Category: 933702-55-7

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.933702-55-7, name is 2-Chloropyrimidine-5-carbaldehyde, molecular formula is C5H3ClN2O, molecular weight is 142.5431, as common compound, the synthetic route is as follows.Formula: C5H3ClN2O

To a solution of 1.00 g (1.48 mmol) of (-)-4-(4,4-Difluorocyclohexyl)-3-{fluoro[4-(trifluoromethyl)phenyl]methyl}-5-[(4-methoxybenzyl)oxy]-7,7-dimethyl-2-(piperidin-4-yl)-5,6,7,8-tetrahydroquinoline, which was prepared by a method similar to that of Reference Example 10, in 5 ml of 1-methyl-2-pyrrolidone, 0.23 g (1.6 mmol) of 2-chloro-5-formyl pyrimidine and 265 mul (1.78 mmol) of diazabicycloundecene were added, and the reaction solution was stirred at room temperature for 1 hour. Then, 0.023 g (0.16 mmol) of 2-chloro-5-formyl pyrimidine was added thereto and the reaction solution was further stirred at room temperature for 0.58 hours. Furthermore, 0.023 g (0.16 mmol) of 2-chloro-5-formyl pyrimidine was added thereto and the reaction solution was stirred at room temperature for 1.5 hours. After completion of the reaction, the reaction solution was poured into saturated sodium hydrogencarbonate aqueous solution and extracted with ethyl acetate. The organic layer was washed with saturated sodium chloride aqueous solution and dried with anhydrous magnesium sulfate, and then the solvent was distilled off under reduced pressure. The obtained residue was subjected to silica gel column chromatography [n-hexane/ethyl acetate=40/10 (V/V)] and the fraction including the desired compound was concentrated under reduced pressure to provide 1.00 g of the title compound as a light yellow solid (yield: 87%). 1H-NMR spectrum (300 MHz, CDCl3) delta ppm: 9.71 (1H, s), 8.65 (2H, s), 7.63 (2H, d, J=8 Hz), 7.37 (2H, d, J=8 Hz), 7.25 (2H, d, J=9 Hz), 7.16 (1H, d, J=48 Hz), 6.87 (2H, d, J=9 Hz), 5.03-4.91 (1H, m), 4.83 (1H, t, J=5 Hz), 4.81 (1H, d, J=11 Hz), 4.77-4.67 (1H, m), 4.39 (1H, d, J=11 Hz), 3.79 (3H, s), 3.25-3.09 (1H, m), 2.92-2.74 (2H, m), 2.84 (1H, d, J=17 Hz), 2.65 (1H, d, J=17 Hz), 2.34-1.46 (14H, m), 1.19 (3H, s), 1.03 (3H, s), 0.79-0.68 (1H, m). Mass spectrum (EI, m/z): 780 [M+].

At the same time, in my other blogs, there are other synthetic methods of this type of compound,933702-55-7, 2-Chloropyrimidine-5-carbaldehyde, and friends who are interested can also refer to it.

Reference:
Patent; UBE INDUSTRIES, LTD.; DAIICHI SANKYO COMPANY, LIMITED; Nakamura, Tsuyoshi; Namiki, Hidenori; Terasaka, Naoki; Shima, Akiko; Hagihara, Masahiko; Iwase, Noriaki; Takata, Katsunori; Kikuchi, Osamu; Tsuboike, Kazunari; Setoguchi, Hiroyuki; Yoneda, Kenji; Sunamoto, Hidetoshi; Ito, Koji; US2013/109653; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 933702-55-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 933702-55-7, name is 2-Chloropyrimidine-5-carbaldehyde. This compound has unique chemical properties. The synthetic route is as follows.

2401-2403, in 16 ml of tetrahydrofuran was cooled to 0 C. and 1.6 ml (2.6 mmol) of 1.7 N n-butyl lithium/n-hexane solution was added thereto, and the reaction solution was stirred at room temperature for 30 minutes. The reaction solution was cooled to 0 C. again and then a solution of 0.31 g (2.2 mmol) of 2-chloropyrimidin-5-carbaldehyde in 4 ml of tetrahydrofuran was added to the reaction solution, and the reaction solution was stirred at room temperature for 30 minutes. After completion of the reaction, saturated ammonium chloride aqueous solution was added to the reaction solution and the reaction solution was extracted with ethyl acetate. The organic layer was washed with saturated sodium chloride aqueous solution and dried with anhydrous sodium sulfate, and then the solvent was distilled off under reduced pressure. The obtained residue was subjected to silica gel column chromatography [n-hexane/ethyl acetate=100/0-80/20 (V/V)] and the fraction including the desired compound was concentrated under reduced pressure to provide 0.17 g of 2-chloro-5-(4,4,4-trifluoro-1-buten-1-yl)pyrimidine.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 933702-55-7, 2-Chloropyrimidine-5-carbaldehyde.

Reference:
Patent; UBE INDUSTRIES, LTD.; DAIICHI SANKYO COMPANY, LIMITED; Nakamura, Tsuyoshi; Namiki, Hidenori; Terasaka, Naoki; Shima, Akiko; Hagihara, Masahiko; Iwase, Noriaki; Takata, Katsunori; Kikuchi, Osamu; Tsuboike, Kazunari; Setoguchi, Hiroyuki; Yoneda, Kenji; Sunamoto, Hidetoshi; Ito, Koji; US2013/109653; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 933702-55-7, name is 2-Chloropyrimidine-5-carbaldehyde. This compound has unique chemical properties. The synthetic route is as follows. Safety of 2-Chloropyrimidine-5-carbaldehyde

To a suspension of bromo(2,6-difluoro-3,5-dimethoxybenzyl)triphenyl- 5-phosphane (Example 513, step (d) (4.9g, 9.29 mmol) in anhydrous THF (lOmL) was added 60% NaH (0.5g, 12.67 mmol) portionwise at 0 C under argon atmosphere. The resultant reaction mixture was stirred at room temperature for 12h. A solution of 2-chloropyrimidine-5-carbaldehyde (1.2g, 8.45 mmol) in anhydrous THF (5mL) was added dropwise for 15min. and stirring was continued for overnight at room temperature. The reaction mixture was quenched with ice water and ethyl acetate. The aqueous layer was separated and extracted with ethyl acetate (3x50mL). The combined organic phase was washed with brine, dried over Na2S04, filtered and concentrated under vacuum. The residue was purified by trituration with ether to afford desired title compound (0.45g, 17.3%) LCMS: m/z = 313.2 (M+H)+.

With the rapid development of chemical substances, we look forward to future research findings about 933702-55-7.

Reference:
Patent; EISAI R & D MANAGEMENT CO., LTD.; REYNOLDS, Dominic; HAO, Ming-Hong; WANG, John; PRAJAPATI, Sundeep; SATOH, Takashi; SELVARAJ, Anand; (128 pag.)WO2016/164703; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 933702-55-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 933702-55-7, name is 2-Chloropyrimidine-5-carbaldehyde, molecular formula is C5H3ClN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(3) Add 5.4 g (37.5 mmol) of 2-chloropyrimidin-5-formaldehyde, 5.0 g (31.2 mmol) of intermediate 2 and 30 ml of methanol to a 150 ml single-mouth bottle, stir and mix well, and add 0.4 g of ethylene to the mixture. The amine is heated to reflux 12, and the reaction is completed. After cooling the reaction product to room temperature, it was extracted with dichloromethane, washed with water, dried over anhydrous sodium sulfate, filtered, and evaporated.Dichloromethane was removed by distillation to give a crude material (yield: petroleum ether) to give the product 5-(2-chloropyrimidine-5-)methylene-4-phenylfuran-2 (5H) – Ketone 6.7 g, yield 62.8%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 933702-55-7, 2-Chloropyrimidine-5-carbaldehyde.

Reference:
Patent; Yangtze University; Wu Qinglai; Cai Jinlong; (28 pag.)CN109761939; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 933702-55-7 ,Some common heterocyclic compound, 933702-55-7, molecular formula is C5H3ClN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Dissolve 2-chloropyrimidine5-carhaldehyde (0.5 g, 3.5 mmol) in chloroform (10 mL), add diethyiaminosuifur trioxide (567 mg, 3,5 mmoi), then reflux for 1 hour. Cool the mixture to ambient temperature and quench with 1-120. Separate the layers, wash the organic fraction with 1-120 (2x), dry over Mg504, filter, collect the filtrate, and concentrate the filtrate under reduced pressure to provide the title product (327 mg, 51%),

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 933702-55-7, 2-Chloropyrimidine-5-carbaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ELI LILLY AND COMPANY; ESCRIBANO, Ana Maria; GONZALEZ, Maria Rosario; LAFUENTE BLANCO, Celia; MARTIN-ORTEGA FINGER, Maria Dolores; WILEY, Michael R.; (82 pag.)WO2016/187384; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 933702-55-7, 2-Chloropyrimidine-5-carbaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 933702-55-7, blongs to pyrimidines compound. Application In Synthesis of 2-Chloropyrimidine-5-carbaldehyde

To a solution of 2-chloropyrirnidine-5-carbaldehyde (0.30 g, 2.11 mmol) in THE (10 mL) was added intermediate 74 (0.36 g, 1.75 mmoi) and the reaction mixture was stirred at ambient temperature for 1 h. To the resulting solution was added sodium cyanoborohydride (0.27 g, 4.38 mmoi) and MeOH (mu.) and stirring was continued for 14 h. The reaction mixture was dilutedwith water (20 mL) and extracted with 7% MeOH:DCM (3 x 30 mL), The combined organic layers were dried over anhydrous sodium sulfate and evaporated under reduced pressure. The residue was triturated with DCM/n-hexane to obtain Intermediate 98 (0.45 g, 43.00%), ?Fl NMR (400 MHz, DMSO-d6) ppm 2.23 (s, 3 H), 2.59-2.67 (rn, 2 H), 3.17 (d, J 4.16 Hz, I H), 3.80 (s, I H), 4.57 (d, J= 4.65 Hz, I H), 5.01 (d, J= 3.67 Hz, I H), 5.38 (d, J= 3.42 Hz, 2El), 5.48 – 5.62 (m, I H). 7.56 – 7.74 (m, 2 H). 8.64 – 8.76 (m, 2 H). LCMS (Aithod-O): retention time 0.72 mm, [M+H1 334.5

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,933702-55-7, its application will become more common.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; GUNAGA, Prashantha; BHIDE, Rajeev S.; BORA, Rajesh Onkardas; PANDA, Manoranjan; YADAV, Navnath Dnyanoba; PRIESTLEY, Eldon Scott; RICHTER, Jeremy; (321 pag.)WO2018/93569; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia