Category: 89392-03-0

Related Products of 89392-03-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 89392-03-0, name is Phenyl (4,6-dimethoxypyrimidin-2-yl)carbamate, molecular formula is C13H13N3O4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

5-Amino-2-dimethylaminocarbonyl-N-[(4,6-dimethoxypyrimidin-2-yl)-aminocarbonyl]benzenesulfonamide 0.6 ml of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) is added with stirring at 0 C. to a suspension of 1.0 g of 5-amino-2-dimethylaminocarbonylbenzene-sulfonamide and 1.1 g of 4,6-dimethoxy-2-(phenoxycarbonylamino)-pyrimidine in 10 ml of acetonitrile. The mixture is stirred again until complete reaction has taken place. Following the distillative removal of the volatile components, the residue is taken up in a little water and washed with diethyl ether. The aqueous phase is subsequently acidified with concentrated hydrochloric acid (pH=2-3). The deposited solid is washed with diisopropyl ether and then dried, to give 1.4 g of a solid which comprises the two compounds 5-amino-2-dimethylaminocarbonyl-N-[(4,6-dimethoxypyrimidin-2-yl)-aminocarbonyl]-benzenesulfonamide and 5-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonylamino]-2-dimethylaminocarbonyl-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]benzenesulfonamide in a ratio of about 2:1.

According to the analysis of related databases, 89392-03-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Hoechst Schering AgrEvo GmbH; US6500952; (2002); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 89392-03-0 ,Some common heterocyclic compound, 89392-03-0, molecular formula is C13H13N3O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

l) N-[(4,6-dimethoxypyrimidin-2-yl)-aminocarbonyl]-2-dimethyl-aminocarbonyl-5-methoxycarbonylamino-benzenesulfonamide (cf. Example 53 from Table 1) DBU is added to a suspension of 1.40 g of 2-dimethylaminocarbonyl-5-methoxycarbonylamino-benzenesulfonamide (Example i) and 1.28 g of 4,6-dimethoxy-2-phenoxycarbonylamino-pyrimidine in 30 ml CH3 CN at 0 C. The reaction temperature is then allowed to rise slowly to room temperature. After the solvent has been distilled off, the residue is taken up in water and the mixture is washed with diethyl ether. After the aqueous phase has been acidified with concentrated hydrochloric acid, the sulfonyl urea which has separated out is washed with methanol and diisopropyl ether and then dried. Yield: 1.45 g as a colorless solid of m.p. 181-182 C. (decomposition).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,89392-03-0, its application will become more common.

Reference:
Patent; Hoechst Schering AgrEvo GmbH; US5922646; (1999); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 89392-03-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.89392-03-0, name is Phenyl (4,6-dimethoxypyrimidin-2-yl)carbamate, molecular formula is C13H13N3O4, molecular weight is 275.26, as common compound, the synthetic route is as follows.

As shown in the above reaction scheme, 6-ethyl-2-methylimidazo[1,2-b]pyridazin-3-sulfonamide (0.60 g, 2.50 mmol) and phenyl N-(4,6-dimethoxypyrimidin-2-yl)carbamate (0.76 g, 2.76 mmol) were suspended in acetonitrile (10 ml) and stirred under ice-cooling, during which DBU (0.46 g, 3.02 mmol) was added thereto. The temperature of the reaction solution was increased to room temperature, and the mixture was stirred at the same temperature for 4 hours. The reaction solution was poured into ice-water (150 ml) and adjusted to pH 3 with conc. hydrochloric acid. The reaction mixture was stirred at room temperature for 5 minutes, and the precipitated crystals were washed with water, acetonitrile and diethyl ether in this order, and collected by filtration. The crystals were dried under reduced pressure to give the title compound as colorless crystals. The yield was 0.55 g (52%), and the melting point was 172 to 174C.1H NMR(DMSO-d6, deltappm):1.02(3H, t, J=7.5Hz), 2.64(3H, s), 2.69(2H, q, J=7.5Hz), 3.97(6H, s), 6.03(1H, s), 7.44(1H, d, J=9.4Hz), 8.15(1H, d, J=9.4Hz), 10.56(1H, s), 13.21(1H, brs).

The chemical industry reduces the impact on the environment during synthesis 89392-03-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Sumitomo Chemical Takeda Agro Company, Limited; EP1466527; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia