Category: 830346-47-9

Application of 830346-47-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 830346-47-9 as follows.

Bromine (3.2 g) was added to a solution of 1-(2-fluoro-6-(trifluoromethyl)benzyl)- 6-methylpyrimidine-2,4(1H,3H)-dione (6.0 g, 0.019 mmol) in acetic acid and stirred for 3 h at ambient temperature. Residue obtained was filtered and filtrate was diluted with ethyl acetate. The ethyl acetate layer was washed with sat. NaHCO3 solution. Organic layer was separated, washed with Na2S2O3 solution and then concentrated to give titled solid material (6.6 g, 87 percent).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,830346-47-9, its application will become more common.

Reference:
Patent; LUPIN LIMITED; SULAKE, Rohidas, Shivaji; SHINDE, Sagar, Raosaheb; SIYAN, Rajinder, Singh; BHISE, Nandu, Baban; SINGH, Girij, Pal; (22 pag.)WO2018/198086; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 830346-47-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 830346-47-9 as follows.

Bromine (16.5 mL, 0.32 mmol) was added to 1- [2-FLUORO-6- (trifluoromethyl) benzyl]-6-methylpyrimidine-2, 4 (1H, 3H)-dione lc (48.5 g, 0.16 mol) in 145 mL of acetic acid. The resulting mixture became clear then formed precipitate within an hour. After 2 hours stirring, the yellow solid was filtered and washed with cold EtOAc to an almost white solid. The filtrate was washed with sat. NAHC03 and dried over NA2S04. Evaporation gave a yellow solid which was washed with ETOAC to give a light yellow solid. The two solids were combined to give 59.4 g of LD (0.156 mol) total NMR (CDC13) 8 2.4 (s, 3H), 5.48 (s, 2H), 7.25-7. 58 (M, 3H), 8.61 (s, 1H) ; MS (CI) m/z 380.9 (MH).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,830346-47-9, its application will become more common.

Reference:
Patent; NEUROCRINE BIOSCIENCES, INC.; WO2005/7165; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.830346-47-9, name is 1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione, molecular formula is C13H10F4N2O2, molecular weight is 302.22, as common compound, the synthetic route is as follows.Safety of 1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione

To a 50 mL round botom flask was added AcOH (20 mL), compound IX (2 g) and N-Iodosuccinimide (1.5 g). The reaction mixture was heated to 50 °C for lh. After completion of the reaction, LLO (10 mL) was added to the reaction mixture. The resulting suspension was filtered. The cake was washed with MeOH (4 mL). The solid was slurried with MeOH (20 mL) to give the product as a white solid (2.3 g, 82percent yield, 96.1percent purity). NMR (400 MHz, DMSO-d6) d 11.75 (s, 1H), 77.67-7.61 (m, 1H), 7.59-7.50 (m, 2H), 5.39 (s, 1H), 2.56 (s, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,830346-47-9, 1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione, and friends who are interested can also refer to it.

Reference:
Patent; WANG, Peng; LI, Pixu; GU, Xiangyong; YANG, Hailong; WANG, Zhong; JIANG, Qianghua; LIU, Yuanhua; XIA, Hui; (24 pag.)WO2019/112968; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 830346-47-9, name is 1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione. This compound has unique chemical properties. The synthetic route is as follows. category: pyrimidines

To a 250 mL three-neck round bottom flask was charged l-(2-fluoro-6- trifluoromethyl-benzyl)-6-methyl-lH-pyrimidine-2,4-dione Ia (25.0 g) and methanol (250 mL). Iodine monochloride (30.9 g) was charged over 2.5 min. The mixture was heated at 50 0C for 3 hours. After cooling to ambient temperature, the mixture was filtered. The cake was re-slurried in methanol (250 mL) and heated to 50 C for 3 hours. After cooling to ambient temperature, the mixture was filtered and the filter cake was washed with methanol (50 mL). The off-white solid was dried in a vacuum oven at 50 C to provide l-(2-fluoro-6-trifluoromethyl-benzyl)-5-iodo-6-methyl-lH-pyrimidine-2,4- dione Ib (32.5 g, 90% yield). LCMS (ESI) m/z 429.3 (MH+). The material may be re- slurried in MeOH as needed.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 830346-47-9, 1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione.

Reference:
Patent; NEUROCRINE BIOSCIENCES, INC.; WO2009/62087; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 830346-47-9 ,Some common heterocyclic compound, 830346-47-9, molecular formula is C13H10F4N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Bromine (16.5 mL, 0.32 mmol) was added to 1- [2-FLUORO-6- (trifluoromethyl) benzyl] -6-methylpyrimidine-2, 4 (1H, 3H)-DIONE lc (48. 5 g, 0.16 mol) in 145 mL of acetic acid. The resulting mixture became clear then formed precipitate within an hour. After 2 hours stirring, the yellow solid was filtered and washed with cold EtOAc to an almost white solid. The filtrate was washed with sat. NAHC03 and dried over NA2S04. Evaporation gave a yellow solid which was washed with ETOAC to give a light yellow solid. The two solids were combined to give 59.4 g of ld (0.156 mol) total NMR (CDC13) 8 2.422 (s, 3H), 5.478 (s, 2H), 7.246-7. 582 (m, 3H), 8.611 (s, 1H) ; MS (CI) M/Z 380.9 (MH+). 5-Bromo-1-[2, 6-difluorobenzyl]-6-methylpyrimidine-2, 4 (1H, 3H)-dione ld. 1 was made using the same procedure.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 830346-47-9, 1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NEUROCRINE BIOSCIENCES, INC.; WO2005/7164; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 830346-47-9, name is 1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione, molecular formula is C13H10F4N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione

Step 1D: Preparation of 5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6- methylpyrimidine-2,4 (1H,3H)-dione 1-1; Bromine (16.5 mL, 0.32 mmol) was added to 1-[2-fluoro-6- (trifluoromethyl)benzyl]-6-methylpyrimidine-2,4(IH,3H)-dione 1c (48.5 g, 0.16 mol) in 145 mL of acetic acid. The resulting mixture became clear then formed precipitate within an hour. After 2 hours stirring, the yellow solid was filtered and washed with cold EtOAc to an almost white solid. The filtrate was washed with sat. NaHC03 and dried over Na2S04. Evaporation gave a yellow solid which was washed with EtOAC to give a light yellow solid. The two solids were combined to give 59.4 g of 1-1 (0.156 mol) total. 1H NMR (CDC13) No. 2.4 (3H, s), 5.48 (2H, s), 7.25 – 7.58 (3H, m), 8.61 (1H, s) ; MS (CI) m/z 380.9 (MH+).

With the rapid development of chemical substances, we look forward to future research findings about 830346-47-9.

Reference:
Patent; NEUROCRINE BIOSCIENCES, INC.; WO2005/113516; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia