Category: 87789-35-3

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 87789-35-3, name is 5,7-Dichloro-2-(methylthio)thiazolo[4,5-d]pyrimidine. A new synthetic method of this compound is introduced below., COA of Formula: C6H3Cl2N3S2

The crude brown solid was slurried in methanol and morpholine (6eq) was added. The solution was stirred at room temperature for 30 min, solvent was removed under vacuum and ethyl acetate was added. The organic was washed with saturated sodium bicarbonate solution. Both the precipitate and the organic layers contained product and were subjected to silica gel chromatography to yield 5-chloro-2-(methylthio)-7-morpholinothiazolo[4,5-d]pyrimidine 78 and 5-chloro-2,7-dimorpholinothiazolo[4,5-d]pyrimidine 79.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 87789-35-3, 5,7-Dichloro-2-(methylthio)thiazolo[4,5-d]pyrimidine.

Reference:
Patent; GENENTECH, INC.; F. HOFFMANN – LA ROCHE AG; WO2009/42607; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 87789-35-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 87789-35-3, name is 5,7-Dichloro-2-(methylthio)thiazolo[4,5-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

Synthesis of ethyl 5-chloro-2-(methylthio)thiazolo[4,5-d]pyrimidine-7-carboxylate: The title compound was prepared from 5,7-dichloro-2-(methylthio)thiazolo[4,5-d]pyrimidine (commercially obtained from Combi-Block, San Diego, CA) using chemistry similar to that described in Example 1. ESI MS: m/z [M+H+] for C9H8ClN3O2S2, calcd 290.0, found 290.1.

According to the analysis of related databases, 87789-35-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Corvus Pharmaceuticals, Inc.; LI, Zhihong; FILONOVA, Lubov, Konstantinovna; VERNER, Erik; (375 pag.)EP3616753; (2020); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia