Category: 89487-99-0

Synthetic Route of 89487-99-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.89487-99-0, name is 4-Hydroxy-2-(methylthio)pyrimidine-5-carbonitrile, molecular formula is C6H5N3OS, molecular weight is 167.19, as common compound, the synthetic route is as follows.

4-Hydroxy-2-(methylthio) pyrimidine-5-carbonitrile (3 mmol) and m-anisidine (3 mmol) in pentan-1-ol was refluxed for 40 h under nitrogen. The reaction mixture was concentrated in vacuo. The residue was washed with water and dried to afford 4-hydroxy-2-(3-methoxyphenylamino)pyrimidine-5-carbonitrile.

Statistics shows that 89487-99-0 is playing an increasingly important role. we look forward to future research findings about 4-Hydroxy-2-(methylthio)pyrimidine-5-carbonitrile.

Reference:
Patent; Hutchison MediPharma Enterprises Limeted; US2008/255172; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 89487-99-0, name is 4-Hydroxy-2-(methylthio)pyrimidine-5-carbonitrile. A new synthetic method of this compound is introduced below., Safety of 4-Hydroxy-2-(methylthio)pyrimidine-5-carbonitrile

Step 1 4-chloro-2-(methylthio)pyrimidine-5-carbonitrile A stirred solution of 4-hydroxy-2-(methylthio)pyrimidine-5-carbonitrile (British patent GB901749) (1.00 g, 5.98 mmol) in POCl3 (5 mL) was heated to reflux for 2 h. The reaction mixture was concentrated in vacuo and the residue quenched with ice (100 g). The solution was then basified to pH 8 with sat. aq NaHCO3 and extracted with ethyl acetate (3*50 mL). The combined ethyl acetate layers were washed with water (20 mL), brine (10 mL), dried over Na2SO4, filtered and concentrated to give the title compound. 1H NMR (400 MHz, CD3OD): delta8.84 (s, 1 H, Ar), 2.62 (s, 3 H, CH3)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 89487-99-0, 4-Hydroxy-2-(methylthio)pyrimidine-5-carbonitrile.

Reference:
Patent; Claiborne, Christopher F.; Butcher, John W.; Claremon, David A.; Libby, Brian E.; Liverton, Nigel J.; Munson, Peter M.; Nguyen, Kevin T.; Phillips, Brian; Thompson, Wayne; McCauley, John A.; US2002/165241; (2002); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 89487-99-0, name is 4-Hydroxy-2-(methylthio)pyrimidine-5-carbonitrile. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 4-Hydroxy-2-(methylthio)pyrimidine-5-carbonitrile

Step B: A mixture of 4-hydroxy-2-methylsulfanyl-pyrimidine-5-carbonitrile (2.76 g) and phosphorus oxychloride (15 mL) was heated at reflux, under argon atmosphere, for 3 h. The reaction mixture was cooled and then evaporated under reduced pressure. Hexane was added to the residue and the mixture was heated at reflux, the resulting mixture was decanted and the same procedure was repeated for 4 times. The combined supernatant layers were evaporated to afford 1.13 g of 4-chloro-2-methylsulfanyl-pyrimidine-5-carbonitrile as a white powder.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 89487-99-0, 4-Hydroxy-2-(methylthio)pyrimidine-5-carbonitrile.

Reference:
Patent; Roche Palo Alto LLC; US2009/270389; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 89487-99-0 , The common heterocyclic compound, 89487-99-0, name is 4-Hydroxy-2-(methylthio)pyrimidine-5-carbonitrile, molecular formula is C6H5N3OS, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a cooled solution of 4-hydroxy-2-(methylthio)pyrimidine-5-carbonitrile (8) (10.8 g, 65 mmol) in toluene (150 ml), phosphorus oxychloride (23.8 ml, 260 mmol) was slowly added. The reaction mixture was stirred at 110 C for 6 h. After evaporation of the organic solvent, the residue was cooled to room temperature and added a lot of ice water. At this time, a brown solid was formed and collected by filtration. The crude product was dried in a vacuum oven to give 4-chloro-2-(methylthio)pyrimidine -5-carbonitrile 9(6.8 g). This product was taken up for the next step without any purification. Yield: 58%; Purity: 90%; LC-MS m/z: 186.0 [M + H]+.

The synthetic route of 89487-99-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yang, Ling-Ling; Li, Guo-Bo; Yan, Heng-Xiu; Sun, Qi-Zheng; Ma, Shuang; Ji, Pan; Wang, Ze-Rong; Feng, Shan; Zou, Jun; Yang, Sheng-Yong; European Journal of Medicinal Chemistry; vol. 56; (2012); p. 30 – 38;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 89487-99-0, name is 4-Hydroxy-2-(methylthio)pyrimidine-5-carbonitrile. A new synthetic method of this compound is introduced below., name: 4-Hydroxy-2-(methylthio)pyrimidine-5-carbonitrile

Step B: A mixture of 4-hydroxy-2-methylsulfanyl-pyrimidine-5-carbonitrile (2.76 g) and phosphorus oxychloride (15 mL) was heated at reflux, under argon atmosphere, for 3 h. The reaction mixture was cooled and then evaporated under reduced pressure. Hexane was added to the residue and the mixture was heated at reflux, the resulting mixture was decanted and the same procedure was repeated for 4 times. The combined supernatant layers were evaporated to afford 1.13 g of 4-chloro-2-methylsulfanyl-pyrimidine-5-carbonitrile as a white powder.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 89487-99-0, 4-Hydroxy-2-(methylthio)pyrimidine-5-carbonitrile.

Reference:
Patent; Roche Palo Alto LLC; US2009/270389; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia