890094-38-9 | Pyrimidines

The origin of a common compound about 2-Chloro-N-isopropyl-5-nitropyrimidin-4-amine

The synthetic route of 890094-38-9 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 890094-38-9, 2-Chloro-N-isopropyl-5-nitropyrimidin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 890094-38-9, blongs to pyrimidines compound. Product Details of 890094-38-9

4-amino-3-methoxy-N-(4-methylpiperazin-1-yl)benzamide(5.3g) was added to a solution of Compound 2-3(4.3g) in n-butanol(150ml). The mixture was reacted at 90C for 4.5 hours, cooled to room temperature, filtered, washed and dried to obtain a yellow solid(6.8g) in a yield of 77.1%. 1H NMR(400 MHz, DMSO-d6): delta 9.13(s, 1H), 8.38(d, J=6.8Hz, 1H), 7.93(m, 1H), 7.63(d, J=8.0Hz, 1H), 7.46(m, 1H), 7.08(m, 1H), 7.01(m, 1H), 4.31(m, 1H), 3.86(s, 3H), 3.55(br,4H), 2.52(br, 4H), 2.32(s, 3H), 1.24(d, J=6.4Hz, 6H)ppm.

The synthetic route of 890094-38-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Si Chuan University; CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; YANG, Shengyong; WEI, Yuquan; EP2578584; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 890094-38-9

The synthetic route of 890094-38-9 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 890094-38-9, name is 2-Chloro-N-isopropyl-5-nitropyrimidin-4-amine, the common compound, a new synthetic route is introduced below. COA of Formula: C7H9ClN4O2

4-(3-(4-methylpiperazin-1-yl)propylamino)phenylamine(4.9g) was added to a solution of Compound 2-3(4.3g) in n-butanol(150ml). The mixture was reacted at 90C for 4 hours, cooled to room temperature, filtered, washed and dried to obtain a red solid(6.8g) in a yield of 79.9%. MS m/z(ESI):429[M+H]+.

The synthetic route of 890094-38-9 has been constantly updated, and we look forward to future research findings.

New learning discoveries about 890094-38-9

The synthetic route of 890094-38-9 has been constantly updated, and we look forward to future research findings.

4-amino-3-fluoro-N-(4-methylpiperazin-1-yl)benzamide(5.0g) was added to a solution of Compound 2-3(4.3g) in n-butanol(150ml). The mixture was reacted at 90C for 4 hours, cooled to room temperature, filtered, washed and dried to obtain a yellow solid(6.5g) in a yield of 75.7%. 1H NMR(400 MHz, DMSO-d6): delta 10.11(s, 1H), 9.47(s, 1H), 8.99(s, 1H), 8.38(d, J=7.6Hz, 1H), 7.86(m, 1H), 7.65(m, 2H), 4.27(m, 1H), 2.89(t, J=4.8Hz, 4H), 2.42(br, 4H), 2.19(s, 3H), 1.23(d, J=6.4Hz, 6H)ppm.

The synthetic route of 890094-38-9 has been constantly updated, and we look forward to future research findings.

Share a compound : 2-Chloro-N-isopropyl-5-nitropyrimidin-4-amine

The synthetic route of 890094-38-9 has been constantly updated, and we look forward to future research findings.

Related Products of 890094-38-9 , The common heterocyclic compound, 890094-38-9, name is 2-Chloro-N-isopropyl-5-nitropyrimidin-4-amine, molecular formula is C7H9ClN4O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: The reaction of 2,4-dichloro-5-nitropyrimidine withisopropylamine produced intermediate 2-chloro-N-isopropyl-5-nitropyrimidin-4-amine. 4-Fluoronitrobenzene reacted with1-methylpiperazine in DMSO yielded the intermediate 1-methyl-4-(4-nitrophenyl)piperazine in the presence of K2CO3. The catalytichydrogenation of 1-methyl-4-(4-nitrophenyl)piperazine with palladiumon carbon (Pd/C, 5%) quantificationally provided thedesired 4-(4-methylpiperazin-1-yl) aniline. Refluxing of the 2-chloro-N-isopropyl-5-nitropyrimidin-4-amine with 4-(4-methylpiperazin-1-yl)aniline in n-butanol yielded N4-isopropyl-N2-(4-(4-methylpiperazin-1-yl)phenyl)-5-nitropyrimidine-2,4-diamine,which was reduced to intermediate A1 with a good yield by catalytichydrogenation using Pd/C as a catalyst. Intermediates A wereprepared as these steps and used for the next step without furtherpurification. These processes were carried out as reported

The synthetic route of 890094-38-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Hei, Yuan-Yuan; Shen, Ying; Wang, Jin; Zhang, Hao; Zhao, Hong-Yi; Xin, Minhang; Cao, Yong-Xiao; Li, Yan; Zhang, San-Qi; Bioorganic and Medicinal Chemistry; vol. 26; 8; (2018); p. 2173 – 2185;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The important role of 890094-38-9

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 890094-38-9, 2-Chloro-N-isopropyl-5-nitropyrimidin-4-amine.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 890094-38-9, name is 2-Chloro-N-isopropyl-5-nitropyrimidin-4-amine. A new synthetic method of this compound is introduced below., HPLC of Formula: C7H9ClN4O2

4-amino-3-fluoro-N-(4-methylpiperidin-1-yl)benzamide(5.0g) was added to a solution of Compound 2-3(4.3g) in n-butanol(150ml). The mixture was reacted at 90C for 4.0 hours, cooled to room temperature, filtered, washed and dried to obtain a yellow solid(6.3g) in a yield of 72.8%. MS m/z(ESI): 432[M+H]+.

A new synthetic route of 2-Chloro-N-isopropyl-5-nitropyrimidin-4-amine

Statistics shows that 890094-38-9 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-N-isopropyl-5-nitropyrimidin-4-amine.

Reference of 890094-38-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.890094-38-9, name is 2-Chloro-N-isopropyl-5-nitropyrimidin-4-amine, molecular formula is C7H9ClN4O2, molecular weight is 216.63, as common compound, the synthetic route is as follows.

4-morpholinophenylamine(3.6g) was added to a solution of Compound 2-3(4.3g) in n-butanol(150ml). The mixture was reacted at 90C for 4 hours, cooled to room temperature, filtered, washed and dried to obtain a red solid(5.3g) in a yield of 74.7%. MS m/z(ESI): 359[M+H]+.

Statistics shows that 890094-38-9 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-N-isopropyl-5-nitropyrimidin-4-amine.

Extended knowledge of 890094-38-9

The synthetic route of 890094-38-9 has been constantly updated, and we look forward to future research findings.

4-amino-N-(4-methylpiperidin-1-yl)benzamide(4.6g) was added to a solution of Compound 2-3(4.3g) in n-butanol(150ml). The mixture was reacted at 90C for 4.5 hours, cooled to room temperature, filtered, washed and dried to obtain a yellow solid(5.7g) in a yield of 70.0%. 1H NMR(400 MHz, DMSO-d6): delta 10.58(s, 1H), 9.02(s, 1H), 8.48(d, J=5.6Hz, 1H), 8.20(d, J=6.8Hz, 1H), 7.86(m, 4H), 4.45(m, 1H), 3.80(m,1H), 2.94(br, 4H), 2.32(s, 3H), 1.62-1.83(m, 4H), 1.33(d, J=6.4Hz, 6H)ppm.

The synthetic route of 890094-38-9 has been constantly updated, and we look forward to future research findings.

Analyzing the synthesis route of 2-Chloro-N-isopropyl-5-nitropyrimidin-4-amine

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,890094-38-9, its application will become more common.

Electric Literature of 890094-38-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 890094-38-9 as follows.

N-(3-aminophenyl)acrylamide(3.2g) was added to a solution of Compound 2-3(4.3g) in n-butanol(150ml). The mixture was reacted at 90C for 3 hours, cooled to room temperature, filtered, washed and dried to obtain a red solid(6.0g) in a yield of 88.3%. MS m/z(ESI): 344[M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,890094-38-9, its application will become more common.

Sources of common compounds: 2-Chloro-N-isopropyl-5-nitropyrimidin-4-amine

According to the analysis of related databases, 890094-38-9, the application of this compound in the production field has become more and more popular.

Related Products of 890094-38-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 890094-38-9, name is 2-Chloro-N-isopropyl-5-nitropyrimidin-4-amine. This compound has unique chemical properties. The synthetic route is as follows.

4-amino-N-(4-methylpiperazin-1-yl)benzamide(4.7g) was added to a solution of Compound 2-3(4.3g) in n-butanol(150ml). The mixture was reacted at 90C for 3.5 hours, cooled to room temperature, filtered, washed and dried to obtain a yellow solid(5.9g) in a yield of 71.2%. 1H NMR(400 MHz, DMSO-d6): delta 10.01(s, 1H), 9.32(s, 1H), 8.78(s, 1H), 8.21(m, 2H), 7.84(s, 1H), 7.63(m, 2H), 4.31(m, 1H), 2.75(t, J=4.8Hz, 4H), 2.38(br, 4H), 2.13(s, 3H), 1.19(d, J=6.8Hz, 6H)ppm.

According to the analysis of related databases, 890094-38-9, the application of this compound in the production field has become more and more popular.

Application of 890094-38-9

At the same time, in my other blogs, there are other synthetic methods of this type of compound,890094-38-9, 2-Chloro-N-isopropyl-5-nitropyrimidin-4-amine, and friends who are interested can also refer to it.

Reference of 890094-38-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 890094-38-9, name is 2-Chloro-N-isopropyl-5-nitropyrimidin-4-amine. A new synthetic method of this compound is introduced below.

Step 2(3a) (4a)Compound (3a) (90.9 g, 0.420 mol), tetrahydrofuran (840 mL, abs.), Pt/C 5% (9.0 g, 42 mmol) and vanadyl acetylacetonate (4.5 g, 16 mmol) are added in a Parr apparatus and shaken under a hydrogen pressure of 50 psi at 20 C to 40 C for several hours until the reduction of the nitro group is complete (TLC control: silica gel, CH : EE = 1 : 1 ). The catalyst is removed and the solvent is evaporated under reduced pressure. The crude product is dissolved in a mixture of tetrahydrofuran (100 mL) and isopropanol (120 mL) and transferred into a three necked flask. Trimethylchlorosilane (54 ml) is added dropwise and the hydrochlorid precipitates. The suspension is stirred for 16 hours. The precipitate is suction filtered and dried. Yield: 54.8 g (59 % of theory) of compound (4a) as brown crystalline solid.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; LINZ, Guenter; BISCHOFF, Daniel; EBNER, Thomas; WO2011/101369; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia