Category: 947533-45-1

Adding a certain compound to certain chemical reactions, such as: 947533-45-1, 2-bromo-5-fluoropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 947533-45-1, blongs to pyrimidines compound. Recommanded Product: 947533-45-1

A mixture of 2-bromo-5-fluoropyrimidine (6.0 g, 33.9 mmol), Cul (646 mg, 3.4 mmol) and Pd(PPh3)4 (1.96 g, 1.7 mmol) in anhydrous DMA (100 mL) under a nitrogen atmosphere was treated with 2334-A (34.0 mL). The resulting mixture was stirred at 60 C for 48 h under a nitrogen atmosphere. The mixture was then diluted with water (400 mL) and extracted with EtOAc (200 mL x 3). The combined organic layers were washed with brine (200 mL x 3), dried over anhydrous Na2S04 and then concentrated in vacuo. The residue was purified by column chromatography on silica gel (PE : EtOAc = 20 :1 to 10 : 1) to give 2334-B (6.3 g, 70%) as a yellow solid. MS 212.1 [M – 55]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,947533-45-1, 2-bromo-5-fluoropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; RODIN THERAPEUTICS, INC.; FULLER, Nathan, Oliver; LOWE, John, A., III; (0 pag.)WO2020/14602; (2020); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 947533-45-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 947533-45-1, name is 2-bromo-5-fluoropyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

Step 2: Intermediate 4033A (100 mg, 0.180 mmol), 2-bromo-5-fluoropyrimidine (Frontier) (48 mg, 0.27 mmol, 1 .5 eq), potassium carbonate (87 mg, 0.63 mmol, 3.5 eq) and bis(tri-t- butylphosphine)palladium (0) (18 mg, 0.036 mmol, 0.20 eq) are charged in a microwave vial and DMF (1 .5 ml.) and water (0.50 ml.) are added. The vial is purged with argon, sealed and warmed in a microwave oven at 125 C for 10 min. The reaction mixture is filtered and purified by preparative HPLC to provide compound 4033 (tR: 1 .92, (M+H)+: 539.3/541 .3).

According to the analysis of related databases, 947533-45-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; FADER, Lee; LEPAGE, Olivier; BAILEY, Murray; BEAULIEU, Pierre Louis; BILODEAU, Francois; CARSON, Rebekah; GIROUX, Andre; GODBOUT, Cedrickx; MOREAU, Benoit; NAUD, Julie; PARISIEN, Mathieu; POIRIER, Martin; POIRIER, Maude; SURPRENANT, Simon; THIBEAULT, Carl; WO2013/152063; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 947533-45-1, 2-bromo-5-fluoropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 947533-45-1, blongs to pyrimidines compound. COA of Formula: C4H2BrFN2

A solution of NiCl2(glyme) (0.084 g, 0.384 mmol), 4-ie/7-butyl-2-(4-ie/7-butyl-2-pyridyl)pyridine, and Ir{dF(CF3)ppy}2(dtbpy)PF6(0.086 g, 0.077 mmol) in DME (80 mL) was sparged with N2for 15 min. The nickel solution was added to a mixture of //77-butyl 3- (bromomethyl)pyrrolidine-l-carboxylate (2.03 g, 7.68 mmol), 2-bromo-5-fluoro-pyrimidine (1.70 g, 9.61 mmol), tris(trimethylsilyl) silane (2.87 g, 11.5 mmol, 3.54 mL), and lithium hydroxide (0.736 mg, 30.7 mmol). After the mixture was sparged with N2(15 min), the reaction was irradiated with blue LEDs (48 watts 450 hv) overnight at 40 C. Celite was added to the reaction, and the mixture was filtered and concentrated in vacuo. The residue was purified over Si02(0-100% EtOAc:heptane) to afford the title compound (0.760 g). LCMS (ESI): [M – i-Bu] 226. 1HNMR: (500 MHz, CDCl3) d 8.39 (br d, 7=9.46 Hz, 2 H), 3.30 – 3.46 (m, 2 H), 3.10 – 3.21 (m, 1 H), 2.85 – 2.96 (m, 3 H), 2.54 – 2.66 (m, 1 H), 1.80 – 1.91 (m, 1 H), 1.42 – 1.57 (m, 1 H), 1.27 – 1.35 (m, 9 H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,947533-45-1, its application will become more common.

Reference:
Patent; BIOGEN MA INC.; GENUNG, Nathan; GUCKIAN, Kevin, M.; VESSELS, Jeffrey; ZHANG, Lei; GIANATASSIO, Ryan; LIN, Eaward Yin, Shiang; XIN, Zhili; (136 pag.)WO2019/178191; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 947533-45-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.947533-45-1, name is 2-bromo-5-fluoropyrimidine, molecular formula is C4H2BrFN2, molecular weight is 176.97, as common compound, the synthetic route is as follows.

In a 40 mL vial, chloro(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl- l,l ‘-biphenyl)[2-(2-aminoethyl)phenyl)]palladium(II) (0.025 g, 0.031 mmol), tert-butyl 3-((6-methoxy-2-(methylthio)-5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2- yl)pyrimidin-4-yl)arnino)piperidine-l-carboxylate (0.15 g, 0.312 mmol), 2-bromo-5- fluoropyrimidine (0.083 g, 0.468 mmol) and CuCl (0.031 g, 0.312 mmol) were combined, then purged with argon. Then degassed DMF (3 mL) followed by CS2CO3 (0.407 g, 1.249 mmol) were added to the vial. The reaction was then heated at 100 C for 18 h. The mixture was cooled, diluted with ethyl acetate, washed with water, dried (Na2SC>4), filtered and the solvent was evaporated under reduced pressure. The material was purified by column chromatography on silica gel (0-100% EtOAc in hexanes) to afford the desired product. MS (m z) = 451 (M+H).

The chemical industry reduces the impact on the environment during synthesis 947533-45-1, I believe this compound will play a more active role in future production and life.

Reference:
Patent; MERCK SHARP & DOHME CORP.; SEGANISH, W. Michael; BRUMFIELD, Stephanie Nicole; LIM, Jongwon; MATASI, Julius, J.; MCELROY, William, T.; TULSHIAN, Dean, B.; LAVEY, Brian, J.; ALTMAN, Michael, D.; GIBEAU, Craig, R.; LAMPE, John William; METHOT, Joey; ZHU, Liang; WO2013/66729; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 947533-45-1, 2-bromo-5-fluoropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 947533-45-1, blongs to pyrimidines compound. COA of Formula: C4H2BrFN2

A solution of NiCl2(glyme) (0.084 g, 0.384 mmol), 4-ie/7-butyl-2-(4-ie/7-butyl-2-pyridyl)pyridine, and Ir{dF(CF3)ppy}2(dtbpy)PF6(0.086 g, 0.077 mmol) in DME (80 mL) was sparged with N2for 15 min. The nickel solution was added to a mixture of //77-butyl 3- (bromomethyl)pyrrolidine-l-carboxylate (2.03 g, 7.68 mmol), 2-bromo-5-fluoro-pyrimidine (1.70 g, 9.61 mmol), tris(trimethylsilyl) silane (2.87 g, 11.5 mmol, 3.54 mL), and lithium hydroxide (0.736 mg, 30.7 mmol). After the mixture was sparged with N2(15 min), the reaction was irradiated with blue LEDs (48 watts 450 hv) overnight at 40 C. Celite was added to the reaction, and the mixture was filtered and concentrated in vacuo. The residue was purified over Si02(0-100% EtOAc:heptane) to afford the title compound (0.760 g). LCMS (ESI): [M – i-Bu] 226. 1HNMR: (500 MHz, CDCl3) d 8.39 (br d, 7=9.46 Hz, 2 H), 3.30 – 3.46 (m, 2 H), 3.10 – 3.21 (m, 1 H), 2.85 – 2.96 (m, 3 H), 2.54 – 2.66 (m, 1 H), 1.80 – 1.91 (m, 1 H), 1.42 – 1.57 (m, 1 H), 1.27 – 1.35 (m, 9 H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,947533-45-1, its application will become more common.

Reference:
Patent; BIOGEN MA INC.; GENUNG, Nathan; GUCKIAN, Kevin, M.; VESSELS, Jeffrey; ZHANG, Lei; GIANATASSIO, Ryan; LIN, Eaward Yin, Shiang; XIN, Zhili; (136 pag.)WO2019/178191; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 947533-45-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.947533-45-1, name is 2-bromo-5-fluoropyrimidine, molecular formula is C4H2BrFN2, molecular weight is 176.97, as common compound, the synthetic route is as follows.

In a 40 mL vial, chloro(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl- l,l ‘-biphenyl)[2-(2-aminoethyl)phenyl)]palladium(II) (0.025 g, 0.031 mmol), tert-butyl 3-((6-methoxy-2-(methylthio)-5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2- yl)pyrimidin-4-yl)arnino)piperidine-l-carboxylate (0.15 g, 0.312 mmol), 2-bromo-5- fluoropyrimidine (0.083 g, 0.468 mmol) and CuCl (0.031 g, 0.312 mmol) were combined, then purged with argon. Then degassed DMF (3 mL) followed by CS2CO3 (0.407 g, 1.249 mmol) were added to the vial. The reaction was then heated at 100 C for 18 h. The mixture was cooled, diluted with ethyl acetate, washed with water, dried (Na2SC>4), filtered and the solvent was evaporated under reduced pressure. The material was purified by column chromatography on silica gel (0-100% EtOAc in hexanes) to afford the desired product. MS (m z) = 451 (M+H).

The chemical industry reduces the impact on the environment during synthesis 947533-45-1, I believe this compound will play a more active role in future production and life.

Reference:
Patent; MERCK SHARP & DOHME CORP.; SEGANISH, W. Michael; BRUMFIELD, Stephanie Nicole; LIM, Jongwon; MATASI, Julius, J.; MCELROY, William, T.; TULSHIAN, Dean, B.; LAVEY, Brian, J.; ALTMAN, Michael, D.; GIBEAU, Craig, R.; LAMPE, John William; METHOT, Joey; ZHU, Liang; WO2013/66729; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Chemistry is an experimental science, Name: 2-bromo-5-fluoropyrimidine, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 947533-45-1, Name is 2-bromo-5-fluoropyrimidine, molecular formula is C4H2BrFN2, belongs to pyrimidines compound. In a document, author is Plaza-Pedroche, Rodrigo.

Effect of protonation on the photophysical properties of 4-substituted and 4,7-disubstituted quinazoline push-pull chromophores

White-light emission from single molecular systems has attracted a great deal of attention due to their advantages over multicomponent emitters. Azaheterocyclic push-pull derivatives have been demonstrated to be white emitters by combining neutral and protonated forms in the appropriate ratio, although limited cases of white light emission have been reported from quinazoline derivatives. Herein, we describe a series of push-pull 4-substituted and 4,7-disubstituted quinazolines that show white photoluminescence both in solution and in the solid state. All of the materials were prepared by straightforward Suzuki-Miyaura cross-coupling reactions and the compounds exhibited remarkable emission solvatochromism. In some cases the presence of acid prompted the appearance of emission bands of complementary colors. Thus, multicolor photoluminescence, including white light, could be finely tuned by the controlled protonation of the electron-deficient quinazoline ring.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 947533-45-1. Name: 2-bromo-5-fluoropyrimidine.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 947533-45-1, Name is 2-bromo-5-fluoropyrimidine, molecular formula is C4H2BrFN2. In an article, author is Li, Yejin,once mentioned of 947533-45-1, Computed Properties of C4H2BrFN2.

Transformation kinetics and pathways of sulfamonomethoxine by UV/H2O2 in swine wastewater

Sulfamonomethoxine (SMM), as one of the most predominant antibiotics in animal wastewater, is pending for effective control to minimize its environmental risks. Transformation kinetics and pathways of SMM by UV/H2O2 in swine wastewater were systematically investigated in this study. Direct UV photolysis (as a dominant role) and center dot OH oxidation contributed to SMM degradation in UV/H2O2 system. The less effective reaction rate of SMM in real wastewater than synthetic wastewater (0.1-0.17 vs. -0.2 -1.5 min 1 , despite higher H2O2 dosage and extended reaction time) resulted mainly from the abundant presence of conventional contaminants (indicated by COD, a notable competitor of SMM) in real wastewater. SMM degradation benefited from higher H2O2 dosage and neutral and weak alkaline conditions. However, the effect of initial SMM concentration on SMM degradation in synthetic and real wastewater showed opposite trends, owning to the different probability of SMM molecules to interact with UV and H2O2 in different matrices. Carbonate had an inhibitory effect on SMM degradation by scavenging center dot OH and pH-variation induced effect, while nitrate promoted SMM degradation by generating more center dot OH. The removal efficiency of SMM in real wastewater reached 91% under the reaction conditions of H2O2 of 10 mM, reaction time of 60 min, and pH 6.7-6.9. SMM degradation pathway was proposed as hydroxylation of benzene and pyrimidine rings, and secondary amine, and the subsequent cleavage of S-N bond. (C) 2020 Elsevier Ltd. All rights reserved.

Interested yet? Keep reading other articles of 947533-45-1, you can contact me at any time and look forward to more communication. Computed Properties of C4H2BrFN2.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Related Products of 947533-45-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 947533-45-1, Name is 2-bromo-5-fluoropyrimidine, SMILES is FC1=CN=C(Br)N=C1, belongs to pyrimidines compound. In a article, author is Sivakrishna, Balija, introduce new discover of the category.

Design, synthesis and cytotoxic evaluation of truncated 3 ‘-deoxy-3 ‘, 3 ‘ difluororibofuranosyl pyrimidine nucleosides

Truncated 3′-deoxy- 3′, 3′ difluororibofuranosyl pyrimidine nucleoside derivatives were synthesized from D-ribose via beta-apioribo pyrimidine nucleoside intermediates 11a-c. The synthetic approach signifies that truncation at C3’ position of apioribose ring of 13a-c by oxidative cleavage of diols with Pb(OAc)(4) and followed by fluorination with DAST as key steps. Cytotoxic evaluation of synthesized truncated nucleoside derivatives 16a-c and 19a-c were tested against MCF7 and MDA-MB-231 breast cancer cell lines. However, only 19a was shown minimal growth suppression activity on MDA-MB-231 cancer cell lines.

Related Products of 947533-45-1, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 947533-45-1.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Electric Literature of 947533-45-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 947533-45-1, Name is 2-bromo-5-fluoropyrimidine, SMILES is FC1=CN=C(Br)N=C1, belongs to pyrimidines compound. In a article, author is Vyshtakalyuk, A. B., introduce new discover of the category.

Double Pyrimidine Derivatives: Synthesis and Primary Assessment of Hepatoprotective Properties In Vitro

Double derivatives of the drug Xymedon (1,2-dihydro-4,6-dimethyl-1-N-(hydroxyethyl)pyrimidone-2), hereafter referred to as pyrimidine (I), in which the pyrimidine (I) molecules are joined by an alkyl(xylylenyl)dionate bridge have been synthesized. Primary data on the hepatoprotective activity of five double pyrimidine (I) derivatives with different numbers of methylene groups and a meta-xylylene fragment in the ester bridge have been obtained on normal human hepatocytes of the Chang Liver cell line. The cytotoxicity and the cytoprotective properties of the new compounds against the background of exposure to d-galactosamine at a concentration of 150 mmol/L have been determined, their effect on the cell cycle compared with that of the initial pyrimidine (I) has been studied, and the dependence of the biological properties of the derivatives on their structure has been established.

Electric Literature of 947533-45-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 947533-45-1 is helpful to your research.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia