Synthetic Route of 923595-58-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 923595-58-8, name is 5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
To a solution of (R)-3-iluotO-2-(pyrrolidin-2-yl)pyridine (1 163 mg, 4.302 mmol) and 5-chloro-3-iodopyrazolo[l,5-a]pyrimidine (1.76 g, 6.298 mmol) in DMF (15 mL) was DIPEA (4.9 mL, 27.99 mmol). The mixture was stirred at 110 C for 1 hour and then cooled to rt overnight. The mixture was extracted with AcOEt, dried and concentrated. The product was purified by column chromatography using 0-100% acetone in hexane. Product was isolated as an orange oil (1.42 g, 50%).
According to the analysis of related databases, 923595-58-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PYRAMID BIOSCIENCES, INC.; PAL, Kollol; CIBLAT, Stephane; ALBERT, Vincent; BRUNEAU-LATOUR, Nicolas; BOUDREAULT, Jonathan; (139 pag.)WO2019/118584; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia