Category: 815610-16-3

Adding a certain compound to certain chemical reactions, such as: 815610-16-3, 2-Amino-4-iodopyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 815610-16-3, blongs to pyrimidines compound. Recommanded Product: 815610-16-3

A flask containing a solution of 55-iodide (4.09g, 18.5mmol) in NMP (75ml) was purged with argon for 5min. Zinc cyanide (2.28g, 19.4mmol) and tetrakis(triphenylphosphine)palladium (0) (1.71g, 1.48mmol) were added and the mixture was stirred at 80C for 2h. The mixture was cooled to room temperature, EtOAc (200ml) and 30% aqueous NH4OH (200ml) was added, and stirring was continued for 1h. The layers were separated, the aqueous layer was extracted with EtOAc (4×200ml), and the combined organic layers were concentrated under reduced pressure. Et2O (30ml) was added and the precipitate was collected by filtration and washed with Et2O to deliver 2-aminopyrimidine-4-carbonitrile (1.66g, 13.8mmol, 75% yield) as a white solid. 1H NMR (400MHz, DMSO-d6) delta ppm 8.51 (d, J=4.7Hz, 1H), 7.31 (br. s, 2H), 7.08 (d, J=4.7Hz, 1H). MS (ESI, pos. ion) m/z: 121.1 (M+1).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,815610-16-3, its application will become more common.

Reference:
Article; Reichelt, Andreas; Bailis, Julie M.; Bartberger, Michael D.; Yao, Guomin; Shu, Hong; Kaller, Matthew R.; Allen, John G.; Weidner, Margaret F.; Keegan, Kathleen S.; Dao, Jennifer H.; European Journal of Medicinal Chemistry; vol. 80; (2014); p. 364 – 382;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 815610-16-3, 2-Amino-4-iodopyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 815610-16-3, blongs to pyrimidines compound. Product Details of 815610-16-3

To a solution of 4-iodopyrimidin-2-amine (400 mg, 1.8 MMOL) in THF (10 mL) was added Pd (PPh3) 2CI2 (63 mg, 0.09 MMOL), Cul (34 mg, 0.18 mmol), TMS-acetylene (510 muL, 3.6 MMOL), and TEA (750 SLL, 5.4 MMOL). The mixture was heated to 50C for 1 hr. The solvent was removed in vacuo. THF (8 mL) and MeOH (1 mL) was added to the crude material followed by KF (313 mg, 5.4 MMOL). The material was concentrated and used crude in subsequent reactions

At the same time, in my other blogs, there are other synthetic methods of this type of compound,815610-16-3, 2-Amino-4-iodopyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2005/16914; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia