Category: 936643-80-0

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 936643-80-0, name is 2-(Chloromethyl)pyrimidine hydrochloride, the common compound, a new synthetic route is introduced below. Application In Synthesis of 2-(Chloromethyl)pyrimidine hydrochloride

To methyl 2-(3-acetyl-5-hydroxy-1 H-indazol-1 -yl)acetate (1.80 g, 7.25 mmol) in CH3CN (75 mL) was added 2-(chloromethyl)pyrimidine hydrochloride (1.32 g, 7.98 mmol) and Cs2C03 (5.91 g, 18.13 mmol). The reaction mixture was stirred at 70C for 2 h. The reaction mixture was filtered and washed with CH3CN. The solvent was removed under reduced pressure and the crude residue was purified by flash column chromatography on silica gel (c-hexane/EtOAc 1 :1 to 1 :3). TLC, Rf (c-hexane/EtOAc 1 :3) = 0.35; MS (LC/MS): 340.9 [M+H]+, 363.0 [M+Na]+; tR (HPLC conditions e): 3.64 min.

The synthetic route of 936643-80-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOVARTIS AG; FLOHR, Stefanie; HOMMEL, Ulrich; LORTHIOIS, Edwige, Liliane, Jeanne; MAIBAUM, Juergen, Klaus; OSTERMANN, Nils; RANDL, Stefan, Andreas; VULPETTI, Anna; QUANCARD, Jean; WO2014/2052; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 936643-80-0, name is 2-(Chloromethyl)pyrimidine hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 936643-80-0

To a stirred solution of 38-D (75 mg, 0.232 mmol) in DMF (6 mL) was added K2CO3 (128 mg, 0.928 mmol), followed by 38-E (57 mg, 0.348 mmol). The resulting mixture was stirred at 70 C. overnight. Diluted the reaction mixture with EtOAc and washed with H2O. The organic layer was dried over Na2SO4 and evaporated in vacuo. The residue was then purified by column chromatography (EtOAc:hexanes=2:3) to afford Compound II-56.

With the rapid development of chemical substances, we look forward to future research findings about 936643-80-0.

Reference:
Patent; Gilead Sciences, Inc.; US2012/289493; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 936643-80-0, name is 2-(Chloromethyl)pyrimidine hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 936643-80-0

First Step A solution of 4-nitro-m-cresol (0.25 g, 1.6 mmol), 2-(chloromethyl)pyrimidine hydrochloride (0.40 g, 2.4 mmol) and potassium carbonate (0.50 g, 4.0 mmol) in N,N-dimethylformamide (6.0 mL) was stirred at 70 C. for 18 h. Cooled to ambient temperature, the reaction mixture was poured into ice water, extracted with ethyl acetate. The organic layer was washed with water and brine, dried over sodium sulfate, filtered and concentrated to afford 2-[(3-methyl-4-nitrophenoxy)methyl]pyrimidine as crude material (0.32 g, y. 81%) as solid. 1H NMR (DMSO-d6) delta (ppm) 8.84 (d, J=4.92 Hz, 2H), 8.03 (d, J=9.08 Hz, 1H), 7.48 (t, J=4.90 Hz, 1H), 7.10 (d, J=2.68 Hz, 1H), 7.00 (dd, J=2.80, 9.12 Hz, 1H), 5.43 (s, 2H), 2.53 (s, 3H); LCMS (m/z): 246.4 [M+H]+.

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Reference:
Patent; CARNA BIOSCIENCES, INC.; SBI BIOTECH CO., LTD.; Irie, Takayuki; Sawa, Ayako; Sawa, Masaaki; Asami, Tokiko; Funakoshi, Yoko; Tanaka, Chika; US2014/18533; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 936643-80-0, name is 2-(Chloromethyl)pyrimidine hydrochloride, molecular formula is C5H6Cl2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 936643-80-0

A solution of 1 -(5-(4,4,5, 5-tetramethyl- 1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazine (1 .0 g, 3.5 mmol), 2-(chloromethyl)pyrimidine hydrochloride (0.68 g, 4.1 mmol), and Cs2CO3 (2.8 g, 8.6 mmol) in DMF (6 mL) was stirred overnight at ambient temperature, and then at 50 C until LCMS indicated reaction completion. After cooling to ambient temperature, the reaction mixture was diluted with MTBE (20 mL), and extracted sequentially with 1:1 water: saturated NaHCO3(aq) (5 mL) and brine (3 x 5 mL). The organic extracts were dried over anhydrous Mg504, filtered, and concentrated in vacuo. The residue obtained was purified by silica chromatography (1-25% DCM-MeOH as the gradient eluent) to afford the title compound (500 mg, 38% yield). ?H NMR (400 IVIFIz, CDC13) 8.76-8.75 (d, 2H), 8.54-8.53 (d, 1H), 7.82-7.79 (dd, 1H), 7.22-7.20 (t, 1H), 6.59-6.57 (d, 1H), 3.88 (s, 2H), 3.71-3.68 (m, 4H), 2.70-2.68 (m, 4H), 1.31 (s, 12H).

With the rapid development of chemical substances, we look forward to future research findings about 936643-80-0.

Reference:
Patent; ARRAY BIOPHARMA, INC.; ANDREWS, Steven W.; BLAKE, James F.; CHICARELLI, Mark J.; GOLOS, Adam; HAAS, Julia; JIANG, Yutong; KOLAKOWSKI, Gabrielle R.; (594 pag.)WO2017/11776; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia