93366-88-2 | Pyrimidines

9 Sep 2021 News The origin of a common compound about 93366-88-2

Statistics shows that 93366-88-2 is playing an increasingly important role. we look forward to future research findings about 7H-Pyrrolo[2,3-d]pyrimidin-2-amine.

Electric Literature of 93366-88-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.93366-88-2, name is 7H-Pyrrolo[2,3-d]pyrimidin-2-amine, molecular formula is C6H6N4, molecular weight is 134.14, as common compound, the synthetic route is as follows.

7H-pyrrolo[2,3-d]pyrimidin-2-amine (134 mg, 1.00 mmol), 2-bromo-5-fluoro-4-iodopyridine (604 mg, 2.00mmol),potassium carbonate (415 mg, 3.00 mmol) and proline (23 mg, 0.2 mmol) was added to the eggplant flask,dimethyl sulfoxide was added, and the reaction solution was deoxidized. Copper iodide (19 mg, 0.1 mmol) was added and the reaction solution was deoxygenated. Heat to 90 C and stir for 16 hours. After the reactionwas completed, it was cooled to room temperature, water and ethyl acetate were added, and the mixture was filtered over celite. The target compound was obtained in 246 mg.

Statistics shows that 93366-88-2 is playing an increasingly important role. we look forward to future research findings about 7H-Pyrrolo[2,3-d]pyrimidin-2-amine.

Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Zhao Yujun; Li Zhiqiang; Yan Ziqin; Li Jia; Zhou Yubo; Su Mingbo; Chen Zheng; (138 pag.)CN109810110; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

A new synthetic route of 7H-Pyrrolo[2,3-d]pyrimidin-2-amine

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 93366-88-2, 7H-Pyrrolo[2,3-d]pyrimidin-2-amine.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 93366-88-2, name is 7H-Pyrrolo[2,3-d]pyrimidin-2-amine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 93366-88-2

2 ‘ ,3 ‘ -Dideoxy-2 ‘ -fluoro-5 ‘ -O-tert-butyldimethylsilyl-4-chloro-7-deazaguanosine 18 A mixture of l-Chloro-2,3-dideoxy-2-fluoro-5-tert-butyldimethylsilylribose 17(880 mg, 2.24 mmol), 7-deazaguanidine (755 mg, 4.48 mmol), and powdered potassium hydroxide (377 mg, 6.72 mmol) in anhydrous acetonitrile (15 mL) was treated with catalytic amount of tris(2-(2- methoxyethoxy)ethyl) amine (72 mg, 0.224 mmol). After 12 h at rt, the mixture was concentrated and the resulting residue partitioned between ethyl acetate (100 mL) and water (50 mL). The aqueous phase was back extracted with ethyl acetate (2 x 25 mL) and the combined organic phases dried over sodium sulfate, filtered and concentrated to dryness. The crude material was purified by flash column chromatography (25 mm x 170 mm) over silica gel using 9: 1 hexanes: ethyl acetate to give 18 (540 mg, 46%) as a white foam. 1H NMR (400 MHz, Chloroform-;/) delta 7.70 – 7.60 (m, 3H), 7.48 – 7.30 (m, 8H), 6.33 (d, J = 18.1 Hz, 1H), 6.25 (d, J = 3.8 Hz, 1H), 5.29 (dd, J = 51.9, 4.3 Hz, 1H), 4.96 (s, 2H), 4.48 (ddt, J = 11.1, 5.5, 3.1 Hz, 1H), 4.07 (dd, J = 11.8 Hz, 3.0 Hz, 1H), 3.76 (dd, J = 11.8, 3.3 Hz, 1H), 2.57 – 2.37 (m, 1H), 2.20 (ddd, J= 19.8, 14.3, 5.2 Hz, 1H), 1.07 (s, 9H).

Reference:
Patent; EMORY UNIVERSITY; LIOTTA, Dennis, C.; PAINTER, George, R.; BLUEMLING, Gregory, R.; WO2014/124430; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 7H-Pyrrolo[2,3-d]pyrimidin-2-amine

According to the analysis of related databases, 93366-88-2, the application of this compound in the production field has become more and more popular.

Related Products of 93366-88-2, Adding some certain compound to certain chemical reactions, such as: 93366-88-2, name is 7H-Pyrrolo[2,3-d]pyrimidin-2-amine,molecular formula is C6H6N4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 93366-88-2.

7H-pyrrolo[2,3-d]pyrimidin-2-amine (134 mg, 1.00 mmol), QC130 (381 mg, 1.29 mmol), potassium carbonate(415 mg, 3.00 mmol) and valine (23 mg, 0.2 mmol) It was added to an eggplant type flask, dimethyl sulfoxide wasadded, and the reaction solution was deoxidized. Copper iodide (19 mg, 0.1 mmol) was added and the reactionsolution was deoxygenated. Heat to 90C and stir for 16 hours. After the reaction was completed, it was cooledto room temperature, water and ethyl acetate were added, and the mixture was filtered over Celite. The targetcompound was obtained in an amount of 110 mg.

According to the analysis of related databases, 93366-88-2, the application of this compound in the production field has become more and more popular.

Sources of common compounds: 7H-Pyrrolo[2,3-d]pyrimidin-2-amine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,93366-88-2, 7H-Pyrrolo[2,3-d]pyrimidin-2-amine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 93366-88-2, 7H-Pyrrolo[2,3-d]pyrimidin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C6H6N4, blongs to pyrimidines compound. Computed Properties of C6H6N4

7H-pyrrolo[2,3-d]pyrimidin-2-amine (270 mg, 2.01 mmol), 4-bromo-1-fluoro-2-iodobenzene (1.28 g, 4.26mmol), potassium carbonate (840 mg, 6.09) and proline (92 mg, 0.80 mmol) were added to an eggplantflask, dimethyl sulfoxide was added, and the reaction solution was deoxygenated. Copper iodide (114 mg, 0.60mmol) was added and the reaction solution was deoxygenated. Heat to 90 C and stir for 16 hours. After thereaction was completed, it was cooled to room temperature, water and ethyl acetate were added, and the mixturewas filtered over Celite. The target compound was obtained in 240 mg.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,93366-88-2, 7H-Pyrrolo[2,3-d]pyrimidin-2-amine, and friends who are interested can also refer to it.

Brief introduction of 93366-88-2

7H-pyrrolo[2,3-d]pyrimidin-2-amine (160 mg, 1.19 mmol), 3-bromo-5-iodopyridine (676 mg, 2.39 mmol),potassium carbonate (493 mg, 3.57 mmol) and proline(28 mg, 0.24 mmol) was added to an eggplant flask, dimethyl sulfoxide was added, and the reaction solution was deoxidized. Copper iodide (23 mg, 0.12mmol) was added and the reaction solution was deoxygenated. Heat to 90 C and stir for 16 hours. After the reaction was completed, it was cooled to room temperature, water and ethyl acetate were added, and the mixture was filtered over celite. The target compound was obtained in 24 mg.

Extracurricular laboratory: Synthetic route of 93366-88-2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,93366-88-2, its application will become more common.

Electric Literature of 93366-88-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 93366-88-2 as follows.

The final product 03 (20 mg, 0.062 mmol), 2-amino-7H-pyrrolo [2,3-d] pyrimidine (25 mg, 0.186 mmol) and Et3N (25 mg, 0.25 mmol) were weighed into a bottle,Add 2 mL of DMF to dissolve the reaction reagent.The reaction was heated at 50 C overnight.The crude reaction product was directly purified by reverse-phase HPLC to obtain the target compound YC124 (18.8 mg).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,93366-88-2, its application will become more common.

Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Zhao Yujun; Li Jia; Wang Zengtao; Zhang Shiyan; Zang Yi; Wang Peipei; Sun Dandan; Zhang Hanyan; (155 pag.)CN110818683; (2020); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 93366-88-2

At the same time, in my other blogs, there are other synthetic methods of this type of compound,93366-88-2, 7H-Pyrrolo[2,3-d]pyrimidin-2-amine, and friends who are interested can also refer to it.

93366-88-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 93366-88-2, name is 7H-Pyrrolo[2,3-d]pyrimidin-2-amine. A new synthetic method of this compound is introduced below.

7H-pyrrolo[2,3-d]pyrimidin-2-amine (388 mg, 2.90 mmol), 4-bromo-2-iodo-1-methoxybenzene (2.56 g, 8.64mmol), potassium carbonate (1.66) Mg, 12.03 mmol) and valine (83 mg, 0.72 mmol) were added to an eggplantflask, dimethyl sulfoxide was added, and the reaction solution was deoxidized. Copper iodide (60 mg, 0.31mmol) was added and the reaction solution was deoxygenated. Heat to 90C and stir for 16 hours. After the reaction was completed, it was cooled to room temperature, water and ethyl acetate were added, and the mixturewas filtered over Celite. The target compound was obtained in 60 mg.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,93366-88-2, 7H-Pyrrolo[2,3-d]pyrimidin-2-amine, and friends who are interested can also refer to it.