Category: 916420-27-4

Reference of 916420-27-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 916420-27-4, name is tert-Butyl 2,4-dichloro-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate, molecular formula is C12H15Cl2N3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Benzyl 1-piperazinecarboxylate (1.268 mL, 6.575 mmol) and tert-Butyl 2,4-dichloro-5,6-dihydropyrido[3 4-d]pyrimidine-7(8H)-carboxylate (2 g, 6.575 mmol) were dissolved in dimethyl acetamide (10 mL) and treated with N-ethyl-N-isopropylpropan-2-amine (3.445 mL, 19.73 mmol). The reaction mixture was stirred at 85° C. for 2 hours. The reaction mixture was cooled to room temperature, diluted with ethyl acetate, washed with water and brine, dried over MgSO 4, filtered and concentrated. The concentrate was purified by chromatography (CombiFlash , 0%-50% ethyl acetate:Hexanes as the eluent to provide the product (2.69 g, 83%). ES+APCI MS m/z 488.2, 490.2 [M+H] +.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 916420-27-4, tert-Butyl 2,4-dichloro-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate.

Reference:
Patent; Mirati Therapeutics, Inc.; Array BioPharma Inc.; Blake, James F.; Burgess, Laurence E.; Chicarelli, Mark Joseph; Christensen, James Gail; Cook, Adam; Fell, Jay Bradford; Fischer, John P.; Marx, Matthew Arnold; Mejia, Macedonio J.; Savechenkov, Pavel; Vigers, Guy P.A.; Smith, Christopher Ronald; Rodriguez, Martha E.; US2019/144444; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 916420-27-4, name is tert-Butyl 2,4-dichloro-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. name: tert-Butyl 2,4-dichloro-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate

Step 1- tert-butyl 2-chloro-4-(pyridin-4-yl)-5,6-dihydropyrido[3,4-d]pyrimidine- 7(8H)-carboxylate (ij): 4-(Tributylstannyl)pyridine (247 mg, 0.671 mmol), t-butyl 2,4- dichloro-5,6-dihydropyrido-[3,4-d]pyrimidine-7(8H)-carboxylate (bx) (200 mg, 0.6 mmol) and tetrakis(triphenylphosphine)palladium(0) (76 mg, 0.066 mmol) were dissolved in 1,4- Dioxane (7 mL). The reaction was micro waved at 1300C for 20 minutes The reaction mixture was concentrated on silica gel and purified by flash chromatography (100% Hex to 80% EtOAc/Hex) to give compound ij as a white solid: LC/MS: m/z = + 347.8 (M +H)+.

With the rapid development of chemical substances, we look forward to future research findings about 916420-27-4.

Reference:
Patent; GENENTECH, INC.; BERGERON, Philippe; COHEN, Frederick; ESTRADA, Anthony; KOEHLER, Michael, F. T.; LAU, Kevin, Hon Luen; LY, Cuong; LYSSIKATOS, Joseph, P.; ORTWINE, Daniel, Fred; PEI, Zhonghua; ZHAO, Xianrui; WO2010/14939; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia