Category: 86443-51-8

Baiazitov, Ramil; Du, Wu; Lee, Chang-Sun; Hwang, Seongwoo; Almstead, Neil G.; Moon, Young-Choon published an article in Synthesis. The title of the article was 《Chemoselective reactions of 4,6-dichloro-2-(methylsulfonyl)pyrimidine and related electrophiles with amines》.HPLC of Formula: 86443-51-8 The author mentioned the following in the article:

Chemoselective SNAr reactions of 4,6-dichloro-2-(methylsulfonyl)pyrimidine and several related electrophiles with amines and their derivatives are described. In the presence of weak bases anilines and secondary aliphatic amines selectively displace the chloride group. Deprotonated anilines and their carbonyl derivatives displace the sulfone group. Sterically and electronically unbiased primary aliphatic amines selectively displace the sulfone group in 4,6-dichloro-2-(methylsulfonyl)pyrimidine; however, their reactions with other electrophiles generally are less selective. Steric-driven selectivity explanation was proposed. The experimental process involved the reaction of 2-Chloro-N-ethylpyrimidin-4-amine(cas: 86443-51-8HPLC of Formula: 86443-51-8)

2-Chloro-N-ethylpyrimidin-4-amine(cas: 86443-51-8) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).HPLC of Formula: 86443-51-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 86443-51-8On May 31, 2017, Jarusiewicz, Jamie A.; Jeon, Jae Yoon; Connelly, Michele C.; Chen, Yizhe; Yang, Lei; Baker, Sharyn D.; Guy, R. Kiplin published an article in ACS Omega. The article was 《Discovery of a Diaminopyrimidine FLT3 Inhibitor Active against Acute Myeloid Leukemia》. The article mentions the following:

Profiling of the kinase-binding capabilities of an aminopyrimidine analog detected in a cellular screen of the St. Jude small-mol. collection led to the identification of a novel series of FMS-like tyrosine kinase 3 (FLT3) inhibitors. Structure-activity relationship studies led to the development of compounds exhibiting good potency against MV4-11 and MOLM13 acute myelogenous leukemia cells driven by FLT3, regardless of their FLT3 mutation status. In vitro pharmacol. profiling demonstrated that compound 5e shows characteristics suitable for further preclin. development. The experimental process involved the reaction of 2-Chloro-N-ethylpyrimidin-4-amine(cas: 86443-51-8Related Products of 86443-51-8)

2-Chloro-N-ethylpyrimidin-4-amine(cas: 86443-51-8) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Related Products of 86443-51-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Name: 2-Chloro-N-ethylpyrimidin-4-amineOn May 14, 2020 ,《Identification of 2-(4-(Phenylsulfonyl)piperazine-1-yl)pyrimidine Analogues as Novel Inhibitors of Chikungunya Virus》 appeared in ACS Medicinal Chemistry Letters. The author of the article were Moesslacher, Julia; Battisti, Verena; Delang, Leen; Neyts, Johan; Abdelnabi, Rana; Puerstinger, Gerhard; Urban, Ernst; Langer, Thierry. The article conveys some information:

Arylsulfonyl and aroyl piperazinylpyrimidines such as I were prepared as antiviral agents against the chikungunya virus, the causative agent of chikungunya fever, and for their toxicities to uninfected Vero cells. Optimization of an arylsulfonylpiperazinylpyrimidinamine lead compound yielded I with an EC50 value against chikungunya virus of 3.95μM and cytotoxicity in Vero cells of 260μM.2-Chloro-N-ethylpyrimidin-4-amine(cas: 86443-51-8Name: 2-Chloro-N-ethylpyrimidin-4-amine) was used in this study.

2-Chloro-N-ethylpyrimidin-4-amine(cas: 86443-51-8) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Name: 2-Chloro-N-ethylpyrimidin-4-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Hotra, Adam; Ragunathan, Priya; Ng, Pearly Shuyi; Seankongsuk, Pattarakiat; Harikishore, Amaravadhi; Sarathy, Jickky Palmae; Saw, Wuan-Geok; Lakshmanan, Umayal; Sae-Lao, Patcharaporn; Kalia, Nitin Pal; Shin, Joon; Kalyanasundaram, Revathy; Anbarasu, Sivaraj; Parthasarathy, Krupakar; Pradeep, Chaudhari Namrata; Makhija, Harshyaa; Droege, Peter; Poulsen, Anders; Tan, Jocelyn Hui Ling; Pethe, Kevin; Dick, Thomas; Bates, Roderick W.; Grueber, Gerhard published an article in Angewandte Chemie, International Edition. The title of the article was 《Discovery of a Novel Mycobacterial F-ATP Synthase Inhibitor and its Potency in Combination with Diarylquinolines》.Product Details of 86443-51-8 The author mentioned the following in the article:

The F1FO-ATP synthase is required for growth and viability of Mycobacterium tuberculosis and is a validated clin. target. A mycobacterium-specific loop of the enzyme’s rotary γ subunit plays a role in the coupling of ATP synthesis within the enzyme complex. We report the discovery of a novel antimycobacterial, termed GaMF1 (I), that targets this γ subunit loop. Biochem. and NMR studies show that GaMF1 inhibits ATP synthase activity by binding to the loop. GaMF1 is bactericidal and is active against multidrug- as well as bedaquiline-resistant strains. Chem. efforts on the scaffold revealed a dynamic structure activity relationship and delivered analogs with nanomolar potencies. Combining GaMF1 with bedaquiline or novel diarylquinoline analogs showed potentiation without inducing genotoxicity or phenotypic changes in a human embryonic stem cell reporter assay. These results suggest that GaMF1 presents an attractive lead for the discovery of a novel class of anti-tuberculosis F-ATP synthase inhibitors.2-Chloro-N-ethylpyrimidin-4-amine(cas: 86443-51-8Product Details of 86443-51-8) was used in this study.

2-Chloro-N-ethylpyrimidin-4-amine(cas: 86443-51-8) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Product Details of 86443-51-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Amide-based inhibitors of p38α MAP kinase. Part 2: Design, synthesis and SAR of potent N-pyrimidyl amides》 was written by Tester, Richland; Tan, Xuefei; Luedtke, Gregory R.; Nashashibi, Imad; Schinzel, Kurt; Liang, Weiling; Jung, Joon; Dugar, Sundeep; Liclican, Albert; Tabora, Jocelyn; Levy, Daniel E.; Do, Steven. Quality Control of 2-Chloro-N-ethylpyrimidin-4-amine And the article was included in Bioorganic & Medicinal Chemistry Letters on April 15 ,2010. The article conveys some information:

Optimization of a tri-substituted N-pyridyl amide led to the discovery of a class of potent N-pyrimidyl amide based p38α MAP kinase inhibitors, e.g., I. Initial SAR studies led to the identification of 5-dihydrofuran I as an optimal hydrophobic group. Addnl. side chain modifications resulted in the introduction of hydrogen bond interactions. Through extensive SAR studies, analogs bearing free amino groups and alternatives to the parent (S)-α-Me benzyl moiety were identified. These compounds exhibited improved cellular activities and maintained balance between p38α and CYP3A4 inhibition. In addition to this study using 2-Chloro-N-ethylpyrimidin-4-amine, there are many other studies that have used 2-Chloro-N-ethylpyrimidin-4-amine(cas: 86443-51-8Quality Control of 2-Chloro-N-ethylpyrimidin-4-amine) was used in this study.

2-Chloro-N-ethylpyrimidin-4-amine(cas: 86443-51-8) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Quality Control of 2-Chloro-N-ethylpyrimidin-4-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia