Category: 87591-84-2

Electric Literature of 87591-84-2, Adding some certain compound to certain chemical reactions, such as: 87591-84-2, name is 2-(Chloromethyl)-8-methyl-4H-pyrido[1,2-a]pyrimidin-4-one,molecular formula is C10H9ClN2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 87591-84-2.

A solution of 1H-benzo[d]imidazole (60.0 mg, 0.508 mmol), 2-(chloromethyl)-8-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (CAS 87591-84-2, 74.7 mg, 0.358 mmol), and powdered potassium carbonate (106.3 mg, 0.769 mmol) in DMF (2.50 mL) was stirred in a sealed tube at room temperature for 64 hours. The solution was diluted with methanol to 5 mL, filtered, and purified by reverse-phase HPLC to give 9 (79.8 mg, 54%) as an off-white solid. 1H NMR (400 MHz, DMSO-d6) ppm 2.43 (s, 3 H) 5.49 (s, 2 H) 5.99 (s, 1 H) 7.18 – 7.25 (m, 3 H) 7.46 (s, 1 H) 7.53 – 7.58 (m, 1 H) 7.66 – 7.70 (m, 1 H) 8.36 (s, 1 H) 8.81 (d, J=7.33 Hz, 1 H). HRMS: [M+H]+ calc. 291.124038, found 291.124138, error 0.34 ppm.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 87591-84-2, 2-(Chloromethyl)-8-methyl-4H-pyrido[1,2-a]pyrimidin-4-one, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Guo, Chuangxing; Linton, Angelica; Jalaie, Mehran; Kephart, Susan; Ornelas, Martha; Pairish, Mason; Greasley, Samantha; Richardson, Paul; Maegley, Karen; Hickey, Michael; Li, John; Wu, Xin; Ji, Xiaodong; Xie, Zhi; Bioorganic and Medicinal Chemistry Letters; vol. 23; 11; (2013); p. 3358 – 3363;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 87591-84-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 87591-84-2, name is 2-(Chloromethyl)-8-methyl-4H-pyrido[1,2-a]pyrimidin-4-one, molecular formula is C10H9ClN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

[0400] To a solution of I -(2-methoxyphenyl)-5-(thiophen-2-yl)- 1 H-imidazole-2-thiol (50.0 mg, 0.17 mmol) in acetone (2 mL) was added 2-(chloromethyl)-8-methyl-4H- pyrido[l,2-a]pyrimidin-4-one (40 mg, 0.19 mmol) and K2C03 (71 rng, 0.51 mmol). Then the mixture was warmed to 60 C and stirred until the reaction was completed (2hrs). Aftet cooling to room temperature, the reactant was filtered and the filtrate was concentrated to dryness in vacuum. The residue was diluted with EA (5 rnL) and the suspension was washed with aqueous 5% NaOH (5 mL), brine (5 mL). The organic layer was dried over anhydrous Na2SO4, filtered and concentrated. The residue was purified by Prep-TLC (PE/EA = 1/1) to give 2-[ I -(2-methoxy-phenyl)-5-thiophen-2-yl- I H-imidazol-2-ylsu lfanylmethyl]-7-methyl- pyrido[1,2-a]pyrimidin-4-one (20 mg, yield: 25%) as a yellow solid. [0401] ?HNMR (300 MHz, DMSO-d6): = 8.77 (s, 1H), 7.85 (dd, J= 9.0 Hz, 1.8 Hz,IH), 7.61-7.48 (m, 2H), 7.39 (s, lH), 7.36 (dd, J 8.0 Hz, 1.1 Hz, 1H), 7.27-7.16 (in, 2H),7.00 (t, 1=7.5 Hz, lH), 6.92 (dd, J 5.0 Hz, 3.8 Hz, lH), 6.80 (dd, J 5.0 Hz, 1.1 Hz, IH),6.34 (s, IH), 4.21 (s, 2H), 3.66 (s, 3H), 2.39 (s, 3H). MS: m/z 461.1 ( M+H).

According to the analysis of related databases, 87591-84-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE; PINKERTON, Anthony, B.; SMITH, Layton, H.; (113 pag.)WO2015/184011; (2015); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia