Category: 932-52-5

Reference of 932-52-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.932-52-5, name is 5-Aminopyrimidine-2,4(1H,3H)-dione, molecular formula is C4H5N3O2, molecular weight is 127.1014, as common compound, the synthetic route is as follows.

Intermediate 1.1; Dimethyl (2E)-2-[(2.4-dioxo-1.2.3.4-tetrahvdro-5-pyriimdinvD-aminol-2-butenedioate (Scheme 7); To a suspension of 5-aminouracil (B)(4.0 g; 31.5 mmol; 1 eq.) in MeOH (120.00 mL) was added dimethyl acetylenedicarboxylate (C) (5.0 g; 35.2 mmol; 1.1 eq.). The suspension was stirred at room temperature for 46h. The reaction was monitored by NMR. The solid was filtered to afford dimethyl (2E)-2-[(2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl)amino]-2-butenedioate (8.0 g, 95%) (Intermediate 1.1).Amount: 8.0 g; Yield: 95%; Formula: Ci0HiiO6N3; HPLC Purity: 95% ; HPLC (HzO TFA Q.1%- ACN TFA Q.05%): Rt (min); Area % = 1.37; 93.61: 1H NMR (DMSO-d6) 8 3.64 (s, 3H), 3.66 (s, 3H), 5.21 (s, 1H), 7.42 (s, 1H), 9.07 (s, 1H), 10.86 (br, 1H), 11.31 (br, 1H); LC-MS:M/ZESI: Rt (min) 0.85 ; 210, 238, 270 (M+l) ; 208, 236, 268 (M-l).

Statistics shows that 932-52-5 is playing an increasingly important role. we look forward to future research findings about 5-Aminopyrimidine-2,4(1H,3H)-dione.

Reference:
Patent; APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.; WO2006/24666; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.932-52-5, name is 5-Aminopyrimidine-2,4(1H,3H)-dione, molecular formula is C4H5N3O2, molecular weight is 127.1014, as common compound, the synthetic route is as follows.COA of Formula: C4H5N3O2

Intermediate 4: 6-Methylpyridor3,2-c/lpyrirnidine-2,4(1H,3H)-dione; A mixture of 5-aminouracil (3 g; 23.6 mmol; 1 eq.) and crotonaldehyde (2.04 ml 24.8 mmol; 1.05 eq.) in 20% HCI (20 ml.) was stirred at 1 100C for 1 hour. The solution was evaporated in vacuo and the residue precipitated from EtOH to afford the title compound as a black solid. 1H NMR (300 MHz, DMSO-d6) delta 8.90-8.50 (m, 2H), 7.80 (d, 1 H), 7.51 (d, 1 H), 2.50 (s, 3H). MS (ES+): 178.1.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,932-52-5, 5-Aminopyrimidine-2,4(1H,3H)-dione, and friends who are interested can also refer to it.

Reference:
Patent; MERCK SERONO S.A.; POMEL, Vincent; GAILLARD, Pascale; DESFORGES, Gwenaelle; QUATTROPANI, Anna; MONTAGNE, Cyril; WO2010/37765; (2010); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 932-52-5, name is 5-Aminopyrimidine-2,4(1H,3H)-dione. A new synthetic method of this compound is introduced below., Application In Synthesis of 5-Aminopyrimidine-2,4(1H,3H)-dione

General procedure: To a mixture of 5-aminouracil (127 mg, 1 mmol) with an appropriate aldehyde (241 mg, 1.2 mmol) in methanol (15 mL) were added few drops of glacial acetic acid. The reaction mixture was stirred at room temperature until 5-aminouracil was completely consumed (TLC). The precipitate was filtered off, washed with methanol and air dried to give the corresponding product 1-10 as a yellow solid.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 932-52-5, 5-Aminopyrimidine-2,4(1H,3H)-dione.

Reference:
Article; Koz; Russian Journal of General Chemistry; vol. 89; 1; (2019); p. 122 – 127; Zh. Obshch. Khim.; vol. 89; 1; (2019); p. 122 – 127,6;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 932-52-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 932-52-5, name is 5-Aminopyrimidine-2,4(1H,3H)-dione. A new synthetic method of this compound is introduced below.

General procedure: To a mixture of 5-aminouracil (127 mg, 1 mmol) with an appropriate aldehyde (241 mg, 1.2 mmol) in methanol (15 mL) were added few drops of glacial acetic acid. The reaction mixture was stirred at room temperature until 5-aminouracil was completely consumed (TLC). The precipitate was filtered off, washed with methanol and air dried to give the corresponding product 1-10 as a yellow solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,932-52-5, its application will become more common.

Reference:
Article; Koz; Russian Journal of General Chemistry; vol. 89; 1; (2019); p. 122 – 127; Zh. Obshch. Khim.; vol. 89; 1; (2019); p. 122 – 127,6;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 932-52-5, Adding some certain compound to certain chemical reactions, such as: 932-52-5, name is 5-Aminopyrimidine-2,4(1H,3H)-dione,molecular formula is C4H5N3O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 932-52-5.

General procedure: A suspension of 5-aminouracil 1 (1 mmol) in dry pyridine (7.5 mL) was cooled to 0 C and the appropriate sulfonyl chloride (1 mmol) was added. The reaction mixture was stirred at room temperature until the TLC showed the reaction was completed (1.5-20 h). The solvent was removed under reduced pressure and the crude product was recrystallized from methanol or aqueous methanol to afford the product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 932-52-5, 5-Aminopyrimidine-2,4(1H,3H)-dione, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ismaili, Hamit; Ban, ?eljka; Mati?, Josipa; Safti?, Dijana; Juki?, Marijana; Glava?-Obrovac, Ljubica; ?ini?, Biserka; Croatica Chemica Acta; vol. 92; 2; (2019); p. 269 – 277;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

932-52-5, A common compound: 932-52-5, name is 5-Aminopyrimidine-2,4(1H,3H)-dione,molecular formula is C4H5N3O2, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

Equipped with a stirrer, thermometer, reflux condenser, the reaction vessel was added 1-amino-phthalide (2) 0.23mol, 5- aminouracil 0.28 mol, stannous chloride 0.31mol, 75% mass fraction cyclohexyl 230ml dioxane, stirred at 170 rpm and speed control, batches of 35% mass fraction of 0.13 mol sodium sulfite solution, the reaction was stirred 7H, filtered, and the filtrate was concentrated under reduced pressure the cyclohexane distilled off, added 630ml of 15% mass fraction of KCl , the precipitated solid was filtered, washed with sodium bromide solution, dried over anhydrous magnesium sulfate, was added to a mass fraction of 80% acetonitrile, and the solution temperature rises to 65 , 80min after filtration, the mass fraction of 95% nitromethane recrystallized to give crystals of 1- phthalide 5-amino-uracil 53.63g, yield 89%.

With the rapid development of chemical substances, we look forward to future research findings about 932-52-5.

Reference:
Patent; Chengdu Chester Technology Co., Ltd.; Peng, Fei; (5 pag.)CN105481837; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

932-52-5, Adding a certain compound to certain chemical reactions, such as: 932-52-5, 5-Aminopyrimidine-2,4(1H,3H)-dione, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 932-52-5, blongs to pyrimidines compound.

General procedure: A suspension of 5-aminouracil 1 (1 mmol) in dry pyridine (7.5 mL) was cooled to 0 C and the appropriate sulfonyl chloride (1 mmol) was added. The reaction mixture was stirred at room temperature until the TLC showed the reaction was completed (1.5-20 h). The solvent was removed under reduced pressure and the crude product was recrystallized from methanol or aqueous methanol to afford the product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,932-52-5, its application will become more common.

Reference:
Article; Ismaili, Hamit; Ban, ?eljka; Mati?, Josipa; Safti?, Dijana; Juki?, Marijana; Glava?-Obrovac, Ljubica; ?ini?, Biserka; Croatica Chemica Acta; vol. 92; 2; (2019); p. 269 – 277;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

932-52-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 932-52-5, name is 5-Aminopyrimidine-2,4(1H,3H)-dione. This compound has unique chemical properties. The synthetic route is as follows.

Example 26-methylpyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione 2 Into a 2000-mL 4-necked round-bottom flask was placed a solution of 5-aminopyrimidine-2,4(1H,3H)-dione 1 (217 g, 1.71 mol, 1.00 equiv) in HCl (20%, 1302 mL), then added (E)-but-2-enal (143.5 g, 2.05 mol, 1.20 equiv). The resulting solution was heated to reflux for 3 h (hours) in an oil bath. The reaction mixture was cooled and filtered. The filtrate was concentrated under vacuum. The residual solution was diluted with 250 mL of water and adjusted to pH 10 with ammonia (25%). The isolated solid was collected by filtration, then washed with 2¡Á100 mL of water, 2¡Á250 ml of ethanol and 3¡Á500 mL of ether and finally dried in an oven. This resulted in 63 g (21%) of 6-methylpyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione 2. 1H-NMR (400 MHz, CD3OD, ppm): 7.56 (2H, s), 2.60 (3H, s)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 932-52-5, 5-Aminopyrimidine-2,4(1H,3H)-dione.

Reference:
Patent; Castanedo, Georgette; Chan, Bryan; Lucas, Matthew C.; Safina, Brian; Sutherlin, Daniel P.; Sweeney, Zachary; US2011/207713; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

932-52-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 932-52-5, name is 5-Aminopyrimidine-2,4(1H,3H)-dione, molecular formula is C4H5N3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Heterocyclic amides Compound 2 and Compound 4 were prepared by the reaction ofGlycyrrhizin with 5-aminouracyl and 6-amino-2-thio-uracyl the presence of DCC.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 932-52-5, 5-Aminopyrimidine-2,4(1H,3H)-dione, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; JOHANN WOLFGANG GOETHE UNIVERSITY; WO2004/108122; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

932-52-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 932-52-5, name is 5-Aminopyrimidine-2,4(1H,3H)-dione. This compound has unique chemical properties. The synthetic route is as follows.

Intermediate 1 : Dimethyl (2E)-2-r(2,4-dioxo-1 ,2,3,4-tetrahvdropyrimidin-5-yl)amino1but- 2-enedioate; To a suspension of 5-aminouracil (275 g, 2.16 mol) in dry methanol (5.5 L) was added dropwise dimethyl acetylene dicarboxylate (344 g, 2.42 mol) at room temperature. After the end of the addition, the mixture was stirred at room temperature for 24 hours. The precipitate was filtered off, washed with MeOH (500 mL) and dried under vacuum to afford the title compound (430 g, 74%) as a yellow solid.LC/MS (Method A) : RT 0.87 min (purity : 96%). MS (ES-) : 267.6. 1H NMR (400 MHz, DMSO-ds) delta 11.33 (br s, 1 H), 10.82 (br s, 1 H), 9.07 (s, 1 H), 7.42 (s, 1 H),5.21 (s, 1 H), 3.65 (s, 3H), 3.63 (s, 3H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 932-52-5, 5-Aminopyrimidine-2,4(1H,3H)-dione.

Reference:
Patent; MERCK SERONO S.A.; MONTAGNE, Cyril; BOMBRUN, Agnes; DESFORGES, Gwenaelle; QUATTROPANI, Anna; GAILLARD, Pascale; WO2010/91996; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia