Category: 84955-31-7

Related Products of 84955-31-7 ,Some common heterocyclic compound, 84955-31-7, molecular formula is C6H5ClN4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE 2 4-Chloro-5-iodo-2-pivaloylamino-pyrrolo[2,3-d]pyrimidine (I) STR3 A solution of 2-amino-4-chloro-pyrrolo[2,3-d]pyrimidine (20 g, 118 mmol) and pivaloyl chloride (14.3 g, 118 mmol) in pyridine (150 mL) was stirred for 18 hours at ambient temperature. The resulting dark red solution was evaporated to an amber solid which was co-evaporated with water (20 mL, 3*). The resulting solid was filtered, washed with cold water and then dried over KOH in vacuo to yield 22 g (83%) of 2-pivaloylamino-4-chloro-pyrrolo[2,3-d]pyrimidine as a reddish solid. 1 H-NMR (DMSO-d6): delta 12.35 (bs, 1, N (7)-H); 10.07 (s,1, N (2)-H); 7.56 (m,1, H-6); 6.58 (m,1, H-5); 1.24 (s, 9, pivaloyl methyls).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,84955-31-7, its application will become more common.

Reference:
Patent; Isis Pharmaceuticals, Inc.; US6093807; (2000); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 84955-31-7, name is 4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine. A new synthetic method of this compound is introduced below., Formula: C6H5ClN4

To a suspension of 2-AMINO-4- CHLORO-7H-PYRROLO [2, 3-d] pyrimidine (1) (1.0 g, 6.0 mmol) in MeOH (50 mL) and aqueous ammonium hydroxide (1 mL) was added 10% Pd-C (500 mg). The reaction mixture was stirred under atmospheric pressure for 17 h and the catalyst was filtered through A pad of Celite. The filtrate was concentrated and chromatographed with silica gel (CH2CL2 : MEOH = 90: 10) to yield 717 mg of the target compound (90%). H NMR (DMSO-D6) : 8 11.4 (bs, 1H), 8. 50 (s, 1 H), 7.11 (dd, J= 3. 6,0. 6 HZ, 1H), 6.49 (bs, 2H), 6.32 (dd, J= 3. 6,0. 9 HZ, 1 H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 84955-31-7, 4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine.

Reference:
Patent; RIBAPHARM INC.; WO2004/80466; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia