Category: 893755-98-1

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 893755-98-1, name is 1-(Pyrimidin-2-yl)piperidin-4-ol, molecular formula is C9H13N3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 1-(Pyrimidin-2-yl)piperidin-4-ol

Step 2: 1-(1,4,5,6-Tetrahydro-2-pyrimidinyl)-4-piperidinol (181) Compound 180 (300 mg, 1.67 mmol) was combined with 10% palladium on carbon(Degussa type) (100 mg, cat.) and concentrated hydrochloric acid (500 mul_) into 10 ml. of acetic acid. The mixture was subjected to hydrogenation for 18 h at room temperature. The reaction mixture was then filtered and the solvent was removed under reduced pressure to give 304 mg (84%) of the desired compound lambdaZlambda_. 1H NMR (400 MHz, DMSOd6): delta 8.25 (m, 2 H), 4.03 – 3.41 (m, 3 H), 2.95 – 2.86 (m, 4 H), 2.09 – 1.55 (m, 6 H), 1.55 – 1.18 (m, 2 H).

With the rapid development of chemical substances, we look forward to future research findings about 893755-98-1.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/8895; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 893755-98-1, name is 1-(Pyrimidin-2-yl)piperidin-4-ol. This compound has unique chemical properties. The synthetic route is as follows. name: 1-(Pyrimidin-2-yl)piperidin-4-ol

EXAMPLE 89: Preparation of (2R,3R)-2-(2,4-difluorophenyl)-3-((1-(pyrimidin-2-yl)piperidin-4-yl)oxy)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol To a solution of 1-(pyrimidin-2-yl)piperidin-4-ol (19.4 mg, 0.08 mmol) in N,N-dimethylformamide (0.5 mL) was added potassium tert-butoxide (10.7 mg, 0.01 mmol), followed by stirring at room temperature for 2 hrs. The resulting solution was mixed with 1-(((2R,3R)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)methyl)-1H-1,2,4-triazole (20.0 mg, 0.08 mmol) and anhydrous calcium carbonate (13.2 mg, 0.01 mmol) and stirred at room temperature for one hr. The resulting reaction mixture was diluted with ethyl acetate, and washed with a saturated aqueous ammonium chloride solution and then with saline to separate an organic solvent layer. The organic solvent layer was dried over anhydrous magnesium sulfate and concentrated by evaporation at reduced pressure. The concentrate was purified using silica gel chromatography to afford the title compound (yield 21 %).1H-NMR(CDCl3, 300 MHz) delta 8.30(d, 1H, J=1.4Hz), 8.28(d, 1H, J=2.6Hz), 7.87(s, 1H), 7.62(s, 1H), 7.37(d, 1H, J=1.2Hz), 7.22-7.13(m, 1H), 6.99-6.86(m, 2H), 5.38(s, 1H), 4.45-4.28(m, 2H), 3.99-3.91(m, 1H), 3.35-3.26(m, 2H), 2.00-1.92(m, 2H), 1.59-1.47(m, 2H), 1.33-1.31(dd, 3H, J=3.1Hz, J=3.4Hz).

With the rapid development of chemical substances, we look forward to future research findings about 893755-98-1.

Reference:
Patent; DAEWOONG PHARMACEUTICAL CO., LTD.; PARK, Joon Seok; YU, Kyung A; YOON, Yun Soo; HAN, Mi Ryeong; KIM, Ji Duck; WO2011/99804; (2011); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia