Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 945016-63-7, name is 3-(2-Chloropyrimidin-4-yl)-1H-indole. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 945016-63-7
Sodium hydride (2.7 g, 60% in mineral oil) was added portionwise to 3-(2- chloropyrimidin-4-yl)-1H-indole (12 g) in THF (250 mL) at 0 C. The resulting mixture was stirred at 0 C for 30 mm before CR93 (1.3 equiv.) was added. The mixture was stirred at 0 C for 1 h. The reaction was quenched by the addition of saturated aqueous NaHCO3 solution (400 mL) and EtOAc (400 mL). The orgamic layer was washed with saturated brine (200 mL). The organic layer was evaporated to afford crude product (compound 4, 9.3 g) as a pale orange solid.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 945016-63-7, 3-(2-Chloropyrimidin-4-yl)-1H-indole.
Reference:
Patent; NEUFORM PHARMACEUTICALS, INC.; CHAORAN, Huang; CHANGFU, Cheng; (85 pag.)WO2017/117070; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia