Category: 94741-69-2

Related Products of 94741-69-2 ,Some common heterocyclic compound, 94741-69-2, molecular formula is C5H3ClN4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 30 4-Amino-5-cyano-2-{4-[N-(3-hydroxy-2.2-dimethylpropyl)sulphamoyl]anilino}pyrimidine A solution of 4-amino-2-chloro-5-cyanopyrimidine (150 mg, 0.97 mmol), 4-[N-(3-hydroxy-2,2-dimethylpropyl)sulphamoyl]aniline (Method 4; 274 mg, 1.07 mmol) in NMP (5 ml) was heated at 120 C. for 24 hours. The mixture was allowed to cool, was diluted with water and extracted with ethyl acetate. The organic extracts were combined, dried and the solvent removed by evaporation. the residue was triturated with ether and the product collected by filtration to give the title compound (187 mg, 52%). NMR: 0.72 (s, 6H), 2.52 (d, 2H), 3.08 (d, 2H), 4.40 (t, 1H), 7.19 (t, 1H), 7.60 (s, 1H), 7.64 (d, 2H), 7.96 (d, 2H), 8.40 (s, 1H); m/z 375 (M-H)-.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,94741-69-2, its application will become more common.

Reference:
Patent; Thomas, Andrew Peter; US2003/87923; (2003); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 94741-69-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.94741-69-2, name is 4-Amino-2-chloro-5-pyrimidinecarbonitrile, molecular formula is C5H3ClN4, molecular weight is 154.56, as common compound, the synthetic route is as follows.

Step 5A: (2R)-4-(4-arnino-5-cvanopyrirnidin-2-yl)-N-[2-(l-benzylpiperidin-4- yl)ethyll-2-methylpiperazine-l -carboxamide (0311) To a solution of (2R)-N-[2-(l-benzylpiperidin-4-yl)ethyl]-2- methy lpiperazine- 1 -carboxamide 4a (0.20 g, 0.58 mmol, 1.0 eq) and 4-amino-2- chloropyrimidine-5-carbonitrile (0.90 g, 0.58 mmol, 1.0 eq) in NMP (2 mL) was added N,N-diisopropylethylamine (0.38 mL, 2.3 mmol, 4.0 eq) and the reaction mixture heated to 100 C for 1 hr. In some cases, lower temperatures or longer reaction times were used. The reaction mixture was cooled, diluted heavily with EtOAc, and washed repeatedly with brine (3x). The organic layer was dried over Na2SC>4 and concentrated. Silica gel column (24 g) was loaded using methylene chloride and run using an increasing gradient of MeOH (0-20%) in methylene chloride over 20 min to provide (2R)-4-(4-ainino-5-cyanopyrimidin-2-yl)-N-[2-(l-benzylpiperidin-4-yl)ethyl]-2- methylpiperazine-l-carboxamide 5-1 (0.14 g, 0.31 mmol, 53%) as an off-white foam.

The chemical industry reduces the impact on the environment during synthesis 94741-69-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; NEUROCRINE BIOSCIENCES, INC.; HARRIOTT, Nicole; PAGANO, Nicholas; (135 pag.)WO2017/79641; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 94741-69-2, name is 4-Amino-2-chloro-5-pyrimidinecarbonitrile, molecular formula is C5H3ClN4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 94741-69-2

EXAMPLE 94; A mixture of 2-chloro-5-cyano-6-amino pyrimdine (0,1 g), 3,4,5-trimethoxy aniline (0.71 mmol), palladium(II) acetate (1 mol%), 9.9-dimethyI-4,5- bis(diphenylphosphino)xanthene (1.5 mol%) and cesium carbonate (L29 mmol) in dioxane (2 mL) was heated in a microwave at 1500C for 20 minutes, cooled, filtered through diatomaceous earth (Celite) and concentrated.. The concentrate was purified by HPLC on a C18 column with acetonitrile/water/0.1% trifluoroacetic acid, 1H NMR (DMSOd6) delta 9 35 (br s, IH), 8.15 (s, IH), 6.45 (s, 2H), 5,5 (s, 2H), 3.73 (s, 6H), 3.70 (s, 3H).

With the rapid development of chemical substances, we look forward to future research findings about 94741-69-2.

Reference:
Patent; ABBOTT LABORATORIES; WO2007/140233; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia