Adding a certain compound to certain chemical reactions, such as: 881-07-2, name is 2-Methyl-8-nitroquinoline, belongs to quinolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 881-07-2, SDS of cas: 881-07-2
Example 7 Synthesis of 2-methyl-8-aminoquinoleine (Compound Y) Ziessel, R.; Weibel, N.; Charbonniere, L. S. Synthesis 2006, 18, 3128-3133 2.110 g of 8-nitroquinaldine (11.19 mmol) are dissolved in 34 mL HI (57% aq). The reaction mixture is heated to 90 C. for 2 h. At ambient temperature, the reaction medium is neutralized with 150 mL of a NaHCO3 saturated aqueous solution. The aqueous phase is extracted with AcOEt (3*50 mL). The combined organic phases are washed with a Na2S2O3 saturated aqueous solution (2*50 mL), then with brine (2*50 ml). The organic phases are dried on MgSO4, filtered and evaporated under vacuum. The raw product is purified using a flash chromatography column on silica (eluent: CH2Cl2 100%). 1.251 g of a beige solid is obtained. Yield: 89%. deltaH (300 MHz, CD2Cl2) 2.69 (s, 3H), 4.96 (bs, 2H, NH2), 6.88 (dd, 1H, J 7.4 and 1.3 Hz), 7.09 (dd, 1H, J 8.1 and 1.3 Hz), 7.25 (m, 2H), 7.96 (d, 1H, J 8.4 Hz); RMN 13C: deltaC (75 MHz, CD2Cl2) 25.0, 109.8, 115.6, 122.2, 126.4, 127.0, 136.0, 137.8, 143.7, 156.3 ppm; IR: 3467, 3385, 3343, 2365, 3048, 2917, 1616, 1595, 1563, 1507, 1475, 1431, 1373, 1344, 1323, 1284, 1274, 1243, 1137, 1080, 1032, 828, 794, 744, 715, 692 cm-1. SM: El m/z: 158, 131, 103.
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