Category: 911461-47-7

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 911461-47-7, name is 4,6-Dichloropyrimidine-5-carboxamide. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 911461-47-7

To a solution of 4,6-dichloropyrimidine-5-carboxamide (24.6 g, 128 mmol) in methanol (200 mL) was added a solution of sodium methylate (15.2 g, 282 mmol) in MeOH (100 mL). The resulted mixture was stirred at rt for 4.5 hours and concentrated in vacuo. The residue was purified by a silica gel column chromatography (EtOAc/MeOH (v/v)=25/1) to give the title compound as a pale yellow solid (18.3 g, yield: 71.1%). [0686] MS (ESI, pos. ion) mz: 184.1 [M+H]+; [0687] 1H NMR (600 MHz, CDCl3) delta (ppm): 8.47 (s, 1H), 6.30 (br. s, 1H), 5.98 (br. s, 1H), 4.07 (s, 6H).

With the rapid development of chemical substances, we look forward to future research findings about 911461-47-7.

Reference:
Patent; CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.; Xi, Ning; Wang, Liang; Wang, Tingjin; US2015/87658; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 911461-47-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 911461-47-7, name is 4,6-Dichloropyrimidine-5-carboxamide, molecular formula is C5H3Cl2N3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of amine 21 (650 mg, 3.8 mmol), (4,6-dichloropyrimidin-5-yl)formamide (1.21 g, 5.7 mmol; prepared according to a published procedure25), and DIPEA (2.25 mL, 11.4 mmol) in BuOH (20 mL) washeated in a sealed microwave reactor for 2 h at 140 C. The solvent was removed in vacuo and the residue was purified by column chromatography [silica gel (400 g), EtOAc ? EtOAc-toluene-acetone-EtOH (17:4:3:1)] to give a foam; yield: 669 mg (57%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 911461-47-7, 4,6-Dichloropyrimidine-5-carboxamide.

Reference:
Article; ?ala, Michal; Dejmek, Milan; Prochazkova, Eli?ka; H?ebabecky, Hubert; Ryba?ek, Ji?i; Dra?insky, Martin; Novak, Pavel; Rosenbergova, ?arka; Rosenberg, Ivan; Nencka, Radim; Synthesis; vol. 47; 17; (2015); p. 2654 – 2662;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 911461-47-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 911461-47-7, name is 4,6-Dichloropyrimidine-5-carboxamide. This compound has unique chemical properties. The synthetic route is as follows.

4, 6-DICHLORO-PYRIMIDINE-5-CARBALDEHYDE (15.0 g, 84,75 mmol, 1.0 equivalent) was dissolved in ethyl acetate (150 mL), mixed with hydroxylamine hydrochloride in water (30ML) and added sodium acetate. Reaction was at left room temperature for 1.5 hours. Worked up with ethyl acetate, sodium bicarbonate, dried with magnesium sulfate, rotovaped and dried and high vacuum to afford a white solid (14.593 g). The white solid (iminohydroxy intermediate) was added to thionyl chloride (100 mL) at 0 C with stirring and allowed to warm to room temperature for 3 hours. The reaction was quenched in ice (500G), and the precipitated was filtered off, washed with cold water, and dried under high vacuum to afford a white solid as product (10. 739g, 72. 8%). 1H NMR 400MHZ CDC13 B (ppm): 8. 95 (s, LH, pyrimidine).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 911461-47-7, 4,6-Dichloropyrimidine-5-carboxamide.

Reference:
Patent; ARENA PHARMACEUTICALS, INC.; WO2005/7647; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 911461-47-7, 4,6-Dichloropyrimidine-5-carboxamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C5H3Cl2N3O, blongs to pyrimidines compound. HPLC of Formula: C5H3Cl2N3O

The compound 4,6-dichloropyrimidine-5-carboxamide (1.65 g, 8.6 mmol) was dissolved in methanol (30 mL) and then treated withSodium methoxide (1.15 g, 21.3 mmol) was added thereto, and the mixture was heated to 40 C and the reaction was stirred for 12 hours. Then, the mixedThe material was filtered, and the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (pure EtOAc) to give the title compound asWhite solid (1.30 g, 83%).

The synthetic route of 911461-47-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Wang Liang; Wu Zuping; Feng Xuejin; Wu Yanjun; (154 pag.)CN104513235; (2017); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia