Category: 947533-45-1

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Recommanded Product: 947533-45-1, 947533-45-1, Name is 2-bromo-5-fluoropyrimidine, molecular formula is C4H2BrFN2, belongs to pyrimidines compound. In a document, author is Abeykoon, Jithma P., introduce the new discover.

Salicylates enhance CRM1 inhibitor antitumor activity by induction of S-phase arrest and impairment of DNA-damage repair

Chromosome region maintenance protein 1 (CRM1) mediates protein export from the nucleus and is a new target for anticancer therapeutics. Broader application of KPT-330 (selinexor), a first-in-class CRM1 inhibitor recently approved for relapsed multiple myeloma and diffuse large B-cell lymphoma, have been limited by substantial toxicity. We discovered that salicylates markedly enhance the antitumor activity of CRM1 inhibitors by extending the mechanisms of action beyond CRM1 inhibition. Using salicylates in combination enables targeting of a range of blood cancers with a much lower dose of selinexor, thereby potentially mitigating prohibitive clinical adverse effects. Choline salicylate (CS) with low-dose KPT-330 (K+CS) had potent, broad activity across high-risk hematological malignancies and solid-organ cancers ex vivo and in vivo. The K+CS combination was not toxic to nonmalignant cells as compared with malignant cells and was safe without inducing toxicity to normal organs in mice. Mechanistically, compared with KPT-330 alone, K+CS suppresses the expression of CRM1, Rad51, and thymidylate synthase proteins, leading to more efficient inhibition of CRM1-mediated nuclear export, impairment of DNA-damage repair, reduced pyrimidine synthesis, cell-cycle arrest in S-phase, and cell apoptosis. Moreover, the addition of poly (ADP-ribose) polymerase inhibitors further potentiates the K+CS antitumor effect. K+CS represents a new class of therapy for multiple types of blood cancers and will stimulate future investigations to exploit DNA-damage repair and nucleocytoplasmic transport for cancer therapy in general.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 947533-45-1. Recommanded Product: 947533-45-1.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.947533-45-1, Name is 2-bromo-5-fluoropyrimidine, SMILES is FC1=CN=C(Br)N=C1, belongs to pyrimidines compound. In a document, author is Ari, Hatice, introduce the new discover, COA of Formula: C4H2BrFN2.

Monomeric or dimeric? A theoretical and vibrational spectroscopic approach to the structural stability of 5-(4-metoxy benzoyl)-6-(4-metoxyphenyl)-3-methyl-2-thioxo-2,3-dihydropyrimidine-4(1H)-on

The structural and the spectral characteristics of a pyrimidine derivative, 5-(4-metoxybenzoyl)-6-(4-metoxyphenyl)-3-methyl-2-thioxo-2,3-dihydropyrimidine-4(1H)-on (BPOP) was studied using density functional theory methods (DFT/B3LYP) employing 6-31G(d), 6-31G(d,p), 6-311G(d) and 6-311G(d,p) basis sets. Two BPOP molecules form a dimeric structure linked over two mutual N-H center dot center dot center dot S=C hydrogen bonds on each of the pyrimidine rings. The quantum chemical calculations of the optimized molecular structures, the energies and IR & Raman spectra of the monomeric and the dimeric forms of BPOP have been performed. The HOMO-LUMO and the molecular electrostatic potential surface (MEP) have also been plotted. The thermodynamic functions including enthalpy, entropy and heat capacity values and Mulliken charges of both structures have been calculated. The detailed assignments of vibrational modes have been made on the basis of potential energy distribution (PED). More accurate new scaling factors were obtained for the four basis sets. It was concluded that the experimental wavenumbers are in better agreement with the results of the dimeric structures calculated by all the methods. B3LYP/6-311G(d) method regenerated the best calculated values among the others. (C) 2020 Elsevier B.V. All rights reserved.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 947533-45-1 is helpful to your research. COA of Formula: C4H2BrFN2.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 947533-45-1, Name is 2-bromo-5-fluoropyrimidine, molecular formula is , belongs to pyrimidines compound. In a document, author is Rupp, Mira T., Safety of 2-bromo-5-fluoropyrimidine.

Substituted 2,4-Di(pyridin-2-yl)pyrimidine-Based Ruthenium Photosensitizers for Hydrogen Photoevolution under Red Light

The photocatalytic reduction of water to form hydrogen gas (H-2) is a promising approach to collect, convert, and store solar energy. Typically, ruthenium tris(bipyridine) and its many derivatives are used as photosensitizers (PSs) in a variety of photocatalytic conditions. The bis(terpyridine) analogues, however, have only recently gained attention for this application because of their poor photophysical properties. Yet, by the introduction of electron-donating or -withdrawing groups on the terpyridine ligands, the photophysical and electrochemical properties can be considerably improved. In this study, we report a series of nonsymmetric 2,6-di(pyridin-2-yl)pyrimidine ligands with peripheral pyridine substituents in different positions and their corresponding ruthenium(II) complexes. The presence of the pyrimidine ring stabilizes the lowest unoccupied molecular orbital, leading to a red-shifted emission and prolonged excited-state lifetimes as well as higher luminescence quantum yields compared to analogous terpyridine complexes. Furthermore, all complexes are easier to reduce than the previously reported bis(terpyridine) complexes used as PSs. Interestingly, the pyridine substituent in the 4-pyrimidine position has a greater impact on both the photophysical and electrochemical properties. This correlation between the substitution pattern and properties of the complexes is further investigated by using time-dependent density functional theory. In hydrogen evolution experiments under blue- and red-light irradiation, all investigated complexes exhibit much higher activity compared to the previously reported ruthenium(II) bis(terpyridine) complexes, but none of the complexes are as stable as the literature compounds, presumably because of an additional decomposition pathway of the reduced PS competing with electron transfer from the reduced PS to the catalyst.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 947533-45-1, in my other articles. Safety of 2-bromo-5-fluoropyrimidine.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 947533-45-1, Name is 2-bromo-5-fluoropyrimidine, molecular formula is C4H2BrFN2. In an article, author is Ibrahim, Tarek S.,once mentioned of 947533-45-1, Formula: C4H2BrFN2.

Design and synthesis of novel pyrazolo[3,4-d]pyrimidin-4-one bearing quinoline scaffold as potent dual PDE5 inhibitors and apoptotic inducers for cancer therapy

PDE5 targeting represents a new and promising strategy for apoptosis induction and inhibition of tumor cell growth due to its over-expression in diverse types of human carcinomas. Accordingly, we report the synthesis of series of pyrazolo[3,4-d]pyrimidin-4-one carrying quinoline moiety (11a-r) with potential dual PDE5 inhibition and apoptotic induction for cancer treatment. These hybrids were structurally elucidated and characterized with variant spectroscopic techniques as H-1 NMR, C-13 NMR and elemental analysis. The assessment of their anticancer activities has been declared. All the rationalized compounds 11a-r have been selected for their cytotoxic activity screening by NCI against 60 cell lines. Compounds 11a, 11b, 11j and 11k were the most active hybrids. Among all, compound 11j was further selected for five dose tesing and it displayed outstanding activity with strong antitumor activity against the nine tumor subpanels tested with selectivity ratios ranging from 0.019 to 8.3 at the GI(50) level. Further, the most active targets 11a, b, j and k were screened for their PDE5 inhibitory activity, compound 11j (with IC50 1.57 nM) exhibited the most potent PDE5 inhibitory activity. Moreover, compound 11j is also showed moderate EGFR inhibition with IC50 of 5.827 +/- 0.46 mu M, but significantly inhibited the Wnt/beta-catenin pathway with IC(50)1286.96 +/- 12.37 ng/mL. In addition, compound 11j induced the intrinsic apoptotic mitochondrial pathway in HepG2 cells as evidenced by the lower expression levels of the anti-apoptotic Bcl-2 protein, and the higher expression of the pro-apoptotic protein Bax, p53, cytochrome c and the up-regulated active caspase-9 and caspase-3 levels. All results confirmed by western blotting assay. Compound 11j exhibit pre G1 apoptosis and cell cycle arrest at G2/M phase. In conclusion, hybridization of quinoline moiety with the privileged pyrazolo[3,4-d]pyrimidinon-4-one structure resulted in highly potent anticancer agent, 11j, which deserves more study, in particular, in vivo and clinical investiagtions, and it is expected that these results would be applied for more drug discovery process.

Interested yet? Keep reading other articles of 947533-45-1, you can contact me at any time and look forward to more communication. Formula: C4H2BrFN2.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

In an article, author is Serevicius, Tomas, once mentioned the application of 947533-45-1, Category: pyrimidines, Name is 2-bromo-5-fluoropyrimidine, molecular formula is C4H2BrFN2, molecular weight is 176.97, MDL number is MFCD09835164, category is pyrimidines. Now introduce a scientific discovery about this category.

Single-exponential solid-state delayed fluorescence decay in TADF compounds with minimized conformational disorder

Thermally activated delayed fluorescence (TADF) compounds with rapid triplet upconversion in solutions frequently yield drastically lowered upconversion rates in solid hosts due to the conformational disorder, resulting in prolonged multiexponential TADF decay profiles. The dispersion of singlet-triplet gaps was shown to be the nature of this unwanted effect, minimized in compounds with more sterically confined molecular structure, though the observation of low solid-state disorder still is scarce. Therefore, here we present the unambiguous realization of rapid single-exponential solid-state TADF decay in the optimized acridine-pyrimidine TADF compound ACRPyr. The compound was designed to have a rigid molecular structure with negligible conformational disorder along with small singlet-triplet energy gaps, leading to rapid solid-state TADF with a lifetime of about 1.76 mu s, a fluorescence quantum yield of about 0.67 and an exceptional rISC rate of 5.7 x 10(6) s(-1). Furthermore, the ACRPyr based sky-blue OLED device showed a peak EQE of 14.3% with minor roll-off.

If you are interested in 947533-45-1, you can contact me at any time and look forward to more communication. Category: pyrimidines.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Related Products of 947533-45-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 947533-45-1, name is 2-bromo-5-fluoropyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

3-Methyl-1 ,3-butanediol (180 mg is stirred in 5 mL of Nu,Nu-dimethylformamide at 0 C, sodium hydride (6 mg of a 60% mineral oil suspension) is added and the reaction mixture is stirred for 2 h, then it is added dropwise to a solution of 2-bromo-4-fluoro- pyrimidine (300 mg) in 5 mL of N,N- dimethylformamide and the reaction mixture stirred at 0 C for 2 h again. The solvent is removed and the residue is purified by flash chromatography (hexane/ethyl acetate 90:10?70:30) to g i ve th e t it l e compound. Yield: 20 mg.

According to the analysis of related databases, 947533-45-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ECKHARDT, Matthias; FRATTINI, Sara; HAMPRECHT, Dieter; HIMMELSBACH, Frank; LANGKOPF, Elke; LINGARD, Iain; PETERS, Stefan; WAGNER, Holger; WO2013/144098; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia