Category: 83942-10-3

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 83942-10-3, name is 4,5-Dichloro-6-methylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 4,5-Dichloro-6-methylpyrimidine

PREPARATIVE EXAMPLE 4 5-chloro-6-methyl-4-[N-methyl-2-(2-methyl-4-n-propylphenoxy)ethylamino]pyrimidine (compound number 166) To a solution of 3.2 g (0.02 mol) of 4,5-dichloro-6-methylpyrimidine were added 2.0 g (0.02 mol) of triethylamine and 4.7 g (0.02 mol) of N-methyl-2-(2-methyl-4-n-propylphenoxy)ethylamine, and the mixture was melt-reacted by heating it for 5 minutes on a heater. Upon completion of the reaction, 100 ml of benzene were added to the reaction mixture, and insoluble matters were filtered off. The filtrate was washed with water, dried over anhydrous sodium sulphate, and the benzene distilled off under reduced pressure, leaving an oil. The oil was isolated by column chromatography (Wakogel C-200, eluted with a 3:1 by volume mixture of benzene and ethyl acetate) to give 6.1 g of the desired product in the form of a pale yellow oil nD23.8 1.5632

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 83942-10-3, 4,5-Dichloro-6-methylpyrimidine.

Reference:
Patent; Sankyo Company, Limited; Ube Industries, Limited; US4435402; (1984); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 83942-10-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 83942-10-3 as follows.

EXAMPLE 1 Synthesis of 5-Chloro-4-{2-[4-(2-ethoxyethyl)-2-methylphenoxy]ethylamino}-6-methylpyrimidine (Compound No. 12) 1.6 g of 4,5-dichloro-6-methylpyrimidine was dissolved in 50 ml of toluene. 1.0 g of triethylamine and 2.2 g of 2-[4-(2-ethoxyethyl)-2-methylphenoxy]ethylamine were added to the solution, and the reaction mixture was heated under reflux for 5 hours, whilst stirring. At the end of this time, the reaction mixture was washed with water and dried over anhydrous sodium sulfate. The toluene was removed by distillation under reduced pressure, and the oily product thus obtained was subjected to column chromatography (Wakogel C-200, eluted with a 2:1 by volume mixture of toluene and ethyl acetate) to isolate the product. The crystals thus obtained were recrystallized from hexane to afford 2.6 g of the title compound as colorless needles melting at 57-58 C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,83942-10-3, its application will become more common.

Reference:
Patent; Sankyo Company Limited; UBE Industries Limited; US4845097; (1989); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia