Category: 905856-70-4

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.905856-70-4, name is 2-Bromo-5-iodopyrimidine, molecular formula is C4H2BrIN2, molecular weight is 284.88, as common compound, the synthetic route is as follows.Quality Control of 2-Bromo-5-iodopyrimidine

5) In a 250 ml three-necked flask, 0.03 mol of intermediate 4-4 was added under nitrogen protection.0.036 mol of 2-bromo-5-iodopyrimidine, 150 ml of toluene, stirred and mixed, and then added 0.045 mol of sodium t-butoxide.0.0015 mol Pd2 (dba) 3, 0.0015 mol of tri-tert-butylphosphine, heated to 115 C with stirring.The reaction was refluxed for 24 hours, and the spot plate was sampled, indicating that no intermediate 4-4 remained, and the reaction was complete;Naturally cooled to room temperature, filtered, and the filtrate was evaporated to dryness under reduced pressure and passed through a neutral silica gel column.Intermediate 4-5 was obtained with HPLC purity of 99.3%, yield 68.9%

At the same time, in my other blogs, there are other synthetic methods of this type of compound,905856-70-4, 2-Bromo-5-iodopyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Tang Dandan; Zhang Zhaochao; Li Chong; Zhang Xiaoqing; (66 pag.)CN108203416; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 905856-70-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 905856-70-4, name is 2-Bromo-5-iodopyrimidine, molecular formula is C4H2BrIN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

2-Bromo-5-iodopyrimidine (1.2 g, 4.2 mmol) was dissolved under nitrogen in 25 ml THF. Bis- (triphenylphosphine)-palladium(II)dichloride (300 mg, 420 muiotaetaomicron, 0.1 equiv.),ethynyltrimethylsilane (540 mg, 0.77 ml, 5.48 mmol, 1.3 equiv.), triethylamine (0.85 g, 1.17 ml, 8.4 mmol, 2 equiv.) and copper(I)iodide (40 mg, 210 muiotaetaomicron, 0.05 equiv.) were added and the mixture was stirred for 4 hours at 50C. The reaction mixture was cooled and evaporated to dryness. The crude product was purified by flash chromatography on silica gel, eluting with an ethyl acetate: heptane gradient 0: 100 to 40:60. The desired 2-bromo-5-trimethylsilanylethynyl- pyrimidine (0.75 g, 70 % yield) was obtained as a yellow solid, MS: m/e = 255/257 (M+H+).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 905856-70-4, 2-Bromo-5-iodopyrimidine.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GREEN, Luke; GUBA, Wolfgang; JAESCHKE, Georg; JOLIDON, Synese; LINDEMANN, Lothar; RICCI, Antonio; RUEHER, Daniel; STADLER, Heinz; VIEIRA, Eric; WO2011/128279; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia