Category: 89792-07-4

Jonckers, Tim Hugo Maria et al. published their patent in 2016 |CAS: 89792-07-4

The Article related to pyrrolopyrimidine preparation influenza virus infection treatment, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.HPLC of Formula: 89792-07-4

On March 17, 2016, Jonckers, Tim Hugo Maria; Mc Gowan, David Craig; Raboisson, Pierre Jean-Marie Bernard; Embrechts, Werner Constant Johan; Guillemont, Jerome Emile Georges published a patent.HPLC of Formula: 89792-07-4 The title of the patent was Preparation of pyrrolopyrimidines for the treatment of influenza virus infection. And the patent contained the following:

Title compounds I [X = N or C (optionally substituted with -CN, -CF3, -CONH2, etc.); R1 = H or CH3; R2 = H or NH2; R3 = carboxy-substituted alkyl, carboxy-substituted cycloalkyl, -N-alkylsulfone, etc.; or stereoisomeric forms, pharmaceutically acceptable salts, solvates, or polymorphs thereof] were prepared For example, reaction of 2,4-dichloro-5-fluoropyrimidine with cis-N-(3-aminocyclohexyl)pyrrolidine-1-carboxamide/DIPEA followed by Pd(PPh3)4-catalyzed coupling reaction with 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine and deprotection using NaOMe afforded compound II. In anti-influenza activity test against A/Taiwan/1/86 (H1N1) virus, IC50 value of II was 0.005 μM. The experimental process involved the reaction of 2-Methyl-7H-pyrrolo[2,3-d]pyrimidine(cas: 89792-07-4).HPLC of Formula: 89792-07-4

The Article related to pyrrolopyrimidine preparation influenza virus infection treatment, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.HPLC of Formula: 89792-07-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Liu, Shuangwei et al. published their patent in 2017 |CAS: 89792-07-4

The Article related to pyrrolopyrimidine derivative preparation rheumatoid arthritis, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Quality Control of 2-Methyl-7H-pyrrolo[2,3-d]pyrimidine

On July 21, 2017, Liu, Shuangwei published a patent.Quality Control of 2-Methyl-7H-pyrrolo[2,3-d]pyrimidine The title of the patent was Process for preparation of pyrrolo[2,3-d]pyrimidine derivative for treating rheumatoid arthritis. And the patent contained the following:

The invention relates to preparation of pyrrolo[2,3-d]pyrimidine derivative of formula I, wherein R is Me, CF3, F, Ph for treating rheumatoid arthritis. Compound I was prepared via bromination of 2-Me-7-H-pyrrolo[2,3-d]pyrimidine followed by carboxylation, acylation, condensation and reaction with morpholine. The medicine has obvious therapeutic action to RA, and can be used for treating rheumatoid arthritis. The experimental process involved the reaction of 2-Methyl-7H-pyrrolo[2,3-d]pyrimidine(cas: 89792-07-4).Quality Control of 2-Methyl-7H-pyrrolo[2,3-d]pyrimidine

The Article related to pyrrolopyrimidine derivative preparation rheumatoid arthritis, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Quality Control of 2-Methyl-7H-pyrrolo[2,3-d]pyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Beard, Charles D. et al. published their patent in 2006 |CAS: 89792-07-4

The Article related to iodopyridinamine preparation acetylene palladium copper sonogashira coupling, ethynylpyridinamine preparation intramol cyclization, pyrrolopyridine azaindole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Related Products of 89792-07-4

On August 17, 2006, Beard, Charles D.; Lee, Ving J.; Whittle, C. Ed published a patent.Related Products of 89792-07-4 The title of the patent was Process for the preparation of aza-annelated pyrroles, thiophenes and furans as potential bioisosteres of indole, benzofuran and benzothiophene scaffolds. And the patent contained the following:

A process for the preparation of aza-annelated pyrroles, thiophenes and furans I [wherein T = (un)substituted NH, O or S; R2 = H, (halo)alkyl, (un)substituted aryl, etc.; W, X, Y, Z = (un)substituted CH or N with limitations; D = H or Br], which are potentially useful as bioisosteres of indole, benzofuran and benzothiophene scaffolds, is disclosed. The process comprises coupling iodides II with acetylene compounds CHCCH2R2 or silyl group-protected acetylene such as CHC-TMS, and cyclizing the resultant alkynes in protic solvents. Key features of the method include regioselective substitution in the iodine sites and tolerance of a wide range of sensitive functional groups. For instance, regioselective Sonogashira reaction of 5-bromo-3-iodo-2-pyridinamine (preparation given) with CHC-TMS in toluene in the presence of PdCl2(PPh3)2, CuI and Et3N gave ethynylpyridinamine III in 80% yield. This compound underwent t-BuOK-mediated intramol. cyclization in refluxing t-butanol to afford 5-bromo-1H-pyrrolo[2,3-b]pyridine in 60% yield. The experimental process involved the reaction of 2-Methyl-7H-pyrrolo[2,3-d]pyrimidine(cas: 89792-07-4).Related Products of 89792-07-4

The Article related to iodopyridinamine preparation acetylene palladium copper sonogashira coupling, ethynylpyridinamine preparation intramol cyclization, pyrrolopyridine azaindole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Related Products of 89792-07-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Folmer, Rutger et al. published their patent in 2021 |CAS: 89792-07-4

The Article related to azaindole preparation dyrk1b inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.HPLC of Formula: 89792-07-4

On April 8, 2021, Folmer, Rutger; Hekking, Koen F. W.; Calpe, Blaise; Mueller, Gerhard; Fabritius, Charles-Henry published a patent.HPLC of Formula: 89792-07-4 The title of the patent was Azaindole derivatives and related compounds as inhibitors of dual specificity tyrosine phosphorylation regulated kinase 1B and their preparation. And the patent contained the following:

The invention relates to compounds of formula I, optionally in the form of a pharmaceutically acceptable salt, solvate, cocrystal, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, in particular for use in the treatment, amelioration or prevention of cancer, Alzheimer, Parkinson, Down syndrome, metabolic syndrome, diabetes and/or osteoarthritis. Compounds of formula I wherein X1 is N, CH and CF; X2 = N, CH and CR1; each R2 is independently H and R1; Y1 is S and O; Y2 is C, CN, CMe, CCl and CF; Y3 is N, CH and CR1; A is (un)substituted (mono/bi/tri)cyclic heterocyclyl; R1 is (un)substituted C1-6 alkyl, halo, CN, NO2, etc.; and pharmaceutically acceptable salts, solvates, cocrystals, tautomers, racemates, enantiomers, diastereomers and mixtures thereof, are claimed. Example compound II was prepared by cyclization of 2-chloro-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethan-1-one with 1H-imidazole-4-carbothioamide. The invention compounds were evaluated for their DYRK1B inhibitory activity. From the assay it was determined that compound II exhibited IC50 value in the range of 10 nM to < 100 nM. The experimental process involved the reaction of 2-Methyl-7H-pyrrolo[2,3-d]pyrimidine(cas: 89792-07-4).HPLC of Formula: 89792-07-4

The Article related to azaindole preparation dyrk1b inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.HPLC of Formula: 89792-07-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Analyzing the synthesis route of 89792-07-4

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 89792-07-4, 2-Methyl-7H-pyrrolo[2,3-d]pyrimidine.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 89792-07-4, name is 2-Methyl-7H-pyrrolo[2,3-d]pyrimidine. A new synthetic method of this compound is introduced below., category: pyrimidines

2-methyl-7H-pyrrolo[2,3-d]pyrimidine (426 mg, 3.2 mmol) was dissolved in DMF (54 mL) cooled in an ice bath and treated with N-bromosuccinimide (569 mg, 3.2 mmol) portionwise under nitrogen. The resulting mixture was stirred for 20 minutes, allowed to warm to room temperature and stirred for 10 minutes. The reaction was quenched by the addition of CH3OH (5 mL) and the solvent removed under reduced pressure. The residue was purified by silica flash column chromatography using a heptane to ethyl acetate gradient. The desired fractions were collected and the solvent was removed under reduced pressure to afford 5-bromo-2-methyl-7H-pyrrolo[2,3-d]pyrimidine, 19.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 89792-07-4, 2-Methyl-7H-pyrrolo[2,3-d]pyrimidine.

Reference:
Patent; Janssen Sciences Ireland UC; JONCKERS, Tim Hugo Maria; MC GOWAN, David Craig; RABOISSON, Pierre Jean-Marie Bernard; EMBRECHTS, Werner Constant Johan; GUILLEMONT, Jerome Emile Georges; (42 pag.)US2017/253600; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Some scientific research about 2-Methyl-7H-pyrrolo[2,3-d]pyrimidine

According to the analysis of related databases, 89792-07-4, the application of this compound in the production field has become more and more popular.

Synthetic Route of 89792-07-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 89792-07-4, name is 2-Methyl-7H-pyrrolo[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

An equal volume of dichloromethane (50 ml) and tetrahydrofuran (50 ml) were mixed,The compound 2-methyl-7H- [2,3-d] pyrrolopyrimidine (10 mmol) was added to the system,After stirring for 20 minutes,System cooling to 0-5 ,JoinTribromopyridinium(20 mmol),The system continues at 0-5 CStirring for 1 hour,The reaction mixture was slowly added to an aqueous solution of saturated sodium carbonate. The system was stirred at 20 C overnight and under reduced pressure Filtered, washed with water, dried at 55 C,To give 1.8 g of a yellow solid 4-bromo-2-methyl-7H- [2,3-d] pyrrolopyrimidine in 85% yield.

According to the analysis of related databases, 89792-07-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Liu Shuangwei; (11 pag.)CN106967073; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Analyzing the synthesis route of 89792-07-4

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 89792-07-4, 2-Methyl-7H-pyrrolo[2,3-d]pyrimidine.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 89792-07-4, name is 2-Methyl-7H-pyrrolo[2,3-d]pyrimidine. A new synthetic method of this compound is introduced below., Formula: C7H7N3

2-methyl-7H-pyrrolo[2,3-d]pyrimidine (426 mg, 3.2 mmol) was dissolved in DMF (54 mL) cooled in an ice bath and treated with N-bromosuccinimide (569 mg, 3.2 mmol) portionwise under nitrogen. The resulting mixture was stirred for 20 minutes, allowed to warm to room temperature and stirred for 10 minutes. The reaction was quenched by the addition of CH3OH (5 mL) and the solvent removed under reduced pressure. The residue was purified by silica flash column chromatography using a heptane to ethyl acetate gradient. The desired fractions were collected and the solvent was removed under reduced pressure to afford 5-bromo-2-methyl-7H-pyrrolo[2,3-d]pyrimidine, 19.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 89792-07-4, 2-Methyl-7H-pyrrolo[2,3-d]pyrimidine.

Reference:
Patent; Janssen Sciences Ireland UC; JONCKERS, Tim Hugo Maria; MC GOWAN, David Craig; RABOISSON, Pierre Jean-Marie Bernard; EMBRECHTS, Werner Constant Johan; GUILLEMONT, Jerome Emile Georges; (42 pag.)US2017/253600; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia