Category: 90213-66-4

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 90213-66-4, name is 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. 90213-66-4

To a mixture of 2,4-dichloro-7H- pyrrolo[2,3-d]pyrimidine (7 g, 37.23 mmol) in DMF (37 mL) was added NIS (8,79 g, 39.09 mmol) in one portion at 0 C under N2. The mixture was stirred at 25 C for 1.5 h. The reaction solution was poured into ice-water ( 100 mL), and the resulting precipitate was isolated by filtration. The filter cake was washed with ice water (2 chi 50 mL) and dried under reduced pressure to give 2,4-dichloro-5-iodo-7H- pyrrolo[2,3-d]pynmidme as a yellow solid. LCMS: RT 0,771 min, m/z = 313.9 [M+H]+. NMR (400 MHz, DMSO): delta 13.12 (br. s, 1 H), 7.97 (d, J=2.01 Hz, 1 H).

Statistics shows that 90213-66-4 is playing an increasingly important role. we look forward to future research findings about 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine.

Reference:
Patent; DENALI THERAPEUTICS INC.; ESTRADA, Anthony A.; FENG, Jianwen A.; LYSSIKATOS, Joseph P.; SWEENEY, Zachary K.; DE VICENTE FIDALGO, Javier; (271 pag.)WO2017/87905; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 90213-66-4, name is 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. 90213-66-4

Intermediate 46; 2,4-Dichloro-7-methyl-7H-pyrrolor2,3-d1pyrimidine 103496-1P2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine (2370 mg, 12.61 mmol) was dissolved in acetonitrile (8320 mul) and sodium hydride (529 mg, 13.24 mmol) was added portion- wise. The reaction mixture was stirred at room temperature for 30 minutes until gas evolution ceased. Methyl iodide (867 mul, 13.87 mmol) was added and the resulting mixture was stirred for 30 minutes. The reaction mixture was then poured into water and extracted with DCM/MeOEta. Concentration of the organic layers under reduced pressure provided a residue, which was purified utilizing ISCO (0%-? 100% DCM/EtOAc) to afford the title product (2. Ig). LCMS: 204 [M+Eta]+.

Statistics shows that 90213-66-4 is playing an increasingly important role. we look forward to future research findings about 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; CHUAQUI, Claudio, Edmundo; HUANG, Shan; IOANNIDIS, Stephanos; SHI, Jie; SU, Mei; SU, Qibin; WO2010/38060; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

90213-66-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 90213-66-4, name is 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine, the common compound, a new synthetic route is introduced below.

A stirred solution of S-1 (2.00 g, 10.7 mmol) in CH2Cl2(20 mL) taken in a round- bottom flask was charged with DIPEA (3.7 mL, 21.4 mmol), DMAP (0.039 g, 0.32 mmol) and p-toluene sulfonyl chloride (2.25 g, 11.7 mmol) successively at ambient temperature under nitrogen atmosphere. The reaction mixture was stirred for 2 h at same temperature. The reaction mixture was diluted with CH2Cl2(100 mL) and was washed with water (40 mL) and HCl (1 N, 40 mL). The combined organic layer was washed with brine (1 ¡Á 50 mL), dried over anhydrous Na2SO4and was concentrated under reduced pressure. The obtained residue was washed with hexanes (2 ¡Á 50 mL) and was dried under vacuum to afford S-2 (3.50 g, 95%, AMRI lot IN-SKY-C-03) as an off-white solid. The compound was characterized by1H NMR analysis.1H NMR (400 MHz, CDCl3): delta 8.03 (d, J = 8.4 Hz, 2H), 7.68 (d, J = 4 Hz, 1H), 7.29 (d, J = 8.12 Hz, 2H), 6.60 (d, J = 4 Hz, 1H), 2.36 (s, 3H).

Statistics shows that 90213-66-4 is playing an increasingly important role. we look forward to future research findings about 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine.

Reference:
Patent; SOUTHERN RESEARCH INSTITUTE; AUGELLI-SZAFRAN, Corinne, E.; SUTO, Mark; GALEMMO, Robert; MOUKHA-CHAFIQ, Omar; GUPTA, Vandana; ANANTHAN, Subramaniam; (254 pag.)WO2017/106771; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

90213-66-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 90213-66-4, name is 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C6H3Cl2N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 2,4-dichloro-7H-pyrrolo[2,3-djpyrimidine 34 (237 mg, 1.26 mmol) in CH3CN (1 mL) was added NaH (33.3 mg, 1.39 mmol) portion- wise at 0 C. The reaction mixture was stirred at room temperature for 20 mm until gas evolution was ceased. Methyl iodide (86.4 i.il, 1.39 mmol) was added and stirred the reaction mixture for 1 h at room temperature. To the reaction mixture was added water and extracted with ethyl acetate (2 x 30 mL). The combined organic layers were dried over Mg504, and then concentrated under vacuum. The resultant crude residue was purified by silica-gel column chromatography to afford 35 (144 mg, 58%) as white solid. ?H-NMR (400 MHz, DMSO-d6) oe 7.76 (d, J = 3.6 Hz, 1H), 6.71 (d, J = 3.6 Hz, 1H), 3.81 (s, 3H); MS: (m/z) [M+Hjb 204.02.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 90213-66-4, 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY; TSANTRIZOS, Youla S.; SEBAG, Michael; (120 pag.)WO2018/137036; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 90213-66-4, 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 90213-66-4, blongs to pyrimidines compound. 90213-66-4

In a flask 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine (1.0 g, 5.3 mmol) in DMF (30 rnL) was added NaH (60% in mineral oil, 0.21 g, 5.3 mmol). After stirring 5 min at room temperature the reaction mixture was added tosyl chloride (1.0 g, 5.3 mmol) and stirred 1 h at room temperature. The reaction mixture was diluted with H2O (100 mL) and filtered. The filtered solid was washed with H2O (20 mL) and dried 5 h under house vacuum at 80 0C to afford the title compound as a yellow solid (1.6 g, 90%). 1H NMR (500 MHz, DMSO-d6): delta 2.38 (s, 3H), 6.98 (d, J = 4.1 Hz, IH), 7.50 (d, J = 8.3 Hz, 2H), 8.03 (d, J = 8.5 Hz, 2H), 8.11 (d, J = 4.1 Hz, IH) MS (ES+): m/z 343 (M+H)+

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,90213-66-4, its application will become more common.

Reference:
Patent; TARGEGEN INC.; WO2009/49028; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 90213-66-4, name is 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. 90213-66-4

A solution of 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine (1.00 g, 5.32 mmol) in THF (8 mL) was stirred at 0 C for 5 mm. Then sodium hydride (255 mg, 6.38 mmol) was added. The resulting mixture was stirred for 15 mm, then iodomethane (8.50 g, 53.20 mmol) was added. The reaction mixture was warmed to rt and stirred overnight. H20 (100 mL) was added to quench the reaction, and the resulting mixture was extracted with EtOAc (50 mL x 3). The combined organic phases were washed with brine (80 mL), dried over anhydrous Na2504, filtered, and the filtrate was concentrated in vacuo. The residue was purified by silica gel chromatograph (PE/EtOAc (v/v) = 10/1) to give the tilte compound as a white solid (1.00 g, 93 %).MS (ESI, pos. ion) m/z: 203.0 [M+H]t

Statistics shows that 90213-66-4 is playing an increasingly important role. we look forward to future research findings about 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; REN, Qingyun; TANG, Changhua; YIN, Junjun; YI, Kai; LEI, Yibo; WANG, Yejun; ZHANG, Yingjun; (215 pag.)WO2018/127096; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

90213-66-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 90213-66-4, name is 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

1.0 g of 2,4-dichloro-7H-pyrrole [2,3-d]pyrimidine was dissolved in 50 mL of dichloromethane under ice bath. To the above mixed solution, 1.06 g of p-toluenesulfonyl chloride, 1.08 g of triethylamine, and 0.019 g of 4-dimethylaminopyridine were slowly added. The mixed solution was stirred at room temperature for 5 h. After the reaction was completed, 150 mL of dichloromethane was poured into the above solution, and the organic phase was washed three times with 100 mL of each of water, aqueous citric acid and brine; The organic phase was dried over anhydrous magnesium sulfate (MgSO4). Recrystallization from petroleum ether gave 1.6 g of white pure product. The yield was 89%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 90213-66-4, 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine.

Reference:
Patent; Shandong University; Zhang Yingjie; Liang Xuewu; Xu Wenfang; (47 pag.)CN108864057; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

90213-66-4, Adding some certain compound to certain chemical reactions, such as: 90213-66-4, name is 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine,molecular formula is C6H3Cl2N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 90213-66-4.

Zinc powder (8700 ¡¤ 0g, 133piomicron1, 10 ¡¤ Oeq ?) was added portionwise to glacial acetic acid (3 ¡¤ 3L, 53 ¡¤ 2mo1.4 ¡¤ Oeq ¡¤) and acetonitrile (30 ¡¤ 0L) mixture was added to complete the reaction temperature was raised to 80 C for 14 hours, the reaction was complete by TLC.87] The reaction mixture was cooled to 25 C, suction filtration, the filtrate was concentrated under reduced pressure and added to 30L of ice water, precipitated a large number of pink solid, filtration, the filter cake washed with water (5L X 3), dried to give a white solid 1501.7g. Yield: 73.54%.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 90213-66-4.

Reference:
Patent; Nanjing Furunkaide Bio-pharmaceutical Co., Ltd.; Rong Liang; Li Jin; Li Hui; Jie Yuanping; Wu Xihan; Yang Minmin; (12 pag.)CN105949196; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 90213-66-4, name is 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C6H3Cl2N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 90213-66-4

To a mixture of 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine (1.67 g, 8.88 mmol), p- toluenesulfonyl chloride (1.72 g, 9.02 mmol) and triethylamine (2.50 mL, 18.0 mmol) in CH2C2 (15 mL), dimethylaminopyridine (30 mg, 0.24 mmol) was added. It was stirred at room temperature for 20 h. Water and CH2Ci2 were added. The organic phase was separated, washed with IN HCl, then with 5% NaHCO3, dried over Na2SO4, concentrated in vacuo to give 2,4-dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine as a solid (3.03 g).

The chemical industry reduces the impact on the environment during synthesis 90213-66-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; PORTOLA PHARMACEUTICALS, INC.; WO2009/131687; (2009); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

90213-66-4 , The common heterocyclic compound, 90213-66-4, name is 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C6H3Cl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

In the ice bath conditions,A solution of 2,4-dichloro-7H-pyrrole [2,3-d] pyrimidine 1.0 gWas dissolved in 50 mL of dichloromethane,To the above mixed solution, 1.06 g of p-toluenesulfonyl chloride was added slowly,Triethylamine 1.08 g,N, N-dimethylpyridin-4-amine, 0.019 g,The mixed solution was stirred at room temperature for 5 h,After the reaction is complete,To the above solution was poured into 150 mL, the organic phase was washed with water,Citric acid aqueous solution and brine solution were washed three times each. The organic phase was dried with anhydrous magnesium sulfate overnight, and the solvent was evaporated under reduced pressure to obtain crude product.Recrystallization from petroleum ether gave 1.6 g of pure white product.Yield 89%.

The synthetic route of 90213-66-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shandong University; Zhang, Yingjie; Xu, Wenfang; Liang, Xuewu; (18 pag.)CN106349224; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia