Category: 873-83-6

Adding a certain compound to certain chemical reactions, such as: 873-83-6, 6-Aminopyrimidine-2,4(1H,3H)-dione, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 873-83-6, blongs to pyrimidines compound. Recommanded Product: 873-83-6

General procedure: In a reaction vessel, a mixture of 6-aminouracil (2 mmol),aldehyde (1 mmol), and SBA-15-SO3H (0.05 g) was heatedat 120 °C under solvent-free conditions for a specified time(completion of the reaction was monitored by TLC). Aftercompletion of the reaction, hot DMF (5 mL) was added andthe catalyst was separated by simple filtration. Then water(15 mL) was added to the filtrate to give the solid product.

The synthetic route of 873-83-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Rostamizadeh, Shahnaz; Tahershamsi, Leili; Zekri, Negar; Journal of the Iranian Chemical Society; vol. 12; 8; (2015); p. 1381 – 1389;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 873-83-6 , The common heterocyclic compound, 873-83-6, name is 6-Aminopyrimidine-2,4(1H,3H)-dione, molecular formula is C4H5N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A mixture of aromatic aldehyde (1 mmol), malononitrile (0.66 g, 1 mmol), 6-aminouracil(1 mmol), and KBr (0.1 g, 1 mmol) in EtOH (15 mL) was electrolyzed at 78 °C in an undividedcell equipped with a magnetic stirrer, a platinum anode and a zinc cathode under a constantcurrent density of 5 mA cm-2. The progress of the reaction was monitored by thin layerchromatography. After the electrolysis was finished, the mixture was filtered and the filtercake was washed twice with an ethanol/water (1:1) solution to yield pure products 4a?j.

The synthetic route of 873-83-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kazemi-Rad, Reyhaneh; Azizian, Javad; Kefayati, Hassan; Journal of the Serbian Chemical Society; vol. 81; 1; (2016); p. 29 – 34;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 873-83-6 ,Some common heterocyclic compound, 873-83-6, molecular formula is C4H5N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A mixture of 6-aminouracil 1 (2 mmol), aromatic aldehyde 2 (2 mmol), urea (3, 2.5 mmol) and CuI NPs (2.9 mg,15 molpercent) in water (4 mL) was stirred at room temperature for the appropriate time. The progress of the reaction was monitored by TLC. After completion of the reaction,the resulting mixture was filtered. The solid residue was diluted with DMF (10 mL) and centrifuged at 2000?3000 rpm for 5 min to remove the CuI catalyst which was washed with DMF and dried at 100 °C for several hours in a vacuum for reuse. The organic solution was then poured into ice-cold water (10 mL) to give a solid precipitate, which was filtered off and recrystallized from DMF and H2O to afford the pure product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 873-83-6, 6-Aminopyrimidine-2,4(1H,3H)-dione, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Abdolmohammadi, Shahrzad; Afsharpour, Maryam; Zeitschrift fur Naturforschung, B: Chemical Sciences; vol. 70; 3; (2015); p. 171 – 176;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 873-83-6, name is 6-Aminopyrimidine-2,4(1H,3H)-dione. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 6-Aminopyrimidine-2,4(1H,3H)-dione

6-Aminouracil (5) (5.18 g, 40.7 mmol) was suspended in HM DS (25 mL) and H2S04 (0.1 m L) was added. The mixture was heated at reflux for 3 h then concentrated in vacuo. The residue was dissolved in DM F (30 mL), Mel (8.5 mL, 136.5 mmol) was added, and stirring was continued for 72 h at room temperature. The reaction was cooled to 0 C and NaHC03 was carefully added. The mixture was stirred at 0 C until no more bubbling was observed. The precipitate was filtered, washed with MeOH and H20 and dried to give the title compound 6 (4.49 g, 78%) as a yellow solid which was used without further purification.Rf 0.23 (EtOAc-MeOH-N H4OH, 7:2.7:0.3);H NMR (400 MHz, DMSO-d6) delta 10.36 (1H, s, Ntf), 6.16 (2H, s, Ntf2), 4.56 (1H, s, tf-5); 3.04 (3H, s, NCtf3); 13C NMR (100 M Hz, DMSO-d6) delta 163.3 (C-4), 153.5 (C-6), 151.1 (C-2), 74.0 (C-5), 25.9 (NCH3);MP Lit: 327 C19, found: 320-323 C;

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 873-83-6, 6-Aminopyrimidine-2,4(1H,3H)-dione.

Reference:
Patent; COMVITA LIMITED; BRIMBLE, Margaret Anne; SCHLOTHAUER, Ralf Christian; PRIJIC, Gordana; STEPHENS, Jonathan; DANIELS, Benjamin; (57 pag.)WO2017/99612; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 873-83-6, Adding some certain compound to certain chemical reactions, such as: 873-83-6, name is 6-Aminopyrimidine-2,4(1H,3H)-dione,molecular formula is C4H5N3O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 873-83-6.

General procedure: In a reaction vessel, a mixture of 6-aminouracil (2 mmol),aldehyde (1 mmol), and SBA-15-SO3H (0.05 g) was heatedat 120 C under solvent-free conditions for a specified time(completion of the reaction was monitored by TLC). Aftercompletion of the reaction, hot DMF (5 mL) was added andthe catalyst was separated by simple filtration. Then water(15 mL) was added to the filtrate to give the solid product.

According to the analysis of related databases, 873-83-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Rostamizadeh, Shahnaz; Tahershamsi, Leili; Zekri, Negar; Journal of the Iranian Chemical Society; vol. 12; 8; (2015); p. 1381 – 1389;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 873-83-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 873-83-6, name is 6-Aminopyrimidine-2,4(1H,3H)-dione. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: In a reaction vessel, a mixture of 6-aminouracil (2 mmol),aldehyde (1 mmol), and SBA-15-SO3H (0.05 g) was heatedat 120 °C under solvent-free conditions for a specified time(completion of the reaction was monitored by TLC). Aftercompletion of the reaction, hot DMF (5 mL) was added andthe catalyst was separated by simple filtration. Then water(15 mL) was added to the filtrate to give the solid product.

According to the analysis of related databases, 873-83-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Rostamizadeh, Shahnaz; Tahershamsi, Leili; Zekri, Negar; Journal of the Iranian Chemical Society; vol. 12; 8; (2015); p. 1381 – 1389;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 873-83-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 873-83-6, name is 6-Aminopyrimidine-2,4(1H,3H)-dione, molecular formula is C4H5N3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

196 g of water and 4 g of PTS were added to a 500 ml glass reactor equipped with mechanical stirring, stirred at 70 C for 2 hours, cooled to 55 C, and solid 6-aminouracil (20.0 g, 1.0 eq., 157.4 mmol) was added and stirred to form a suspension. Then, benzaldehyde (10.0 g, 0.6 eq., 94.4 mmol) was added and stirred at 55 C for 5-8 hours at high speed to obtain an off-white suspension. The progress of the reaction was confirmed by HPLC or TLC to ensure complete conversion of the starting material, cooling to 30 C, filtration The filter cake was washed with 30 ml of hot water, and the wet cake was air-dried at 100 C for 3 hours to obtain 24.0 g of a white solid with a purity of 97.9% and a yield of 89.1%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 873-83-6, 6-Aminopyrimidine-2,4(1H,3H)-dione.

Reference:
Patent; Guangzhou Zhenlaimai New Materials Technology Co., Ltd.; Xiao Juan; Qi Tafamingrenqingqiubugongkaixingming; (11 pag.)CN110041270; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 873-83-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.873-83-6, name is 6-Aminopyrimidine-2,4(1H,3H)-dione, molecular formula is C4H5N3O2, molecular weight is 127.1, as common compound, the synthetic route is as follows.

General procedure: A mixture of isatin (0.147 g, 1 mmol), acetophenone (0.09 mL, 1.5 mmol), and piperidine (two drops, 0.1 mmol) in ethanol (95.5percent, 1 mL) was heated at 80 ¡ãC for about 5 min. To the solid obtained at this stage was added 6-amino-1,3-dimethyluracil (0.155 g, 1 mmol), p-toluenesulfonic acid monohydrate (0.076 g, 0.04 mmol), and EtOH (95.5percent, 2 mL). The mixture was stirred and heated gently at 80 ¡ãC. After completion of the reaction (115 min), as monitored by TLC using 5:1 ratio of ethyl acetate/n-hexane, the reaction mixture was cooled to room temperature and then filtered. The separated solids were washed twice with 10 mL of water and 3 mL of hot ethanol (95.5percent) to obtain the pure product 4a.

Statistics shows that 873-83-6 is playing an increasingly important role. we look forward to future research findings about 6-Aminopyrimidine-2,4(1H,3H)-dione.

Reference:
Article; Rad-Moghadam, Kurosh; Azimi, Seyyedeh Cobra; Tetrahedron; vol. 68; 47; (2012); p. 9706 – 9712;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 873-83-6 ,Some common heterocyclic compound, 873-83-6, molecular formula is C4H5N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A mixture of 4-aminocoumarin /6-aminouracil (1.0 mmol), isatin/5-bromoisatin (1.0 mmol), 1,3-diketo compound (cyclohexane-1,3-dione, indane-1,3-dione, dimedone, 1,3-dimethylbarbituric acid)(1.0 mmol) and PEG?OSO3H (15 molpercent) was taken in 5 ml water. The mixture was stirred at 70 oC for a required period of time (TLC). After completion of each reaction, the crude product (insoluble in water) was filtered and it was washed with ethanol. The isolated product was recrystallized from DMF?water to get the pure product.#10;#10;#10;

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,873-83-6, its application will become more common.

Reference:
Article; Paul, Sanjay; Das, Asish R.; Tetrahedron Letters; vol. 54; 9; (2013); p. 1149 – 1154;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In an article, author is Hu, Zilun, once mentioned the application of 873-83-6, Name is 6-Aminopyrimidine-2,4(1H,3H)-dione, molecular formula is C4H5N3O2, molecular weight is 127.1, MDL number is MFCD00006071, category is pyrimidines. Now introduce a scientific discovery about this category, Safety of 6-Aminopyrimidine-2,4(1H,3H)-dione.

Identification of 5H-chromeno[3,4-c]pyridine and 6H-isochromeno [3,4-c] pyridine derivatives as potent and selective dual ROCK inhibitors

A novel series of 5H-chromeno[3,4-c]pyridine, 6H-isochromeno[3,4-c]pyridine and 6H-isochromeno [4,3-d] pyrimidine derivatives as dual ROCK1 and ROCK2 inhibitors is described. Optimization led to compounds with sub-nanomolar inhibitory affinity for both kinases and excellent kinome selectivity. Compound 19 exhibited ROCK1 and ROCK2 IC50 of 0.67 nM and 0.18 nM respectively.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia