823-89-2 | Pyrimidines

9/17 News The origin of a common compound about 823-89-2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,823-89-2, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 823-89-2, 5-Bromo-2-hydrazinopyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 823-89-2, blongs to pyrimidines compound. Recommanded Product: 823-89-2

Step 2. Synthesis of (E)-2-(2-benzylidenehydrazinyl)-5-bromopyrimidine. To a boiling solution of 5-bromo-2-hydrazinylpyrimidine (1.0 g, 5.3 mmol) in ethanol (40 mL) was added benzaldehyde (0.6 g, 1.1 eq). The mixture was stirred for 2-3 h. Solvent was removed under reduced pressure and the residue was treated with aq. NaHCO3 solution and extracted with CHCl3. Organic layer was separated, washed with water and dried to give desired hydrazone (700 mg). M.p.=189-190 C. 1H NMR 400 MHz (DMSO-d6) 811.50 (s, 1H), 8.60 (s, 1H), 8.20 (s, 1H), 7.66 (m, 2H), 7.39 (m, 3H). LCMS m/e 278 (M+H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,823-89-2, its application will become more common.

Reference:
Patent; ArQule, Inc.; US2011/160226; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

7 Sep 2021 News Application of 823-89-2

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 823-89-2, 5-Bromo-2-hydrazinopyrimidine.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 823-89-2, name is 5-Bromo-2-hydrazinopyrimidine. A new synthetic method of this compound is introduced below., SDS of cas: 823-89-2

5-Bromo-2-hydrazino-pyrimidine (1.02 g, 5.43 mmol) and 6-quinoline acetic acid (1.02 g, 5.43 mmol) were dissolved in dichloromethane (78 mL) and stirred at room temperature for 12 hours. The desired product was insoluble in dichloromethane and precipitated upon formation. The precipitate was filtered off and taken onto subsequent reactions as crude product, quinolin-6-yl-acetic acid N’-(5-bromo-pyrimidin-2-yl)-hydrazide (theoretical yield 1.94 g).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 823-89-2, 5-Bromo-2-hydrazinopyrimidine.

Reference:
Patent; SGX PHARMACEUTICALS, INC.; WO2008/144767; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Introduction of a new synthetic route about 5-Bromo-2-hydrazinopyrimidine

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,823-89-2, its application will become more common.

Synthetic Route of 823-89-2 ,Some common heterocyclic compound, 823-89-2, molecular formula is C4H5BrN4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: Substituted chalcones (3) (0.001 mol), 5-bromo-2-hydrazinylpyrimidine (2) (0.001 mol) and 5 drops of glacial acetic acid was ground together in a mortar using a pestle for uniform mixing. This was taken in a 50 mL beaker and subjected to microwave irradiation (90 W). The completion of the reaction was confirmed by TLC. The product obtained was poured to crushed ice, filtered, dried and recrystallized from suitable solvent mixture to give pyrazolines 4a-l.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,823-89-2, its application will become more common.

Reference:
Article; Adhikari, Adithya; Kalluraya, Balakrishna; Sujith, Kizhakke Veedu; Gouthamchandra, Kuluvar; Jairam, Ravikumar; Mahmood, Riaz; Sankolli, Ravish; European Journal of Medicinal Chemistry; vol. 55; (2012); p. 467 – 474;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

A new synthetic route of 823-89-2

The chemical industry reduces the impact on the environment during synthesis 823-89-2, I believe this compound will play a more active role in future production and life.

Related Products of 823-89-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.823-89-2, name is 5-Bromo-2-hydrazinopyrimidine, molecular formula is C4H5BrN4, molecular weight is 189.01, as common compound, the synthetic route is as follows.

The chemical industry reduces the impact on the environment during synthesis 823-89-2, I believe this compound will play a more active role in future production and life.

Brief introduction of 823-89-2

Statistics shows that 823-89-2 is playing an increasingly important role. we look forward to future research findings about 5-Bromo-2-hydrazinopyrimidine.

Electric Literature of 823-89-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.823-89-2, name is 5-Bromo-2-hydrazinopyrimidine, molecular formula is C4H5BrN4, molecular weight is 189.01, as common compound, the synthetic route is as follows.

A mixture of A-68 (500.00 mg, 2.65 mmol) in CH(OEt)3 (882.54 _1_, 5.30 mmol) was stirred at 120 C for 16 hours The mixture was diluted with EtOH (5 mL) and the solid formed was collected by filtration, washed with EtOH (5 mL x 3) and dried in oven to afford A-71 (400.00 mg, 1.99 mmol) as a solid. H NMR (400MHz, CDC13) _ = 8.81 (s, 1H), 8.68 (d, 1H), 8.62 (d, 1H). LCMS R, = 0.15 min using Method B, MS ESI calcd. for C5H4BrN4 [M+H+2]+ 201.0, found 200.9

Statistics shows that 823-89-2 is playing an increasingly important role. we look forward to future research findings about 5-Bromo-2-hydrazinopyrimidine.

Reference:
Patent; PRAXIS PRECISION MEDICINES, INC.; REDDY, Kiran; MARTINEZ BOTELLA, Gabriel; GRIFFIN, Andrew, Mark; MARRON, Brian, Edward; (364 pag.)WO2018/98499; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Extended knowledge of 823-89-2

At the same time, in my other blogs, there are other synthetic methods of this type of compound,823-89-2, 5-Bromo-2-hydrazinopyrimidine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 823-89-2, 5-Bromo-2-hydrazinopyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C4H5BrN4, blongs to pyrimidines compound. HPLC of Formula: C4H5BrN4

At the same time, in my other blogs, there are other synthetic methods of this type of compound,823-89-2, 5-Bromo-2-hydrazinopyrimidine, and friends who are interested can also refer to it.