Category: 852180-74-6

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 852180-74-6, name is 3-(Pyrimidin-5-yl)benzoic acid, the common compound, a new synthetic route is introduced below. Safety of 3-(Pyrimidin-5-yl)benzoic acid

To a stirred solution of XVII (0.100 g, 0.50 mmol) in 5 mL of DMF were added DIPEA (0.17 mL,1.0 mmol), HATU (0.380 g, 1.0 mmol) and XIII (0.203 g, 0.50 mmol) and stirred at RT for 12 h. Reactionmixture was diluted with ice-cold water and extracted with ethyl acetate (20 mL x 3). Organic layer wasthen washed with brine solution, dried over anhydrous sodium sulphate, concentrated under reducedpressure to afford crude product which was purified by reverse phase HPLC to afford desired product (0.053g, 18%).LCMS: 589 [M+1]+1H NMR (DMSO-d6): 10.50 (s, 1H), 10.20 (s, 1H), 9.25 (m, 3H), 8.43 (s, 1H), 8.20 (s, 1H), 8.10-8.05(m, 2H), 8.0 (m, 2H), 7.85 (d, 1H), 7.70 (m, 2H), 7.50 (d, 1H), 3.58 (s, 2H), 2.40-2.20 (m, 11H), 2.18 (s,3H).

The synthetic route of 852180-74-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ramachandran, Sreekanth A.; Jadhavar, Pradeep S.; Miglani, Sandeep K.; Singh, Manvendra P.; Kalane, Deepak P.; Agarwal, Anil K.; Sathe, Balaji D.; Mukherjee, Kakoli; Gupta, Ashu; Haldar, Srijan; Raja, Mohd; Singh, Siddhartha; Pham, Son M.; Chakravarty, Sarvajit; Quinn, Kevin; Belmar, Sebastian; Alfaro, Ivan E.; Higgs, Christopher; Bernales, Sebastian; Herrera, Francisco J.; Rai, Roopa; Bioorganic and Medicinal Chemistry Letters; vol. 27; 10; (2017); p. 2153 – 2160;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 852180-74-6, Adding some certain compound to certain chemical reactions, such as: 852180-74-6, name is 3-(Pyrimidin-5-yl)benzoic acid,molecular formula is C11H8N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 852180-74-6.

A mixture of 3-pyrimidin-5-yl-benzoic acid (100 mg, 0.50 mmol) and SOCl2 (73 mu, 1.0 mmol) was heated under reflux for 4 h. The solvent was evaporated off under reduced pressure and the residue was dissolved in DCM (5 mL) and slowly added to a mixture of 4- (chlorodifluoromethoxy)aniline (106 mg, 0.55 mmol) and TEA (140 mu, 1.0 mmol) in DCM (5 mL). The mixture was stirred at RT overnight. The solvent was evaporated off under reduced pressure and the residue was suspended in EtOAc (10 mL),filtered through a 10 muetaiota Isolute fritted cartridge and the filtrate was evaporated to dryness under reduced pressure to give the crude product which was purified by preparative HPLC to afford the title compound. LC-MS (Condition 4) tR = 1.15 min, m/z = 375.8 [M+H]+; XH-NMR (400 MHz, DMSO-d6) delta ppm 7.40 (d, J = 9.05 Hz, 2 H) 7.73 (t, J = 7.82 Hz, 1 H) 7.92 (m, 2 H) 8.06 (t, J = 6.97 Hz, 2 H) 8.37 (t, J = 1.96 Hz, 1 H) 9.24 – 9.29 (m, 3 H) 10.52 (s, 1 H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 852180-74-6, 3-(Pyrimidin-5-yl)benzoic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; FURET, Pascal; GROTZFELD, Robert Martin; JONES, Darryl Brynley; MANLEY, Paul; MARZINZIK, Andreas; MOUSSAOUI, Saliha; PELLE, Xavier Francois Andre; SALEM, Bahaa; SCHOEPFER, Joseph; WO2013/171641; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia