Related Products of 927801-23-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 927801-23-8 as follows.
General procedure: 6-Bromo-4-iodoquinoline (12) (1.0 equiv), Pd(PPh3)2Cl2 (0.1 equiv), CuI (0.15 equiv) and triethylamine were charged in a three neck round bottom flask. The flaskwas fitted with a N2 inlet adapterand purged with N2 for 10 min. The solution of alkyne (1.0 equiv)was then added via syringe and purged with N2 for another 10 min. The reaction mixture was stirred at 50 C for 5 h. After thecompletion of reaction, the mixture was concentrated underreduced pressure and the residue was dissolved in EtOAc, washedwith 1 N NaOH and water, then the organic phase was dried over magnesium sulfate. The crude product was purified by silica gel column chromatography yielded the desired compound. 4.1.12.3 6-Bromo-4-(3-(4-methylpiperazin-1-yl)prop-1-ynyl)quinoline (14c) This compound was prepared from 6-bromo-4-iodoquinoline (12) (100 mg, 0.30 mmol) and 1-methyl-4-(prop-2-ynyl)piperazine (13c) (41 mg, 0.30 mmol) according to the general synthesis procedure E to afford the title compound (62 mg, 0.18 mmol, 60% yield) as a viscous oil. 1H NMR (500 MHz, CDCl3) delta 8.87 (d, J = 4.5 Hz, 1H, Ar-H), 8.36 (d, J = 2.0 Hz, 1H, Ar-H), 7.98 (d, J = 9.0 Hz, 1H, Ar-H), 7.80 (dd, J = 9.0, 2.0 Hz, 1H, Ar-H), 7.61 (d, J = 4.5 Hz, 1H, Ar-H), 3.76 (s, 2H, CH2), 3.01-2.85 (m, 8H, CH2 * 4), 2.57 (s, 3H, CH3). ESI-MS: m/z = 344 [M+H]+.
According to the analysis of related databases, 927801-23-8, the application of this compound in the production field has become more and more popular.