As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 931-61-3, name is 2-Methylaminopyrimidine, molecular formula is C5H7N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 2-Methylaminopyrimidine
Example 7(15) A mixture of 1-76 (220 mg, 0.528 mmol), 2-methylaminopyrimidine (58 mg, 0.528 mmol) and 4-(dimethylamino)pyridine (0.6 mg, 0.005 mmol) in acetonitrile (2 mL) was stirred at 85 C for 16 h. Then, hydrazine hydrate (179 mu, 3.7 mmol) was added and the mixture was stirred at 100 C for 10 min under microwave irradiation. Then, the solvent was evaporated in vacuo and the crude product was purified by flash column chromatography (silica; MeOH in DCM 0/100 to 10/90). The desired fractions were collected and the solvents evaporated in vacuo to yield Co. No. 15 (135 mg, 65%) as a yellow solid. 1H NMR (500 MHz, CDC13) delta ppm 1.70 (d, J=6.4 Hz, 3 H) 2.94 (s, 3 H) 3.96 (dd, J=12.6, 7.4 Hz, 1 H) 4.23 (dd, J=12.6, 4.2 Hz, 1 H) 4.26 (br. s., 1 H) 4.66 – 4.75 (m, 1 H) 7.07 (s, 1 H) 7.51 (d, J=8.4 Hz, 2 H) 7.75 (d, J=8.4 Hz, 2 H) 7.83 (s, 1 H) 11.10 (br. s., 1 H).
With the rapid development of chemical substances, we look forward to future research findings about 931-61-3.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; VAN GOOL, Michiel, Luc, Maria; ALCAZAR-VACA, Manuel, Jesus; ALONSO-DE DIEGO, Sergio-Alvar; DE LUCAS OLIVARES, Ana, Isabel; (105 pag.)WO2016/87487; (2016); A1;,
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