Category: 89284-85-5

Electric Literature of 89284-85-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 89284-85-5, name is Methyl 2,5,6-trichloropyrimidine-4-carboxylate, molecular formula is C6H3Cl3N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 1-((R)-2-amino-propoxy)-3-chloro-propan-2-ol hydrochlorideand 3-((R)-2-amino-propoxy)-2-chloro-propan-1 -ol hydrochloride (10,65 g;52,157 mmol; 100,00 mol%) in 2-propanol (1 56,48 ml; 2046,654 mmol;3924,00 mol%) was added N-ethyldiisopropylamine (26,61 ml; 156,472 mmol;300,00 mol%) and stirred for 5 minutes. 2,5,6-Trichloro-pyrimidine-4-carboxylicacid methyl ester (12,59 g; 52,157 mmol; 100,00 mol%) was added and the reaction mixture was stirred at RT for 14 h. To the reaction mixture was addeddichloromethane and 1 N HCI. The aqueous layer was extracted withdichloromethane. The combined organic layers were dried over sodium sulfate, the solvent removed under vacuo and the residue purified by coloumn chromatography (petroleum benzene I ethyl acetate) to afford the product as as yellow oil (1 0.8g, 52 %); LCMS (method C): 1 .52 mm (purity 94.1%); [MH+] 372.00 mlz.

According to the analysis of related databases, 89284-85-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK PATENT GMBH; BURGDORF, Lars; DORSCH, Dieter; TSAKLAKIDIS, Christos; (189 pag.)WO2017/202748; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 89284-85-5, name is Methyl 2,5,6-trichloropyrimidine-4-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 89284-85-5

Aqueous ammonia (30% solution; 8.0 ml, 0.42 mol) was added dropwise to a stirred solution of 6-methoxycarbonyl-2,4,5-trichloropyrimidine (20.0 g, 0.083 mol) in THF (1000 ml) at 0 0C. The reaction mixture was stirred at 0 C for 1 hour and then filtered. The filtrate was evaporated under reduced pressure to give a white solid that was washed with twice with hexane and dried under vacuum to provide 4-amino-2,5- dichloro-6-methoxycarbonylpyrimidine (15.0 g, 82 %). 1H nmr (400 MHz, d6-DMSO) deltaH 8.57 (1H, br s), 7.94 (1H, br s), 3.88 (3H, s) ppm.

With the rapid development of chemical substances, we look forward to future research findings about 89284-85-5.

Reference:
Patent; SYNGENTA LIMITED; SYNGENTA PARTICIPATIONS AG; WHITTINGHAM, William, Guy; WINN, Caroline, Louise; GLITHRO, Harry; BOUSSEMGHOUNE, Mohamed, Abdelouahab; ASPINALL, Mary, Bernadette; WO2010/92339; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 89284-85-5 , The common heterocyclic compound, 89284-85-5, name is Methyl 2,5,6-trichloropyrimidine-4-carboxylate, molecular formula is C6H3Cl3N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of I (1.5 g, 6.2 mmol) and (rac) 3-hydroxymethylmorpholine (875 mg, 7.4 mmol) with DIPEA ( 1.6 ml_, 9.3 mmol) in EtOH (30 mL) was heated at 75C for 1 h 30 min. The mixture was cooled down to rt and solvents were removed in vacuo. The oily residue was redisolved in DCM (20 mL), washed with sat. solution of NaHC03 (3 x 20 mL), brine (30 mL), dried over Na2S04 and concentrated in vacuo. Required product, intermediate II (1.860 g, 93%) was used further without additional purifications.

The synthetic route of 89284-85-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III; PASTOR FERNANDEZ, Joaquin; FERNANDEZ-CAPETILLO RUIZ, Oscar; MARTINEZ GONZALEZ, Sonia; BLANCO APARICIO, Carmen; RICO FERREIRA, Maria del Rosario; TOLEDO LAZARO, Luis Ignacio; RODRIGUEZ ARISTEGUI, Sonsoles; MURGA COSTA, Matilde; VARELA BUSTO, Carmen; LOPEZ CONTRERAS, Andres Joaquin; RENNER, Oliver; NIETO SOLER, Maria; CEBRIAN MUNOZ, David Alvaro; WO2014/140644; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 89284-85-5 , The common heterocyclic compound, 89284-85-5, name is Methyl 2,5,6-trichloropyrimidine-4-carboxylate, molecular formula is C6H3Cl3N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of I (1.5 g, 6.2 mmol) and (rac) 3-hydroxymethylmorpholine (875 mg, 7.4 mmol) with DIPEA ( 1.6 ml_, 9.3 mmol) in EtOH (30 mL) was heated at 75C for 1 h 30 min. The mixture was cooled down to rt and solvents were removed in vacuo. The oily residue was redisolved in DCM (20 mL), washed with sat. solution of NaHC03 (3 x 20 mL), brine (30 mL), dried over Na2S04 and concentrated in vacuo. Required product, intermediate II (1.860 g, 93%) was used further without additional purifications.

The synthetic route of 89284-85-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III; PASTOR FERNANDEZ, Joaquin; FERNANDEZ-CAPETILLO RUIZ, Oscar; MARTINEZ GONZALEZ, Sonia; BLANCO APARICIO, Carmen; RICO FERREIRA, Maria del Rosario; TOLEDO LAZARO, Luis Ignacio; RODRIGUEZ ARISTEGUI, Sonsoles; MURGA COSTA, Matilde; VARELA BUSTO, Carmen; LOPEZ CONTRERAS, Andres Joaquin; RENNER, Oliver; NIETO SOLER, Maria; CEBRIAN MUNOZ, David Alvaro; WO2014/140644; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 89284-85-5, Adding some certain compound to certain chemical reactions, such as: 89284-85-5, name is Methyl 2,5,6-trichloropyrimidine-4-carboxylate,molecular formula is C6H3Cl3N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 89284-85-5.

Furfurylamine (0.155 g, 1.60 mmol) was added to a stirred solution of 6- methoxycarbonyl-2,4,5-trichloropyrimidine (prepared as described in example 4) (0.193 g, 0.80 mmol) and triethylamine (0.24 ml, 1.7 mmol) in dichloromethane (3 ml). The solution was stirred at ambient temperature for 18 hours, and then added to a mixture of ethyl acetate and brine. The organic phase was dried over magnesium sulphate, filtered and evaporated under reduced pressure to give an orange solid. This was purified by column chromatography on silica using ethyl acetate:hexane (1 :2) as eluent to provide 2,5-dichloro-4-(furan-2-ylmethylamino)-6-methoxycarbonylpyrimidine as a pale yellow solid (0.195 g, 81 %). Characterising data for this compound are as follows: m.p. 110- 112 0C; 1H nmr (400 MHz, CDCI3) deltaH 7.40 (1H, m), 6.35 (2H, m), 6.16 (1H, br s), 4.72 (2H, d), 3.98 (3H, s) ppm.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 89284-85-5, Methyl 2,5,6-trichloropyrimidine-4-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SYNGENTA LIMITED; WO2009/81112; (2009); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 89284-85-5 , The common heterocyclic compound, 89284-85-5, name is Methyl 2,5,6-trichloropyrimidine-4-carboxylate, molecular formula is C6H3Cl3N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Furfurylamine (0.155 g, 1.60 mmol) was added to a stirred solution of 6- methoxycarbonyl-2,4,5-trichloropyrimidine (prepared as described in example 1) (0.193 g, 0.80 mmol) and triethylamine (0.24 ml, 1.7 mmol) in dichloromethane (3 ml). The solution was stirred at ambient temperature for 18 hours, and then added to a mixture of ethyl acetate and brine. The organic phase was dried over magnesium sulphate, filtered and evaporated under reduced pressure to give an orange solid. This was purified by column chromatography on silica using ethyl acetate: hexane (1 :2) as eluent to provide 2,5-dichloro-4-(furan-2-ylmethylamino)-6-methoxycarbonylpyrimidine as a pale yellow solid (0.195 g, 81 %). M.p. 110-112 0C; 1H nmr (400 MHz, CDCI3) deltaH 7.40 (1 H, m), 6.35 (2H, m), 6.16 (1 H1 br s), 4.72 (2H, d), 3.98 (3H, s) ppm.

The synthetic route of 89284-85-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SYNGENTA LIMITED; WHITTINGHAM, William Guy; WINN, Caroline Louise; GLITHRO, Harry; ASPINALL, Mary Bernadette; SCREPANTI, Claudio; WO2010/125332; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia