Synthetic Route of 926304-76-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 926304-76-9 as follows.
To a solution of the above pyrimidine (428 mg, 1.38 mmol), bis(triphenylphosphine)palladium(II) dichloride (145 mg, 0.207 mmol) and LiCl (289 mg, 6.9 mmol) in degassed DMF (5 mL) was added tributyl(vinyl)tin (0.48 mL, 1.64 mmol) and the mixture was heated at 1000C overnight. Standard work-up and purification afforded 4-(5- vinyl-pyrimidin-2-yloxy)-benzoic acid methyl ester (210 mg, 59%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,926304-76-9, its application will become more common.
Reference:
Patent; ANORMED INC.; WO2007/22371; (2007); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia