Category: 951884-36-9

Ham, Won Seok; Choi, Hoonchul; Zhang, Jianbo; Kim, Dongwook; Chang, Sukbok published an article on February 23 ,2022. The article was titled 《C2-Selective, Functional-Group-Divergent Amination of Pyrimidines by Enthalpy-Controlled Nucleophilic Functionalization》, and you may find the article in Journal of the American Chemical Society.Reference of 5-Bromo-4-ethylpyrimidine The information in the text is summarized as follows:

A synthetic platform for site-selective C-H functionalization that affords pyrimidinyl iminium salt intermediates, which then can be transformed into various amine products I (R = azanyl, 5-(trifluoromethyl)-1,2,3,4-tetrahydropyridin-1-yl, methylaminyl, etc.; R1 = H, Ph) in situ. was described. Mechanism-based reagent design allowed for the C2-selective amination of pyrimidines II, opening the new scope of site-selective heteroaryl C-H functionalization. This method is compatible with a broad range of pyrimidines II with sensitive functional groups, and can access complex aminopyrimidines I in high selectivity. The experimental part of the paper was very detailed, including the reaction process of 5-Bromo-4-ethylpyrimidine(cas: 951884-36-9Reference of 5-Bromo-4-ethylpyrimidine)

5-Bromo-4-ethylpyrimidine(cas: 951884-36-9) is a member of pyrimidine. Pyrimidine derivatives are an important class of N-heterocycles. They are well-known for their wide spectrum of promising biological activities such as antitumors, bactericidals, and fungicidal.Reference of 5-Bromo-4-ethylpyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The author of 《Benzylic Fluorination of Aza-Heterocycles Induced by Single-Electron Transfer to Selectfluor》 were Danahy, Kelley E.; Cooper, Julian C.; Van Humbeck, Jeffrey F.. And the article was published in Angewandte Chemie, International Edition in 2018. HPLC of Formula: 951884-36-9 The author mentioned the following in the article:

A selective and mild method for the benzylic fluorination of aromatic azaheterocycles with Selectfluor is described. These reactions take place by a previously unreported mechanism, in which electron transfer from the heterocyclic substrate to the electrophilic fluorinating agent Selectfluor eventually yields a benzylic radical, thus leading to the desired C-F bond formation. This mechanism enables high intra- and intermol. selectivity for aza-heterocycles over other benzylic components with similar C-H bond-dissociation energies. After reading the article, we found that the author used 5-Bromo-4-ethylpyrimidine(cas: 951884-36-9HPLC of Formula: 951884-36-9)

5-Bromo-4-ethylpyrimidine(cas: 951884-36-9) is a member of pyrimidine. Pyrimidine derivatives are an important class of N-heterocycles. They are well-known for their wide spectrum of promising biological activities such as antitumors, bactericidals, and fungicidal.HPLC of Formula: 951884-36-9

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Cooper, Julian C.; Luo, Chaosheng; Kameyama, Ryohei; Van Humbeck, Jeffrey F. published an article on January 31 ,2018. The article was titled 《Combined Iron/Hydroxytriazole Dual Catalytic System for Site Selective Oxidation Adjacent to Azaheterocycles》, and you may find the article in Journal of the American Chemical Society.Safety of 5-Bromo-4-ethylpyrimidine The information in the text is summarized as follows:

This report details a new method for site-selective methylene oxidation adjacent to azaheterocycles. A dual catalysis approach, utilizing both an iron Lewis acid and an organic hydroxylamine catalyst, proved highly effective. We demonstrate that this method provides complementary selectivity to other known catalytic approaches and represents an improvement over current heterocycle-selective reactions that rely on stoichiometric activation. After reading the article, we found that the author used 5-Bromo-4-ethylpyrimidine(cas: 951884-36-9Safety of 5-Bromo-4-ethylpyrimidine)

5-Bromo-4-ethylpyrimidine(cas: 951884-36-9) is a member of pyrimidine. Pyrimidine derivatives are an important class of N-heterocycles. They are well-known for their wide spectrum of promising biological activities such as antitumors, bactericidals, and fungicidal.Safety of 5-Bromo-4-ethylpyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《A Convenient Late-Stage Fluorination of Pyridylic C-H Bonds with N-Fluorobenzenesulfonimide》 was published in Angewandte Chemie, International Edition in 2016. These research results belong to Meanwell, Michael; Nodwell, Matthew B.; Martin, Rainer E.; Britton, Robert. Synthetic Route of C6H7BrN2 The article mentions the following:

Pyridine features prominently in pharmaceuticals and drug leads, and methods to selectively manipulate pyridine basicity or metabolic stability are highly sought after. A robust, metal-free direct fluorination of unactivated pyridylic C-H bonds was developed. This convenient reaction shows high functional-group tolerance and offers complimentary selectivity to existing C-H fluorination strategies. Importantly, this late-stage pyridylic C-H fluorination provides opportunities to rationally modulate the basicity, lipophilicity, and metabolic stability of alkylpyridine drugs. Thus, e.g., mixing 4-ethylpyridine with NFSI in MeCN afforded 4-(1-fluoroethyl)pyridine (87%). The results came from multiple reactions, including the reaction of 5-Bromo-4-ethylpyrimidine(cas: 951884-36-9Synthetic Route of C6H7BrN2)

5-Bromo-4-ethylpyrimidine(cas: 951884-36-9) is a member of pyrimidine. Pyrimidine derivatives are an important class of N-heterocycles. They are well-known for their wide spectrum of promising biological activities such as antitumors, bactericidals, and fungicidal.Synthetic Route of C6H7BrN2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia