Category: 85426-79-5

Related Products of 85426-79-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 85426-79-5, name is 4-Chloro-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine, molecular formula is C6H5ClN4S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 3. Preparation of6-Methylsulfanyl-lH-pyrazolo[3,4-d]pyrimidine; EPO 4-Chloro-6-methylsulfanyl-lH-indazole (11.02 g, 0.0549 mol) was disolved in a mixture of 160 niL THF and 350 mLMeOH, and TFA (7.66 mL, 0.055 mol) was added. While the reaction mixture was stirred at RT under argon, palladium on activated carbon (2.0 g of 10% Pd, 0.001 mol) was added. The reaction mixture was stirred under H2 atmosphere for two hours, after which the reaction flask was flushed with argon, and another 2.0 g of palladium on activated carbon was added to the reaction mixture. The reaction mixture was again stirred for two hours under H2, after which the flask was purged with argon, another 2.0 g of palladium on activated carbon was added, and the reaction mixture was stirred for 64 hours under hydrogen. The reaction mixture was filtered through Celite, and the Celite pad was washed twice with 200 mL of warm MeOH and twice with 200 mL of warm methylene chloride. The combined organic phases were evaporated under reduced pressure. The residue was suspended in water, filtered, and the filter cake was suspended in heptane, filtered, and dried to yield 5.36 g of 6-Methylsulfanyl-lH-pyrazolo[3,4-d]pyri- midine. Mass Spec. M+H = 167.

According to the analysis of related databases, 85426-79-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2007/23105; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 85426-79-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 85426-79-5, name is 4-Chloro-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine, molecular formula is C6H5ClN4S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 3. Preparation of6-Methylsulfanyl-lH-pyrazolo[3,4-d]pyrimidine; EPO 4-Chloro-6-methylsulfanyl-lH-indazole (11.02 g, 0.0549 mol) was disolved in a mixture of 160 niL THF and 350 mLMeOH, and TFA (7.66 mL, 0.055 mol) was added. While the reaction mixture was stirred at RT under argon, palladium on activated carbon (2.0 g of 10% Pd, 0.001 mol) was added. The reaction mixture was stirred under H2 atmosphere for two hours, after which the reaction flask was flushed with argon, and another 2.0 g of palladium on activated carbon was added to the reaction mixture. The reaction mixture was again stirred for two hours under H2, after which the flask was purged with argon, another 2.0 g of palladium on activated carbon was added, and the reaction mixture was stirred for 64 hours under hydrogen. The reaction mixture was filtered through Celite, and the Celite pad was washed twice with 200 mL of warm MeOH and twice with 200 mL of warm methylene chloride. The combined organic phases were evaporated under reduced pressure. The residue was suspended in water, filtered, and the filter cake was suspended in heptane, filtered, and dried to yield 5.36 g of 6-Methylsulfanyl-lH-pyrazolo[3,4-d]pyri- midine. Mass Spec. M+H = 167.

According to the analysis of related databases, 85426-79-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2007/23105; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia