Category: 873-83-6

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Recommanded Product: 6-Aminopyrimidine-2,4(1H,3H)-dione873-83-6, Name is 6-Aminopyrimidine-2,4(1H,3H)-dione, SMILES is O=C1NC(C=C(N)N1)=O, belongs to pyrimidines compound. In a article, author is Xu, Ze, introduce new discover of the category.

Boosting Visible-Light-Driven H-2 Evolution of Covalent Triazine Framework from Water by Modifying Ni(II) Pyrimidine-2-thiolate Cocatalyst

Covalent triazine frameworks (CTFs) have recently emerged as prospective photoactive materials coupled with Pt or Pd cocatalyst for the hydrogen evolution. Herein, we report visible-light driven hydrogen generation catalyzed by heterogeneous systems combining CTF photosensitizers and a noble-metal-free cocatalyst for the first time. CTF-HC2 was doped with two-dimensional Ni(II) pyrimidine-2-thiolate ([Ni(pymt)(2)](n)) to yield a series of x-[Ni(pymt)(2)](n)/CTF-HC2 (x=3, 6, 9, 12, 15, 18 and 24 wt %) composites. Illuminated with lambda>420 nm, [Ni(pymt)(2)](n)/CTF-HC2 materials display excellent photocatalytic performance for H-2 generation from water. The highest hydrogen evolution rate is up to 3472 mu mol h(-1) g(-1), which is 68 times of bare CTF-HC2 (51 mu mol h(-1) g(-1)) and 1.16 times of CTF-HC2 doped 2.0 wt % Pt (2991 mu mol h(-1) g(-1)). The efficient and recyclable heterogeneous photocatalytic H-2 production from water under visible light has been established.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 873-83-6. Recommanded Product: 6-Aminopyrimidine-2,4(1H,3H)-dione.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Product Details of 873-83-6, 873-83-6, Name is 6-Aminopyrimidine-2,4(1H,3H)-dione, molecular formula is C4H5N3O2, belongs to pyrimidines compound. In a document, author is Mohamed, Mosselhi A. M., introduce the new discover.

Nucleosides 11: synthesis of new derivatives of pyrido[2,3-d]pyrimidines and their nucleosides

Reaction of 6-amino-2-methylthio-3-methyluracil with ethyl ethoxymethyleneoxaloacetate or methyl(Z)-2-acetylamino-3-dimethylaminopropenoates afforded diethyl 2-(1,6-dihydro-1-methyl-2-(methylthio)-6-oxopyrimidin-4-yl-amino)methylene malonate or (2E)-methyl 3-(1,6-dihydro-1-methyl-2-(methylthio)-6-oxopyrimidin-4-yl-amino)-2-acetamidoacrylate, respectively. Cyclization of each of the latter products by sodium ethoxide afforded new pyrido [2,3-d]pyrimidines, which were ribosylated with 1-O-acetyl-2,3,5-O-benzoyl-beta-D-ribofuranose by the silylation method yielded the protected nucleosides. The protected nucleosides were debenzoylated by sodium methoxide to afford novel pyrido[2,3-d]pyrimidine nucleosides. The structural assignmentsv for the new compounds were based on their elemental analysis and spectroscopic data.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 873-83-6. Product Details of 873-83-6.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 873-83-6, Name is 6-Aminopyrimidine-2,4(1H,3H)-dione, molecular formula is C4H5N3O2. In an article, author is Naes, Safaa M.,once mentioned of 873-83-6, Quality Control of 6-Aminopyrimidine-2,4(1H,3H)-dione.

Equilibrative Nucleoside Transporter 2: Properties and Physiological Roles

Equilibrative nucleoside transporter 2 (ENT2) is a bidirectional transporter embedded in the biological membrane and is ubiquitously found in most tissue and cell types. ENT2 mediates the uptake of purine and pyrimidine nucleosides and nucleobase besides transporting a variety of nucleoside-derived drugs, mostly in anticancer therapy. Since high expression of ENT2 has been correlated with advanced stages of different types of cancers, consequently, this has gained significant interest in the role of ENT2 as a potential therapeutic target. Furthermore, ENT2 plays critical roles in signaling pathway and cell cycle progression. Therefore, elucidating the physiological roles of ENT2 and its properties may contribute to a better understanding of ENT2 roles beyond their transportation mechanism. This review is aimed at highlighting the main roles of ENT2 and at providing a brief update on the recent research.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.873-83-6, Name is 6-Aminopyrimidine-2,4(1H,3H)-dione, SMILES is O=C1NC(C=C(N)N1)=O, belongs to pyrimidines compound. In a document, author is Ontiveros, Robert J., introduce the new discover, Recommanded Product: 6-Aminopyrimidine-2,4(1H,3H)-dione.

Identification and Characterization of a Minimal Functional Splicing Regulatory Protein, PTBP1

Polypyrimidine tract binding protein 1 (PTBP1) is a well-studied RNA binding protein that serves as an important model for understanding molecular mechanisms underlying alternative splicing regulation. PTBP1 has four RNA binding domains (RBDs) connected via linker regions. Additionally, PTBP1 has an N-terminal unstructured region that contains nuclear import and export sequences. Each RBD can bind to pyrimidine rich elements with high affinity to mediate splicing activity. Studies support a variety of models for how PTBP1 can mediate splicing regulation on target exons. Obtaining a detailed atomic view hinges on determining a crystal structure of PTBP1 bound to a target RNA transcript. Here, we created a minimal functional PTBP1 with deletions in both linker 1 and linker 2 regions and assayed for activity on certain regulated exons, including the c-Src Ni exon. We show that for a subset of PTBP1-regulated exons the linker regions are not necessary for splicing repression activity. Gel mobility shift assays reveal the linker deletion mutant binds with 12-fold higher affinity to a target RNA sequence compared to wild-type PTBP1. A minimal PTBP1 that also contains an N-terminal region deletion binds to a target RNA with an affinity higher than that of wild-type PTBP1. Moreover, this minimal protein oligomerizes readily to form a distinct higher-order complex previously shown to be required for mediating splicing repression. This minimal functional PTBP1 protein can serve as a candidate for future structure studies to understand the mechanism of splicing repression for certain regulated exons.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 873-83-6 is helpful to your research. Recommanded Product: 6-Aminopyrimidine-2,4(1H,3H)-dione.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 873-83-6, Name is 6-Aminopyrimidine-2,4(1H,3H)-dione, molecular formula is , belongs to pyrimidines compound. In a document, author is Kantas, Boglarka, Formula: C4H5N3O2.

In Silico, In Vitro and In Vivo Pharmacodynamic Characterization of Novel Analgesic Drug Candidate Somatostatin SST4 Receptor Agonists

Background: Somatostatin released from the capsaicin-sensitive sensory nerves mediates analgesic and anti-inflammatory effects via its receptor subtype 4 (SST4) without influencing endocrine functions. Therefore, SST4 is considered to be a novel target for drug development in pain, especially chronic neuropathy which is a great unmet medical need. Purpose and Experimental Approach: Here, we examined the in silico binding, SST4-linked G protein activation and beta-arrestin activation on stable SST4 expressing cells and the effects of our novel pyrrolo-pyrimidine molecules (20, 100, 500, 1,000, 2,000 mu g center dot kg(-1)) on partial sciatic nerve ligation-induced traumatic mononeuropathic pain model in mice. Key Results: The novel compounds bind to the high affinity binding site of SST4 the receptor and activate the G protein. However, unlike the reference SST4 agonists NNC 26-9100 and J-2156, they do not induce beta-arrestin activation responsible for receptor desensitization and internalization upon chronic use. They exert 65-80% maximal anti-hyperalgesic effects in the neuropathy model 1 h after a single oral administration of 100-500 mu g center dot kg(-1) doses. Conclusion and Implications: The novel orally active compounds show potent and effective SST4 receptor agonism in vitro and in vivo. All four novel ligands proved to be full agonists based on G protein activation, but failed to recruit beta-arrestin. Based on their potent antinociceptive effect in the neuropathic pain model following a single oral administration, they are promising candidates for drug development.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 873-83-6, Name is 6-Aminopyrimidine-2,4(1H,3H)-dione, SMILES is O=C1NC(C=C(N)N1)=O, in an article , author is Elkina, Natalia A., once mentioned of 873-83-6, Recommanded Product: 873-83-6.

Competitive routes to cyclizations of polyfluoroalkyl-containing 2-tolylhy-drazinylidene-1,3-diketones with 3-aminopyrazoles into bioactive pyrazoloazines

The reaction of polyfluomalkyl-containing 2-tolylhydrazinylidene-1,3-diketones with 3-aminopyrazoles depending on their structure can proceed as N,N-cyclization to form 5-R-F- and 7-R-F-regioisomeric pyrazolo [1,5-a]pyrimidines (at that haloform cleavage to non-fluorinated pyrazolo[1,5-a]pyrimidine-7-ones is typical of 7-polyfluoroalkyl-containing isomers) or as C,N-cyclization to give 4-polyfluoroalkylpyrazolo [3,4-b]pyridines. The analogous transformations of non-fluorinated 3-tolylhydrazinylidenepentane-2,4-dione led to pyrazolo [1,5-a] pyrimidines only. Antiviral effect against influenza and Coxsackie viruses, analgesic activity and acute toxicity of some synthesized pyrazoloazines were evaluated.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 873-83-6, you can contact me at any time and look forward to more communication. Recommanded Product: 873-83-6.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 873-83-6, Name is 6-Aminopyrimidine-2,4(1H,3H)-dione, formurla is C4H5N3O2. In a document, author is Sun, Qiushi, introducing its new discovery. Safety of 6-Aminopyrimidine-2,4(1H,3H)-dione.

An Ion Chromatography-Ultrahigh-Resolution-MS1/Data-Independent High-Resolution MS2 Method for Stable Isotope-Resolved Metabolomics Reconstruction of Central Metabolic Networks

The metabolome comprises a complex network of interconnecting enzyme-catalyzed reactions that involve transfers of numerous molecular subunits. Thus, the reconstruction of metabolic networks requires metabolite substructures to be tracked. Subunit tracking can be achieved by tracing stable isotopes through metabolic transformations using NMR and ultrahigh -resolution (UHR)-mass spectrometry (MS). UHR-MS1 readily resolves and counts isotopic labels in metabolites but requires tandem MS to help identify isotopic enrichment in substructures. However, it is challenging to perform chromatography-based UHR-MS1 with its long acquisition time, while acquiring MS2 data on many coeluting labeled isotopologues for each metabolite. We have developed an ion chromatography (IC)-UHR-MS1/data-independent(DI)-HR-MS2 method to trace the fate of C-13 atoms from [C-13(6)]-glucose ([C-13(6)]-Glc) in 3D A549 spheroids in response to anticancer selenite and simultaneously C-13/N-15 atoms from [C-13(5), N-15(2)]-glutamine ([C-13(5), N-13(2)]-Gln) in 2D BEAS-2B cells in response to arsenite transformation. This method retains the complete isotopologue distributions of metabolites via UHR-MS1 while simultaneously acquiring substructure label information via DI-MS2. These details in metabolite labeling patterns greatly facilitate rigorous reconstruction of multiple, intersecting metabolic pathways of central metabolism, which are illustrated here for the purine/pyrimidine nucleotide biosynthesis. The pathways reconstructed based on subunit-level isotopologue analysis further reveal specific enzyme-catalyzed reactions that are impacted by selenite or arsenite treatments.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

In an article, author is de Sousa, Eduardo C., once mentioned the application of 873-83-6, Safety of 6-Aminopyrimidine-2,4(1H,3H)-dione, Name is 6-Aminopyrimidine-2,4(1H,3H)-dione, molecular formula is C4H5N3O2, molecular weight is 127.1, MDL number is MFCD00006071, category is pyrimidines. Now introduce a scientific discovery about this category.

Nucleobase coupling by Mitsunobu reaction towards nucleoside analogs

The coupling of a nucleobase is a key step in the synthesis of most nucleoside analogs, e.g. carbocyclic nucleosides, isonucleosides and acyclic nucleosides. The synthetic strategies for nucleosides based on N-glycosylation are not applied when the nucleobase is not linked to the anomeric center. Thus, other methods have been employed, mainly those based on the alkylation of nucleobases. The Mitsunobu reaction, in which a hydroxy group is replaced by a nucleophile, has also been extensively applied, generating a diversity of molecules, including pharmaceuticals and their precursors. In this review the usefulness of this reaction for the coupling of nucleobases to non-anomeric positions of sugars, carbasugars and other homocyclic and linear structures is highlighted and discussed, covering purines and pyrimidines as pronucleophiles. [GRAPHICS] .

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Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Related Products of 873-83-6 ,Some common heterocyclic compound, 873-83-6, molecular formula is C4H5N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A mixture of 2-hydroxynaphthalene-1,4-dione (0.17 g, 1 mmol), 4-chlorobezaldehyde(0.14 g, 1 mmol), 6-amino-uracil (0.12 g, 1 mmol), and p-TSA (0.05 g) in refluxing water (5 mL) was stirred for 6 h. After completion of the reaction as confirmed by thin-layer chromatography (TLC) (eluent EtOAc=n-hexane, 1:3), the reaction mixture was cooled to room temperature. The precipitated product was separated by filtration, washed three times with water and 5mL acetone, and dried at 60?70 ¡ãC. Corresponding products were analytically pure without recrystallization.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,873-83-6, its application will become more common.

Reference:
Article; Azizian, Javad; Delbari, Akram Sadat; Yadollahzadeh, Khadijeh; Synthetic Communications; vol. 44; 22; (2014); p. 3277 – 3286;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 873-83-6, 6-Aminopyrimidine-2,4(1H,3H)-dione, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C4H5N3O2, blongs to pyrimidines compound. Formula: C4H5N3O2

General procedure: A mixture of isatin (0.147 g, 1 mmol), acetophenone (0.09 mL, 1.5 mmol), and piperidine (two drops, 0.1 mmol) in ethanol (95.5percent, 1 mL) was heated at 80 ¡ãC for about 5 min. To the solid obtained at this stage was added 6-amino-1,3-dimethyluracil (0.155 g, 1 mmol), p-toluenesulfonic acid monohydrate (0.076 g, 0.04 mmol), and EtOH (95.5percent, 2 mL). The mixture was stirred and heated gently at 80 ¡ãC. After completion of the reaction (115 min), as monitored by TLC using 5:1 ratio of ethyl acetate/n-hexane, the reaction mixture was cooled to room temperature and then filtered. The separated solids were washed twice with 10 mL of water and 3 mL of hot ethanol (95.5percent) to obtain the pure product 4a.

The synthetic route of 873-83-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Rad-Moghadam, Kurosh; Azimi, Seyyedeh Cobra; Tetrahedron; vol. 68; 47; (2012); p. 9706 – 9712;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia