Category: 871254-61-4

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 871254-61-4, name is 2,4-Dichloropyrimidine-5-carbaldehyde. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 871254-61-4

To a solution of 2,4-dichloropyrimidine-5-carbaldehyde (20.2 g, 114 mmol) in THF (530 mL) at 0 C was added a chilled solution of hydrazine hydrate (11.5 g, 2 eq) in THF (230 mL) over 5 minutes. The reaction mixture was stirred 10 minutes at 0 C and 1 hour at room temperature. It was then diluted with EtOAc and H20 and the layers were separated. The aqueous layer was extracted with EtOAc then the combined organic phase was dried over Na2S04, filtered, and concentrated. The crude product was purified by normal-phase column chromatography on silica gel (50% EtO Ac/hexanes) to afford 6-chloro-lH- pyrazolo[3,4-d]pyrimidine as a light-yellow solid (8.8 g, 50% yield). 1HNMR (400 MHz, CD3OD) d (ppm): 9.17 (s, 1H), 8.30 (s, 1H).

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Reference:
Patent; RAPT THERAPEUTICS, INC.; BUI, Minna, H.T.; DUKES, Adrian, O.; HAN, Xinping; HU, Dennis, X.; JACKSON, Jeffrey, J.; KO, Yoo, Min; LEGER, Paul, R.; MA, Anqi; MAUNG, Jack; NG, Andrew, A.; OKANO, Akinori; ROBLES, Omar; SHIBUYA, Grant; SHUNATONA, Hunter, P.; SCHWARZ, Jacob, B.; SHAKHMIN, Anton, A.; WUSTROW, David, J.; ZIBINSKY, Mikhail; (0 pag.)WO2019/236631; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 871254-61-4, 2,4-Dichloropyrimidine-5-carbaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 871254-61-4, blongs to pyrimidines compound. Recommanded Product: 871254-61-4

The mixture of 9 (8.8 g, 50.0 mmol) and Et3N (15.2 g, 150.0 mmol)in THF (150 mL) was stirred at 0 C for 10 min under argon. To the solution was added 3-nitrobenzylhydrazine dihydrochloride (11.2 g,55.0 mmol) and then warm to r.t. and stirred for 4 h. The solvent wasremoved in vacuo, and the residue was partitioned between CH2Cl2(50 mL) and H2O (100 mL). The layers were separated, and the aqueouslayer was extracted with CH2Cl2 (2 × 50 mL). The combined organiclayers were dried over anhydrous sodium sulfate, filtered, and concentratedto provide the crude product, which was purified by silica gelcolumn chromatography (eluting with 0-10% MeOH in DCM) to provide10a, white solid, yield 62% (9.0 g, 31.1 mmol). 1H NMR(300 MHz, CDCl3) delta 8.93 (s, 1H), 8.25 (m, 1H), 8.18 (m, 1H), 8.07 (s,1H), 7.71 (d, J = 9 Hz, 1H), 7.53 (t, J = 9 Hz, 1H), 5.71 (s, 2H); MS(ESI) m/z: 290.1 [M+H]+.

The synthetic route of 871254-61-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yin, Yuan; Chen, Cheng-Juan; Yu, Ru-Nan; Shu, Lei; Wang, Zhi-Jian; Zhang, Tian-Tai; Zhang, Da-Yong; Bioorganic Chemistry; vol. 98; (2020);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 871254-61-4, name is 2,4-Dichloropyrimidine-5-carbaldehyde, molecular formula is C5H2Cl2N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C5H2Cl2N2O

To a stirred solution of 2,4-dichloropyrimidine-5-carbaldehyde (200 mg, 1.20 mmol) in DMF (4 mL) under an inert atmosphere was added N1-cyclopropyl-5-fluorobenzene-1,2-diamine Int-1 (320 mg, 1.80 mmol) and oxone (738 mg, 2.40 mmol) followed by water (0.4 mL) at room temperature. The reaction mixture was stirred at room temperature for 3 h. After consumption of starting material (by TLC), the reaction mixture was diluted with water (20 mL) and extracted with EtOAc (2*20 mL). The combined organic extracts were dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude material was purified by silica gel column chromatography (eluent: 30% EtOAc/hexane) to afford 1-cyclopropyl-2-(2,4-dichloropyrimidin-5-yl)-6-fluoro-1H-benzo[d]imidazole Ex. 35 (180 mg, 0.55 mmol, 46%) as brown solid. ?H NMR (400 MHz, CDC13): oe 8.80 (s, 1H),7.78-7.74 (m, 1H), 7.32 (dd, J=8.5, 2.4 Hz, 1H), 7.14-7.10(m, 1H), 3.55-3.36 (m, 1H), 1.12-1.07 (m, 2H), 0.79-0.68(m, 2H) EC-MS: mlz 324.9 [M+2H] at 2.53 RT (97.74% purity). HPEC: 95.01%.

With the rapid development of chemical substances, we look forward to future research findings about 871254-61-4.

Reference:
Patent; Viamet Pharmaceuticals (NC), Inc.; Sparks, Steven; Yates, Christopher M.; Shaver, Sammy R.; (93 pag.)US2018/186773; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 871254-61-4, Adding some certain compound to certain chemical reactions, such as: 871254-61-4, name is 2,4-Dichloropyrimidine-5-carbaldehyde,molecular formula is C5H2Cl2N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 871254-61-4.

To a flask containing MeOH (24.0 mL), was added 2,4- dichloropyrimidine-5-carbaldehyde (1.5159 g, 1.0 equiv.), PPTS (215.0 mg, 0.1 equiv.) and trimethyl orthoformate (6.0 mL). The reaction mixture was stirred at 65 C for 14 h, cooled to rt and concentrated. The resulting residue was purified via column chromatography to yield the title compound as an oil (1.4361 g, 75% yield). NMR (400 MHz, Chloroform-^ d 8.73 (s, 1H), 5.54 (s, 1H), 3.38 (s, 7H). LC-MS: m/z 223, 225 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 871254-61-4, 2,4-Dichloropyrimidine-5-carbaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AGIOS PHARMACEUTICALS, INC.; KONTEATIS, Zenon D.; LI, Mingzong; LIU, Peng; MEDEIROS, Matthew; REZNIK, Samuel K.; SUI, Zhihua; TRAVINS, Jeremy M.; POPOVICI-MULLER, Janeta; ZHOU, Shubao; MA, Guangning; (298 pag.)WO2019/191470; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 871254-61-4, Adding some certain compound to certain chemical reactions, such as: 871254-61-4, name is 2,4-Dichloropyrimidine-5-carbaldehyde,molecular formula is C5H2Cl2N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 871254-61-4.

Example 18 6-Chloro-1H-pyrazolo[3,4-d]pyrimidine To a stirred solution of hydrazine (Aldrich, 64 mg, 2 mmol) in THF (5 mL), 2,4-Dichloro-pyrimidine-5-carbaldehyde (Example 17, 176 mg, 1 mmol) was added and the mixture was stirred at room temperature for 30 min. The mixture was poured into water and extracted with EtOAc. The extract was dried with sodium sulfate and the solvent was removed to give an orange solid. 128 mg, 82%. MS (M+H)+, 155.

According to the analysis of related databases, 871254-61-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Ding, Qingjie; Jiang, Nan; Roberts, John Lawson; US2005/277655; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding some certain compound to certain chemical reactions, such as: 871254-61-4, name is 2,4-Dichloropyrimidine-5-carbaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 871254-61-4. 871254-61-4

Example 18 6-Chloro-1H-pyrazolo[3,4-d]pyrimidine To a stirred solution of hydrazine (Aldrich, 64 mg, 2 mmol) in THF (5 mL), 2,4-Dichloro-pyrimidine-5-carbaldehyde (Example 17, 176 mg, 1 mmol) was added and the mixture was stirred at room temperature for 30 min. The mixture was poured into water and extracted with EtOAc. The extract was dried with sodium sulfate and the solvent was removed to give an orange solid. 128 mg, 82%. MS (M+H)+, 155.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 871254-61-4.

Reference:
Patent; Ding, Qingjie; Jiang, Nan; Roberts, John Lawson; US2005/277655; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia