Category: 83255-86-1

Related Products of 83255-86-1 ,Some common heterocyclic compound, 83255-86-1, molecular formula is C5H4BrN5, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Add N, N-dimethylacetamide (50mL) to the reaction flask,Add 4-phenoxybenzoic acid (II) (4.81g, 0.022mol) under nitrogen protection,3-bromo-4-amino-1H-pyrazolo [3,4, d] pyrimidine (III) (4.37 g, 0.02 mol),Sodium carbonate (8.74g, 0.1mol), CuBr (0.43g, 0.003mol), 1,10-phenanthroline (0.73g, 0.004mol). The temperature was raised to 150 C for 24h. The temperature was lowered to room temperature, water was slowly added to precipitate a solid, filtered, and dried to obtain a solid product (4.95 g, yield: 81.5%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 83255-86-1, 3-Bromo-1H-pyrazolo[3,4-d]pyrimidin-4-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Hangzhou China-USA East China Pharmaceutical Co., Ltd.; Yu Rui; Chen Yu; Wu Honghui; Hu Haiwen; Ye Kai; (6 pag.)CN110511225; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.83255-86-1, name is 3-Bromo-1H-pyrazolo[3,4-d]pyrimidin-4-amine, molecular formula is C5H4BrN5, molecular weight is 214.02, as common compound, the synthetic route is as follows.HPLC of Formula: C5H4BrN5

Intermediate 5 (2 g, 9.34 mmol), 4-phenoxyphenylboronic acid (4 g, 18.69 mmol),Pd(PPh3)4 (531 mg, 0.46 mmol), K3PO4.3H2O (7.45 g, 28.02 mmol),Add into a 250 ml two-necked flask and add 100 ml of solvent 1,4-dioxane: water = 4:1 (v/v) to dissolve.Nitrogen protection, ultrasonically removes oxygen from the solution, and replaces the air in the device with nitrogen.The oil was heated to reflux in a 135 C oil bath, and the reaction was completed after TLC detection for 30 h.The reaction mixture was cooled to room temperature, filtered over Celite, and evaporated.Obtained a pale yellow solid of 2.23 g, a yield of 78.8%.The elution system was dichloromethane: methanol = 100:1.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,83255-86-1, 3-Bromo-1H-pyrazolo[3,4-d]pyrimidin-4-amine, and friends who are interested can also refer to it.

Reference:
Patent; Shandong University; Zhao Guisen; Ran Fansheng; Liu Meixia; Liu Yang; Wang Luhua; (48 pag.)CN109369654; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia