Category: 785777-98-2

On December 23, 2021, Arasappan, Ashok; Bell, Ian M.; Bungard, Christopher James; Burgey, Christopher S.; Cox, Jason M.; Kelly, Michael J., III; Layton, Mark E.; Liu, Hong; Liu, Jian; Perkins, James J.; Shah, Akshay A.; Vanheyst, Michael David; Wu, Zhe published a patent.Safety of 2,5-Dichloro-4-(trifluoromethyl)pyrimidine The title of the patent was 2-Oxoimidazolidine-4-carboxamides as NaV1.8 inhibitors and their preparation. And the patent contained the following:

Compounds of formula I, and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders. Compounds of formula I wherein one of A and B is (un)substituted aryl and (un)substituted heteroaryl, and the other one of A and B is (un)substituted aryl, (un)substituted heteroaryl, (un)substituted C1-6 alkyl-aryl, (un)substituted C3-8 cycloalkyl-aryl, etc.; R1, R2, R3 and R4 are independently H, (un)substituted C1-6 alkyl, (un)substituted C3-6 alkenyl, (un)substituted C3-6 alkynyl, (un)substituted C3-10 cycloalkyl, etc.; R5 is H and (un)substituted C1-6 alkyl; R6 is H, (un)substituted C1-6 alkyl, (un)substituted C3-6 cycloalkyl and (un)substituted C2-6 cycloheteroalkyl; R7 is H, (un)substituted C1-6 alkyl, (un)substituted C2-6 alkenyl and (un)substituted C2-6 alkynyl; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their NaV1.8 inhibitory activity (data given). The experimental process involved the reaction of 2,5-Dichloro-4-(trifluoromethyl)pyrimidine(cas: 785777-98-2).Safety of 2,5-Dichloro-4-(trifluoromethyl)pyrimidine

The Article related to oxoimidazolidinecarboxamide preparation sodium channel inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Safety of 2,5-Dichloro-4-(trifluoromethyl)pyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On August 5, 2021, Saulnier, Mark George; Chen, Jesse Jingyang; Karra, Srinivasa; Sprott, Kevin Tyler; Wiles, Jason Allan; Ray, Soumya published a patent.SDS of cas: 785777-98-2 The title of the patent was ASGPR-binding compounds for the degradation of extracellular proteins. And the patent contained the following:

Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described. The experimental process involved the reaction of 2,5-Dichloro-4-(trifluoromethyl)pyrimidine(cas: 785777-98-2).SDS of cas: 785777-98-2

The Article related to asgpr ligand preparation extracellular protein degradation disease therapy, Pharmacology: Effects Of Inflammation Inhibitors and Immune Agents and other aspects.SDS of cas: 785777-98-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On December 23, 2021, Arasappan, Ashok; Bell, Ian M.; Bungard, Christopher James; Burgey, Christopher S.; Cox, Jason M.; Kelly, Michael J., III; Layton, Mark E.; Liu, Hong; Liu, Jian; Perkins, James J.; Shah, Akshay A.; Vanheyst, Michael David; Wu, Zhe published a patent.Safety of 2,5-Dichloro-4-(trifluoromethyl)pyrimidine The title of the patent was 2-Oxoimidazolidine-4-carboxamides as NaV1.8 inhibitors and their preparation. And the patent contained the following:

Compounds of formula I, and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders. Compounds of formula I wherein one of A and B is (un)substituted aryl and (un)substituted heteroaryl, and the other one of A and B is (un)substituted aryl, (un)substituted heteroaryl, (un)substituted C1-6 alkyl-aryl, (un)substituted C3-8 cycloalkyl-aryl, etc.; R1, R2, R3 and R4 are independently H, (un)substituted C1-6 alkyl, (un)substituted C3-6 alkenyl, (un)substituted C3-6 alkynyl, (un)substituted C3-10 cycloalkyl, etc.; R5 is H and (un)substituted C1-6 alkyl; R6 is H, (un)substituted C1-6 alkyl, (un)substituted C3-6 cycloalkyl and (un)substituted C2-6 cycloheteroalkyl; R7 is H, (un)substituted C1-6 alkyl, (un)substituted C2-6 alkenyl and (un)substituted C2-6 alkynyl; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their NaV1.8 inhibitory activity (data given). The experimental process involved the reaction of 2,5-Dichloro-4-(trifluoromethyl)pyrimidine(cas: 785777-98-2).Safety of 2,5-Dichloro-4-(trifluoromethyl)pyrimidine

The Article related to oxoimidazolidinecarboxamide preparation sodium channel inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Safety of 2,5-Dichloro-4-(trifluoromethyl)pyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On August 5, 2021, Saulnier, Mark George; Chen, Jesse Jingyang; Karra, Srinivasa; Sprott, Kevin Tyler; Wiles, Jason Allan; Ray, Soumya published a patent.SDS of cas: 785777-98-2 The title of the patent was ASGPR-binding compounds for the degradation of extracellular proteins. And the patent contained the following:

Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described. The experimental process involved the reaction of 2,5-Dichloro-4-(trifluoromethyl)pyrimidine(cas: 785777-98-2).SDS of cas: 785777-98-2

The Article related to asgpr ligand preparation extracellular protein degradation disease therapy, Pharmacology: Effects Of Inflammation Inhibitors and Immune Agents and other aspects.SDS of cas: 785777-98-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On January 2, 2020, Kanouni, Toufike; Arnold, Lee D.; Kaldor, Stephen W.; Murphy, Eric A.; Tyhonas, John published a patent.Recommanded Product: 785777-98-2 The title of the patent was Inhibitors of cyclin-dependent kinases. And the patent contained the following:

Provided herein are inhibitors of cyclin-dependent kinases (CDKs), pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases. The experimental process involved the reaction of 2,5-Dichloro-4-(trifluoromethyl)pyrimidine(cas: 785777-98-2).Recommanded Product: 785777-98-2

The Article related to cyclin dependent kinase cdk12 inhibitor preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Recommanded Product: 785777-98-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On July 1, 2015, Shore, Daniel G. M.; Wasik, Kimberly A.; Lyssikatos, Joseph P.; Estrada, Anthony A. published an article.COA of Formula: C5HCl2F3N2 The title of the article was Minisci alkylations of electron-deficient pyrimidines with alkyl carboxylic acids. And the article contained the following:

A practical method for the Minisci reaction of electron-deficient pyrimidines with carboxylic acids is described. The one-step protocol allows for the alkylation of halo- and trifluoromethyl pyrimidines with a variety of readily available alkyl and (hetero)cycloalkyl carboxylic acids. These conditions permitted the facile synthesis of substituted pyrimidines, which are poised for further elaboration through divergent means. The experimental process involved the reaction of 2,5-Dichloro-4-(trifluoromethyl)pyrimidine(cas: 785777-98-2).COA of Formula: C5HCl2F3N2

The Article related to minisci alkylation electron deficient pyrimidine alkyl carboxylic acid, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.COA of Formula: C5HCl2F3N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On October 11, 2004, Ondi, Levente; Lefebvre, Olivier; Schlosser, Manfred published an article.HPLC of Formula: 785777-98-2 The title of the article was Brominated 4-(trifluoromethyl)pyrimidines: A convenient access to versatile intermediates. [Erratum to document cited in CA141:395506]. And the article contained the following:

Throughout the paper, the incorrect reagent names “phosphorus tribromide” and “phosphorus trichloride” should be replaced by the correct names “phosphoric tribromide” (POBr3) and “phosphoric trichloride” (POCL3). The experimental process involved the reaction of 2,5-Dichloro-4-(trifluoromethyl)pyrimidine(cas: 785777-98-2).HPLC of Formula: 785777-98-2

The Article related to erratum brominated trifluoromethylpyrimidine preparation, pyrimidine trifluoromethyl bromo preparation erratum, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.HPLC of Formula: 785777-98-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On August 27, 2004, Ondi, Levente; Lefebvre, Olivier; Schlosser, Manfred published an article.SDS of cas: 785777-98-2 The title of the article was Brominated 4-(trifluoromethyl)pyrimidines: A convenient access to versatile intermediates. And the article contained the following:

An expedient route to all three monobrominated and all three dibrominated isomers of 4-(trifluoromethyl)pyrimidine, and to several other halogenated pyrimidines, is described. Key steps are the electrophilic introduction of the halogen in the 5-position of 2- or 4-pyrimidinones, the bromodeoxygenation of pyrimidinones or thiopyrimidinones using phosphorus tribromide, and the partial debromination of dibromo-4-(trifluoromethyl)pyrimidines. The experimental process involved the reaction of 2,5-Dichloro-4-(trifluoromethyl)pyrimidine(cas: 785777-98-2).SDS of cas: 785777-98-2

The Article related to brominated trifluoromethylpyrimidine preparation, pyrimidine trifluoromethyl bromo preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.SDS of cas: 785777-98-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On March 28, 2019, Wailes, Jeffrey Steven; Briggs, Emma; Carter, Neil Brian; Morris, Melloney; Tate, Joseph Andrew published a patent.Related Products of 785777-98-2 The title of the patent was Preparation of pyrimidinyl carbamate or urea derivatives as herbicides. And the patent contained the following:

The present invention relates to herbicidally active pyridyl-(or pyrimidyl-) pyrimidine derivatives I [X1 = N or CR1; R1 = H, halo, CN, etc.; R2 = halo, CN, NO2, etc.; R3 = C(O)X2R12; X2 = O or NR10; R4 = H, alkyl, alkoxy, etc.; when X2 = O, R12 = alkyl, alkoxyalkyl, haloalkyl, etc.; when X2 = NR10, R12 = H, alkyl, alkoxy, etc.; R10 = (independently) H, alkyl, cycloalkyl; n = 0-1] or salts or N-oxides thereof, as well as to processes and intermediates used for the preparation of such derivatives E.g., a 2-step synthesis of II, starting from 2-chloro-4-methylpyrimidine-5-carboxylic acid, was described. Exemplified compounds I were evaluated for their pre-emergence and post-emergence herbicidal activities (data given). The invention further extends to herbicidal compositions comprising such derivatives I, as well as to the use of I and compositions in controlling undesirable plant growth: in particular the use in controlling weeds, in crops of useful plants. The experimental process involved the reaction of 2,5-Dichloro-4-(trifluoromethyl)pyrimidine(cas: 785777-98-2).Related Products of 785777-98-2

The Article related to pyrimidinyl pyridylpyrimidinyl pyrimidylpyrimidinyl carbamate urea preparation herbicide, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Related Products of 785777-98-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On August 4, 2010, Marhold, Albrecht; Ebenbeck, Wolfgang; Knauer, Stephan published a patent.Computed Properties of 785777-98-2 The title of the patent was Preparation of polyfluoro-N-heteroaromatics. And the patent contained the following:

A process for the preparation of title compounds I [X = N-heteroaromatic with provisos; A = fluoroalkyl, fluoroalkoxy, fluoroalkylthio; R1 = (R1′)n; R1′ = alkyl, aryl, arylalkyl; n = 0-1; Y = (Y’)m; Y’ = Cl, Br, F; m = 1-3] was disclosed. For example, HF/Autoclave(150°C) mediated fluorination of 2,4-dichloro-5-trichloropyrimidine afforded claimed polyfluoro-N-heteroaromatic II in 68% yield. The experimental process involved the reaction of 2,5-Dichloro-4-(trifluoromethyl)pyrimidine(cas: 785777-98-2).Computed Properties of 785777-98-2

The Article related to polyfluoropyrazine preparation fluorination, polyfluoropyrimidine preparation fluorination, polyfluoropyridazine preparation fluorination, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Computed Properties of 785777-98-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia