined organic phase was dried over anhydrous magnesium sulfate, filtered, desolvation . The residue was purified by column chromatography (eluent, ethyl acetate and petroleum ether (boiling range 60-90 ), the volume ratio of 1: 4) was isolated as a yellow liquid 14.43g, yield 88.5%.

The synthetic route of 7752-72-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shenyang SinochemAgrochemicals R&D Co., Ltd.; Liu, Zhangling; Xu, Ying; Wang, Junfeng; Sun, Xufeng; Ban, Lanfeng; Xie, Yong; Li, Zhinian; Sun, Geng; (59 pag.)CN105348298; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia