Category: 857641-46-4

Adding a certain compound to certain chemical reactions, such as: 857641-46-4, 2-(4-Bromo-1H-pyrazol-1-yl)pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2-(4-Bromo-1H-pyrazol-1-yl)pyrimidine, blongs to pyrimidines compound. Recommanded Product: 2-(4-Bromo-1H-pyrazol-1-yl)pyrimidine

A solution containing 2-(4-bromo-pyrazol-1-yl)-pyrimidine (300 mg, 1.34 mmol), 4-(4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolan-2-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (280 mg, 1.34 mmol), PdCI2(dppf) (95 mg, 0.13 mmol) and potassium phosphate (800 mg, 4 mmol) in dioxane was heated at 80 C under argon for overnight. After removed the solvent, ethylacetate was added and the mixture was filtered, washed with water.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,857641-46-4, 2-(4-Bromo-1H-pyrazol-1-yl)pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; SCHERING CORPORATION; WO2008/153858; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 857641-46-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 857641-46-4, name is 2-(4-Bromo-1H-pyrazol-1-yl)pyrimidine, molecular formula is C7H5BrN4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: The ligand pzpm (47.4mg, 0.32mmol) was dissolved in CH2Cl2 (10ml), and added to a suspension of [NiBr2(DME)] (100mg, 0.32mmol) in CH2Cl2 (20ml), in a Schlenk tube, under nitrogen. The reaction was stirred for 18h at room temperature. The resulting suspension was filtered and the solid product was washed twice with hexane (2×10ml) and dried in vacuum, yielding 94mg (82%) of a mustard yellow powder.

According to the analysis of related databases, 857641-46-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Moreno-Lara, Belen; Carabineiro, Sonia A.; Krishnamoorthy, Paramasivam; Rodriguez, Ana M.; Mano, Joao F.; Manzano, Blanca R.; Jalon, Felix A.; Gomes, Pedro T.; Journal of Organometallic Chemistry; vol. 799-800; (2015); p. 90 – 98;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia