Category: 81560-03-4

Application of 81560-03-4, Adding some certain compound to certain chemical reactions, such as: 81560-03-4, name is 5-Bromo-2-(methylthio)pyrimidin-4(3H)-one,molecular formula is C5H5BrN2OS, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 81560-03-4.

Example 11 Synthetic route

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 81560-03-4, 5-Bromo-2-(methylthio)pyrimidin-4(3H)-one, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK SHARP & DOHME CORP.; ZHOU, Changyou; ZOU, Wuxin; HUA, Yuxia; DANG, Qun; WO2011/133444; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 81560-03-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 81560-03-4, name is 5-Bromo-2-(methylthio)pyrimidin-4(3H)-one. This compound has unique chemical properties. The synthetic route is as follows.

Step 3, Preparation of 5-bromo-4-chloro-2-methylthiopyrimidine: take 5-bromo-2-methylthio-4-pyrimidinone 110g, dissolve in 400g pyridine, and raise the temperature of the system to 80.100 g of phosphorus oxychloride was added dropwise. After the addition was completed, the reaction was continued for 5 h. After the reaction was completed,Cool to room temperature, ice bath, adjust the pH to 8-9 with saturated sodium bicarbonate, extract with 500 ml of ethyl acetate, dry over anhydrous magnesium sulfate, filter,The filtrate was decompressed to recover the solvent, and the residue was recrystallized from petroleum ether:ethyl acetate=1:3 to obtain 98 g of light yellow solid powder in a yield of 83%.

According to the analysis of related databases, 81560-03-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shanghai Weiju Industrial Co., Ltd.; Liu Hui; (6 pag.)CN107488175; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 81560-03-4, Adding some certain compound to certain chemical reactions, such as: 81560-03-4, name is 5-Bromo-2-(methylthio)pyrimidin-4(3H)-one,molecular formula is C5H5BrN2OS, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 81560-03-4.

To a mixture containing 0.70 g (5.5 mmol) of dimethyl sulfate and 0.25 g (4.5 mmol) of potassium hydroxide in 10ml of tetrahydrofuran was added 0.5 g (2.25 mmol) of 5- Bromo-2-(methylthio)pyrirnidin-4(3H)-one in portions over 15 min. After complete addition, the mixture was stirred overnight then diluted with ethyl acetate and washed with water. The organic phase was dried over magnesium sulfate. Filtration, removal of solvent and purification of the residue via Biotage chromatography eluting with 20 % ethyl acetate/ dichloromethane gave 0.5 g (94 %) of product. ¹H NMR (CDC13) No.: 2.58 (s , 3H) , 3.58 (s, 3H) , 8.06 (s, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 81560-03-4, 5-Bromo-2-(methylthio)pyrimidin-4(3H)-one, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2005/99688; (2005); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia